• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Solute Transporters and Health

ppodhajski

Senior Member
Messages
243
Location
Chapel Hill, NC
I have been having an interesting time looking at the Solute Transporters (SLC) of all the 15 gene samples I have with people of varying levels of disease. I have noticed a trend, that the number of SLC gene SNPs that a persons has with a frequency of under 20% is correlated with health. Those with under 20 have very few health complaints. Those with 40 or more start showing signs of debilitating health. The sickest person I have genes for, a 26 year old female on disability for several degenerative diseases and mental health issues, has over 80 SLC SNPs under 20%!

It is acknowledged they play a role in health
http://www.ncbi.nlm.nih.gov/pubmed/23506860
"The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease."

If you have you promethease report you can count these simply by searching for SLC, set the sort function to "Frequency", and increase the "Allow" number to 80. Then just scroll through and count.

I made a video of how to do this here:

If you want to check what your SLC gene SNPs might signal you can check what the the specific gene does here:
http://www.bioparadigms.org/slc/intro.htm
or
http://www.genenames.org/genefamilies/SLC

Here are my SNPs that are under 20%

SLC28A2 Sodium/nucleoside
SLC6A4 Serotonin
SLC6A1 GABA
SLC5A1 Sodium/Glucose
SLC23A2 Sodium/Ascorbate
SLC40A1 Iron
SLC2A9 Urate Fructose
SLC35F1 Drug Metabolite
SLC45A3 Transmembrane Lipid?
SLC4A1 Chloride/Bicarbonate
SLC25A27 Proton Leak (Thermoregulation)
SLC2A1 Glucose
SLCO1B1 organic anions
SLC23A2 Sodium/Ascorbate
SLC6A3 Dopamine
SLC2A2 Glucose
SLC16A10 Aromatic Acids
SLC1A2 Glutamate Aspratate
SLC8A1 Calcium
SLC6A2 Norepinepherine
SLC6A4 Serotonin
SLC45A2 May transport substances required for melanin biosynthesis
SLC6A4 Serotonin
SLC18A1 Biogenic Amines into Vascules
SLC6A4 Serotonin
SLC22A18 ?
SLC36A3 Proton-coupled amino acid transporter
SLC1A2 Glutamate Aspratate
SLC45A2 May transport substances required for melanin biosynthesis
SLC34A1 Phosphate
SLC16A6 Monocarboxylate Transporter
SLCO1B1 organic anions
SLC28A1 Sodium Nucleotide
SLC6A2 Norepinepherine
SLC9A9 May act in electroneutral exchange of protons for Na+ across membranes.
SLCO1B1 organic anions
SLC16A6 Monocarboxylate Transporter
SLC22A5 Carnitine
SLC18A2 Vesicluar Amine Transporter
SLC4A5 Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport,
SLC2A2 Glucose
SLC2A2 Glucose
SLC25A43 Transmembrane Lipid?
 
Last edited:

ppodhajski

Senior Member
Messages
243
Location
Chapel Hill, NC
That is a fascinating one to me. it seems it is on or off and I think it has something to do with awareness of some sor. Now sure how to express it. I do not have that one.
 

skwag

Senior Member
Messages
222
37 under 20% here. A different 0% rs16923647 (T;T).

Interestingly, six of those are red ( bad ), and the rest are not set.
 
Last edited:

ppodhajski

Senior Member
Messages
243
Location
Chapel Hill, NC
37 under 20% here. A different 0% rs16923647 (T;T).

Interestingly, six of those are red ( bad ), and the rest are not set.

Welcome to the club. :( Wondering about your health history?

That is SLCO1A2, a bile acid transporter in the liver it seems. No idea what that means though.
 

mariovitali

Senior Member
Messages
1,214
Haha i have 43 under 20% Nice one! :thumbsup:

I too have rs557881 at 0% and also rs9469300 at 0%. I would like to compare MANY more results from CFS sufferers with MANY more results of non-CFS sufferers as well though ;)


Then i match "solute transporter" to my software :


