Hi!
A few days ago I got my 23andme reports back.
I am especially interested in the enzyme that is converting glutamine/glutamate into GABA.
The only drugs I ever responded to in a positive way (no more anxiety, less pain, no insomnia) were gaba-ergic drugs like antiepileptics and benzodiazepines. I became very senstive to every medication, so that's no option any longer beside the fact that I don't want to be dependend on benzos. I also do NOT respond positively to the GABA supplement (capsules).
So my doctor suggested to give l-glutamine a try but his concern is about stimulating the NMDA-receptors rather than converting it into GABA via the GAD-enzyme.
I have 9 versions of the GAD1 enzyme, unfortunately promethase is not telling me weather it's the normal or the slow version of the enzyme. I have 3 homozygous versions, two of it rare and hetero versions.
So it's
rs2241165(G;G) (Frequency 2,7%)
1 rs3749034(T;T) (2,7%)
2 rs3828275(G;G)
3 rs2058725(A;G)
4 rs3791851(A;G)
5 rs769407(C;G)
6 rs3791878(C;C)
7 rs12185692(C;C)
8 rs3791850(A;G)
Most oft them are tagged with anxiety disorder & depression.
Does anyone know about it?
I am also homoc. for MAO-A and hetero for COMT, so I guess that could be the reason why normal antidepressants did noting for me instead (some of them actually worsened my condition)
Thank you!
A few days ago I got my 23andme reports back.
I am especially interested in the enzyme that is converting glutamine/glutamate into GABA.
The only drugs I ever responded to in a positive way (no more anxiety, less pain, no insomnia) were gaba-ergic drugs like antiepileptics and benzodiazepines. I became very senstive to every medication, so that's no option any longer beside the fact that I don't want to be dependend on benzos. I also do NOT respond positively to the GABA supplement (capsules).
So my doctor suggested to give l-glutamine a try but his concern is about stimulating the NMDA-receptors rather than converting it into GABA via the GAD-enzyme.
I have 9 versions of the GAD1 enzyme, unfortunately promethase is not telling me weather it's the normal or the slow version of the enzyme. I have 3 homozygous versions, two of it rare and hetero versions.
So it's
rs2241165(G;G) (Frequency 2,7%)
1 rs3749034(T;T) (2,7%)
2 rs3828275(G;G)
3 rs2058725(A;G)
4 rs3791851(A;G)
5 rs769407(C;G)
6 rs3791878(C;C)
7 rs12185692(C;C)
8 rs3791850(A;G)
Most oft them are tagged with anxiety disorder & depression.
Does anyone know about it?
I am also homoc. for MAO-A and hetero for COMT, so I guess that could be the reason why normal antidepressants did noting for me instead (some of them actually worsened my condition)
Thank you!