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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Interested but scared of the rep of chineses suppliers..can you say anything more to reassure me?
@aturtles, what dosage are you able to use with your nasal spray? How often/day do you "snort" to get your daily dose? Do you end up with a bright red nose??
I'm very interested in this but unsure of delivery methods. I'm not comfortable with compounding my own injectable B12.
Also, what about adenosylB12? Greg from B12oils.com feels pretty strongly most people should have a mix of methyl and adenosyl, roughly 1:3.
I'm taking about 1.5mg/day mB12 and 4.5mg/day adenosylB12 (injected equivalent) with the oils. I would like to experiment with higher doses but it's already running me about $2/day.
Thanks @aturtles, that sounds easy enough. I'll jump onto your group buy.
@Freddd, I know you're not a fan of constant AdoB12. I haven't tested it enough to be certain, but I can say with certainty that methyl-only oil didn't work well for me, and Ado/Methyl mixture (3:1) has worked well for over a year. (Though it may be losing some effectiveness in the last few months.) I have some methyl-only oil and I plan to test your "AdoB12 once a week" sometime soon, probably using 10mg Source Naturals Dibencozide = 8.6mg AdoB12. I don't know how much I should use once a week but I doubt I'd need 50mg like you use.
I realized there was another variable besides Methyl vs. Ado/Methyl: dosage. I was using 3x/day. The Ado/Methyl has the injected equivalent of 0.5mg methyl & 1.5mg ado, so I was getting 1.5mg + 4.5mg = 6.0mg total, per day. The methyl-only oil has the equivalent of 0.6mg, so 1.8mg total per day. Maybe that just wasn't enough, in the absence of the adenosyl. I don't know how "interchangeable" methyl and adenosyl are, but I wonder if "lots of methyl" (with weekly/whatever adenosyl) might have worked as well as the daily 6mg dose of methyl/adenosyl?I haven't tested it enough to be certain, but I can say with certainty that methyl-only oil didn't work well for me, and Ado/Methyl mixture (3:1) has worked well for over a year.
Thanks @Freddd, I'll keep that in mind when I start boosting my methyl. So even if the sublingual is on your mucosa for an hour or more (e.g. between lip and gum) you still saw only 15-20% absorption?To figure 50mg sublingual I assumed 15%-20% absorption to duplicate 7.5 mg to 10 mg injection.
I realized there was another variable besides Methyl vs. Ado/Methyl: dosage. I was using 3x/day. The Ado/Methyl has the injected equivalent of 0.5mg methyl & 1.5mg ado, so I was getting 1.5mg + 4.5mg = 6.0mg total, per day. The methyl-only oil has the equivalent of 0.6mg, so 1.8mg total per day. Maybe that just wasn't enough, in the absence of the adenosyl. I don't know how "interchangeable" methyl and adenosyl are, but I wonder if "lots of methyl" (with weekly/whatever adenosyl) might have worked as well as the daily 6mg dose of methyl/adenosyl?
I will find out when the group buy comes through!
Thanks @Freddd, I'll keep that in mind when I start boosting my methyl. So even if the sublingual is on your mucosa for an hour or more (e.g. between lip and gum) you still saw only 15-20% absorption?
Sure would be nice if there was a more effective delivery mechanism. B12oils.com has an adenosyl-only oil, with presumably the same high 80% absorption rate that they've seen for the methyl. I don't know the dosage in a squirt, but if it's 1.5mg like the ado/me oil, it would take 5-7 squirts to get the 7.5-10mg injected equivalent you're looking for. Effective but pricey.
@skwag, your Chinese supplier doesn't sell pure adenosyl crystals, do they? I can't find any on alibaba. It would be nice to be able to mix up some adenosyl spray.
Wait, was that last part still talking about AdoCbl? That seems to contradict your "once a week works well for AdoCbl" statements?? It sounds like you switched to describing your protocol for MeCbl saturation.I did a small amount of work with liquid AdoCbl.... I found the same CNS threshold, 7.5mg, as MeCbl. ... The key was to keep 1.25mg per hour getting absorbed into the serum maintaining an approximate level of perhaps 200,000 pg/ml 24/7 which made for a steep diffusion gradiant that made it through the BBB and kept the remyelination going around the clock. Stop and start every day did no good. So the effective doses for most people were 4x7.5, 3x10mg and for some, 2x15mg.
@garyfritz;
I can't agree in ANY way with the 1:3 MeCbl:AdoCbl at the same time.
I have run series of these trials. AdoCbl can cause cell level methyltrap just as zero star MeCbl, CyCbl and HyCbl can. In the brain it increases "irritability", can cause depression and other mood and character changes in relationship to relative MeCbl level.
So if a person is having ANY mysterious folate deficiency symptoms, mostly noticeable in the epithelial and neurological tissues, and the others I have no idea about as those require much longer tests to see the changes, and is doing everything else right, AdoCbl all day every day would be a favorite for changing on a trial basis. It nreeds to be done to see what else is missing, like trace minerals. I trialed continuous ratios all day, 1:3, 1:2, 1:1, 2:1, 3:1 and once a week to once a month at doses from 10 to 50mg (AdoCbl mass, not adjusted for CyCbl mass).