*********Topic : solute transporter ***************
car.csv : 0.29 %
pxr.csv : 0.23 %
udpglcnac.csv : 0.19 %
hexosamine.csv : 0.09 %
choline_deficiency.csv : 0.08 %

l_carnitine.csv : 0.08 %
cholestasis.csv : 0.07 %
rxr.csv : 0.06 %
taurine.csv : 0.05 %
urea_cycle.csv : 0.03 %
monosodium_glutamate.csv : 0.03 %
nafld.csv : 0.03 %
hepatocytes.csv : 0.02 %
lipoic_acid.csv : 0.02 %
3betahsd.csv : 0.02 %
l_tryptophan.csv : 0.02 %
beta-alanine.csv : 0.02 %
steatohepatitis.csv : 0.02 %
n-acetylglucosamine.csv : 0.02 %
glycoproteins.csv : 0.02 %
hydroxysteroid_dehydrogenase.csv : 0.02 %
reduced_glutathione.csv : 0.02 %
udpgluc.csv : 0.02 %
pregnenolone.csv : 0.01 %
endothelial_nos.csv : 0.01 %
glycosylation.csv : 0.01 %
serotonin_levels.csv : 0.01 %
butyrate.csv : 0.01 %
calcium_homeostasis.csv : 0.01 %
er_stress.csv : 0.01 %
gaba_human.csv : 0.01 %
inositol.csv : 0.01 %
acetyl-coa.csv : 0.01 %
vitamin_d3.csv : 0.01 %
p450oxidoreductase.csv : 0.01 %
hepatotoxicity.csv : 0.01 %
histone_deacetylase.csv : 0.01 %
crohns_disease.csv : 0.01 %
glutamate.csv : 0.01 %
hsp70.csv : 0.01 %
gluten.csv : 0.00 %
l-dopa.csv : 0.00 %
l-arginine.csv : 0.00 %
ckd.csv : 0.00 %
norepinephrine.csv : 0.00 %
immune_response.csv : 0.00 %
phosphatidylcholine.csv : 0.00 %
heat_shock_protein.csv : 0.00 %
phospholipid_human.csv : 0.00 %
angiotensin_human.csv : 0.00 %
dopamine.csv : 0.00 %
thioredoxin_reductase.csv : 0.00 %
tudca.csv : 0.00 %
dolichol.csv : 0.00 %
insomnia.csv : 0.00 %
5-htp.csv : 0.00 %
adrenal_hyperplasia.csv : 0.00 %
insulin_resistance.csv : 0.00 %
omega3.csv : 0.00 %
mastocytosis.csv : 0.00 %
scfa.csv : 0.00 %
isotretinoin.csv : 0.00 %
p450scc.csv : 0.00 %
limbic_system.csv : 0.00 %
il_10.csv : 0.00 %
coenzymeq10.csv : 0.00 %
sirt1.csv : 0.00 %
ros.csv : 0.00 %
5mthf.csv : 0.00 %
panic_disorder.csv : 0.00 %
neuronal_nos.csv : 0.00 %
protease_inhibitor.csv : 0.00 %
adhd.csv : 0.00 %
microglia.csv : 0.00 %
iron_deficiency.csv : 0.00 %
dpagt1.csv : 0.00 %
stat1.csv : 0.00 %
pgc1.csv : 0.00 %
dht.csv : 0.00 %
advanced_glycation_end.csv : 0.00 %
hmgb1.csv : 0.00 %
phenylketonuria.csv : 0.00 %
irritable_bowel.csv : 0.00 %
sshl.csv : 0.00 %
5alphareductase.csv : 0.00 %
l_tyrosine.csv : 0.00 %
ire1.csv : 0.00 %
gtp_cyclohydrolase.csv : 0.00 %
ebv.csv : 0.00 %
misfolded_proteins.csv : 0.00 %
upr.csv : 0.00 %
inflammatory_response.csv : 0.00 %
nlinkedglycosylation.csv : 0.00 %
riboflavin.csv : 0.00 %
mast_cell_activation.csv : 0.00 %
hmgcoa.csv : 0.00 %
insp3.csv : 0.00 %
gpr78.csv : 0.00 %
xbp1.csv : 0.00 %
autism.csv : 0.00 %
resveratrol.csv : 0.00 %
orthostatic_intolerance.csv : 0.00 %
probiotics.csv : 0.00 %
cerebrovascular_amyloidosis.csv : 0.00 %
social_anxiety.csv : 0.00 %
systemic_amyloidosis.csv : 0.00 %
oxalates.csv : 0.00 %
microbiome_humans.csv : 0.00 %
caspase_human.csv : 0.00 %
ngf.csv : 0.00 %
inducible_nos.csv : 0.00 %
adrenal_insufficiency.csv : 0.00 %
mcp-1.csv : 0.00 %
perk.csv : 0.00 %
peroxynitrite.csv : 0.00 %
finasteride.csv : 0.00 %
cfs.csv : 0.00 %
adrenergic_receptor.csv : 0.00 %
