why is me/cfs incidence higher after puberty (in women only?)

[xena]

hi everyone, i'm curious about why we think this is....

i believe KDM had some kind of explanation for it. i personally had biotoxin expsure from 11-13 but only seem to have gone into full scale me/cfs at puberty

 

[Kati]

I do not have references to provide you but there are 2 known peaks of increased incidence at least in women, the first one is during puberty, as teen and the second peak is in the middle age, 35-50.

This would suggest the influence of hormones in disease process but at the moment, more research is needed.

 

[Hip]

There is a study on this:

Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008–2012

For ME/CFS onset, the study found there were two peaks in the figures: a first peak in the age group 10 to 19 years, and a second peak in the age group 30 to 39 years.

The first peak of people coming down with ME/CFS from 10 to 19 years might involve Epstein-Barr virus as a trigger, because EBV is picked up in the teenage years.

 

[xena]

thanks @Hip @Kati

leaving more refs for myself:

http://phoenixrising.me/research-2/...-fatigue-syndrome-higher-in-women-than-in-men

http://www.cortjohnson.org/blog/201...ndrome-gender-connection-women-men-get-mecfs/

and i should rewatch KDM's videos... https://www.youtube.com/user/WetenschapvMEcvsVer/videos?shelf_id=0&view=0&sort=dd this series i think

 

[WillowJ]

Here's a post by @Jonathan Edwards which has an interesting discussion about onset.
http://forums.phoenixrising.me/index.php?threads/do-mes-cause-cfs.31930/page-17#post-498268

I thought I recalled a discussion by him about the gender prevalence, too, which I liked because it nowhere mentioned estrogen. But I'm afraid I don't recall the other details. It may have been in the same thread, but I couldn't find it by searching.

 

[pattismith]

[/QUOTE]
Thank you for this article Xena

thanks @Hip @Kati

leaving more refs for myself:

http://phoenixrising.me/research-2/...-fatigue-syndrome-higher-in-women-than-in-men

Interesting as the article makes a possible connection between ME in women and genetic polymorphism in the Cytochrome P450,

with impaired CYP3A and CYP1A2 activity (slow metabolizers), and/or increase CYP1B1 activity (fast metabolizers).

it would be interesting to know the genetic status of members for these CYP and see if it matches!

I do myself suspect to carry slow CYP, as I had several side effects with drugs,

salicylic acid
coffee
ephedrine
Amitriptyline

Coffee is metabolized by CYP1A2 so I may be concerned by an inactivated variant on this gene.
Salicylic acid is metabolized by CYP2C9
Amitriptyline by CYP3A4, so again I may have impaired CYP3A4,

It would be consistent with the hypothesis in the article...

Maybe someone here knows about ones genetic polymorphism for CYP3A4 and CYP1A2, to see if the hypothesis correlates with us?

There is a study on this:

Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008–2012

For ME/CFS onset, the study found there were two peaks in the figures: a first peak in the age group 10 to 19 years, and a second peak in the age group 30 to 39 years.

The first peak of people coming down with ME/CFS from 10 to 19 years might involve Epstein-Barr virus as a trigger, because EBV is picked up in the teenage years.

interesting as my first symptoms started around 13 years old and progressed slowly, and I had a big "crash at 35 years old"...