Tate Mitchell posted this to co-cure today.
[if: Thank goodness real science is continuing!]
'Abnormalities in pH handling by peripheral muscle and potential
regulation by the autonomic nervous system in chronic fatigue syndrome'
Jones, D. E. J.1; Hollingsworth, K. G.2; Taylor, R.2; Blamire, A. M.2;
Newton, J. L.
Journal of Internal Medicine, Volume 267, Number 4, April 2010 , pp. 394-401(8)
Affiliations: 1: From the Institute of Cellular Medicine 2: Newcastle
Magnetic Resonance Centre
Jones DEJ, Hollingsworth KG, Taylor R, Blamire AM, Newton JL (From the
Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre,
and Institute for Ageing and Health, Newcastle University, UK).
Abnormalities in pH handling by peripheral muscle and potential
regulation by the autonomic nervous system in chronic fatigue
syndrome. J Intern Med 2010; 267: 394-401.
http://www.ingentaconnect.com/content/bsc/jint/2010/00000267/00000004/art00006
Abstract:
Objectives. To examine muscle acid handling following exercise in
chronic fatigue syndrome (CFS/ME) and the relationship with autonomic
dysfunction.
Design. Observational study.
Setting. Regional fatigue service.
Subjects & interventions. Chronic fatigue syndrome (n = 16) and age
and sex matched normal controls (n = 8) underwent phosphorus magnetic
resonance spectroscopy (MRS) to evaluate pH handling during exercise.
Subjects performed plantar flexion at fixed 35% load maximum voluntary
contraction. Heart rate variability was performed during 10 min supine
rest using digital photophlethysmography as a measure of autonomic
function.
Results. Compared to normal controls, the CFS/ME group had significant
suppression of proton efflux both immediately postexercise (CFS: 1.1
0.5 mmol L−1 min−1 vs. normal: 3.6 1.5 mmol L−1 min−1, P < 0.001)
and maximally (CFS: 2.7 3.4 mmol L−1 min−1 vs. control: 3.8 1.6
mmol L−1 min−1, P < 0.05). Furthermore, the time taken to reach
maximum proton efflux was significantly prolonged in patients (CFS:
25.6 36.1 s vs. normal: 3.8 5.2 s, P < 0.05). In controls the rate
of maximum proton efflux showed a strong inverse correlation with
nadir muscle pH following exercise (r2 = 0.6; P < 0.01). In CFS
patients, in contrast, this significant normal relationship was lost
(r2 = 0.003; P = ns). In normal individuals, the maximum proton efflux
following exercise were closely correlated with total heart rate
variability (r2 = 0.7; P = 0.007) this relationship was lost in CFS/ME
patients (r2 < 0.001; P = ns).
Conclusion. Patients with CFS/ME have abnormalities in recovery of
intramuscular pH following standardised exercise degree of which is
related to autonomic dysfunction. This study identifies a novel
biological abnormality in patients with CFS/ME which is potentially
open to modification.
Keywords: autonomic dysfunction; chronic fatigue syndrome; magnetic
resonance spectroscopy; muscle bioenergetics
Document Type: Research article
DOI: 10.1111/j.1365-2796.2009.02160.x
Affiliations: 1: From the Institute of Cellular Medicine 2: Newcastle
Magnetic Resonance Centre
[if: Thank goodness real science is continuing!]
'Abnormalities in pH handling by peripheral muscle and potential
regulation by the autonomic nervous system in chronic fatigue syndrome'
Jones, D. E. J.1; Hollingsworth, K. G.2; Taylor, R.2; Blamire, A. M.2;
Newton, J. L.
Journal of Internal Medicine, Volume 267, Number 4, April 2010 , pp. 394-401(8)
Affiliations: 1: From the Institute of Cellular Medicine 2: Newcastle
Magnetic Resonance Centre
Jones DEJ, Hollingsworth KG, Taylor R, Blamire AM, Newton JL (From the
Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre,
and Institute for Ageing and Health, Newcastle University, UK).
Abnormalities in pH handling by peripheral muscle and potential
regulation by the autonomic nervous system in chronic fatigue
syndrome. J Intern Med 2010; 267: 394-401.
http://www.ingentaconnect.com/content/bsc/jint/2010/00000267/00000004/art00006
Abstract:
Objectives. To examine muscle acid handling following exercise in
chronic fatigue syndrome (CFS/ME) and the relationship with autonomic
dysfunction.
Design. Observational study.
Setting. Regional fatigue service.
Subjects & interventions. Chronic fatigue syndrome (n = 16) and age
and sex matched normal controls (n = 8) underwent phosphorus magnetic
resonance spectroscopy (MRS) to evaluate pH handling during exercise.
Subjects performed plantar flexion at fixed 35% load maximum voluntary
contraction. Heart rate variability was performed during 10 min supine
rest using digital photophlethysmography as a measure of autonomic
function.
Results. Compared to normal controls, the CFS/ME group had significant
suppression of proton efflux both immediately postexercise (CFS: 1.1
0.5 mmol L−1 min−1 vs. normal: 3.6 1.5 mmol L−1 min−1, P < 0.001)
and maximally (CFS: 2.7 3.4 mmol L−1 min−1 vs. control: 3.8 1.6
mmol L−1 min−1, P < 0.05). Furthermore, the time taken to reach
maximum proton efflux was significantly prolonged in patients (CFS:
25.6 36.1 s vs. normal: 3.8 5.2 s, P < 0.05). In controls the rate
of maximum proton efflux showed a strong inverse correlation with
nadir muscle pH following exercise (r2 = 0.6; P < 0.01). In CFS
patients, in contrast, this significant normal relationship was lost
(r2 = 0.003; P = ns). In normal individuals, the maximum proton efflux
following exercise were closely correlated with total heart rate
variability (r2 = 0.7; P = 0.007) this relationship was lost in CFS/ME
patients (r2 < 0.001; P = ns).
Conclusion. Patients with CFS/ME have abnormalities in recovery of
intramuscular pH following standardised exercise degree of which is
related to autonomic dysfunction. This study identifies a novel
biological abnormality in patients with CFS/ME which is potentially
open to modification.
Keywords: autonomic dysfunction; chronic fatigue syndrome; magnetic
resonance spectroscopy; muscle bioenergetics
Document Type: Research article
DOI: 10.1111/j.1365-2796.2009.02160.x
Affiliations: 1: From the Institute of Cellular Medicine 2: Newcastle
Magnetic Resonance Centre