atf6.csv : 0.00 %
selenium_deficiency.csv : 0.00 %
glycerylphosphorylcholine.csv : 0.00 %
benfotiamine.csv : 0.00 %
vcam-1.csv : 0.00 %
cimetidine.csv : 0.00 %
anhedonia.csv : 0.00 %
tocotrienol.csv : 0.00 %
cyp3a4.csv : 0.00 %
human_proteinuria.csv : 0.00 %
cyp2d6.csv : 0.00 %
fmo3.csv : 0.00 %
dopamine_levels.csv : 0.00 %
baroreceptor.csv : 0.00 %
rar.csv : 0.00 %
o-glcnacylation.csv : 0.00 %
fads2.csv : 0.00 %
neurite_outgrowth.csv : 0.00 %
mitochondrial_dysfunction.csv : 0.00 %
sinusitis.csv : 0.00 %
p5p.csv : 0.00 %
pqq.csv : 0.00 %
cyp1a2.csv : 0.00 %
testosterone_production.csv : 0.00 %
freet3.csv : 0.00 %
uric_acid.csv : 0.00 %
mucuna.csv : 0.00 %
vitamin_b6.csv : 0.00 %
dysautonomia.csv : 0.00 %
cox-2.csv : 0.00 %
amyloid.csv : 0.00 %
fads1.csv : 0.00 %
nadh_human.csv : 0.00 %
ginkgo.csv : 0.00 %
caloric_restriction.csv : 0.00 %
allopregnanolone.csv : 0.00 %
tetrahydrobiopterin.csv : 0.00 %
mthfr.csv : 0.00 %
amyloidosis.csv : 0.00 %
human_semen.csv : 0.00 %
erad.csv : 0.00 %
vitamin_k2.csv : 0.00 %
curcumin.csv : 0.00 %
creatine_supplementation.csv : 0.00 %
steroidogenesis_human.csv : 0.00 %
cyp1b1.csv : 0.00 %
oxidative_stress_markers.csv : 0.00 %
dihydroprogesterone.csv : 0.00 %
cyp2e1.csv : 0.00 %
p53.csv : 0.00 %
cyp1a1.csv : 0.00 %
selenium.csv : 0.00 %
hsc.csv : 0.00 %
osmolytes.csv : 0.00 %
floaters.csv : 0.00 %
pbmc.csv : 0.00 %
acetylcholine.csv : 0.00 %
asymmetric_dimethylarginine.csv : 0.00 %
triiodothyronine_levels.csv : 0.00 %
cortisol_levels.csv : 0.00 %
rituximab.csv : 0.00 %
d-limonene.csv : 0.00 %
resistant_starch.csv : 0.00 %
nadph_human.csv : 0.00 %
trpv.csv : 0.00 %
tinnitus.csv : 0.00 %
zinc_supplementation.csv : 0.00 %
chaperones.csv : 0.00 %
excitotoxicity.csv : 0.00 %
hpa_axis.csv : 0.00 %
tau.csv : 0.00 %
hgh.csv : 0.00 %
tmao.csv : 0.00 %
atrial_fibrillation.csv : 0.00 %
magnesium_deficiency.csv : 0.00 %
subclinicalhypo.csv : 0.00 %
o-glcnac.csv : 0.00 %
star.csv : 0.00 %
srd5a3.csv : 0.00 %
oxidative_stress_protection.csv : 0.00 %


Now that is interesting, cholestasis and NAFLD were towards the top.

car = constitutive androstane receptor
pxr=pregnane x receptor
rar = retinoic acid receptor
udpglcnac = uridine diphosphate N-acetylglucosamine
 
Last edited:

Gondwanaland

Senior Member
Messages
5,092
DH has 65 from 0 to 20% :(

The 0% is red +/- SLC6A12 rs557881
[PMID 21367462] Association between SLC6A12 gene and negative symptoms of schizophrenia in Korean population.
[PMID 20597903] Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population

He is not Korean :D
 

ppodhajski

Senior Member
Messages
243
Location
Chapel Hill, NC
DH has 65 from 0 to 20% :(

The 0% is red +/- SLC6A12 rs557881
[PMID 21367462] Association between SLC6A12 gene and negative symptoms of schizophrenia in Korean population.
[PMID 20597903] Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population

He is not Korean :D

Just a note, that just studied these in the Korean population. It does not mean it does not have the same effect in others.