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What did you find so remarkable, Crit? He is practically a twin of mineWow! Never seen this combination. What are your symptoms?
The forward path from folic acid to the methyl (methionine cycle) is largely unimpaired, and possibly in overdrive. I don't see that in any of the people here. I never see the MTR A2756G homogyzous without something going on in MTHFR C677T or MTRR A66G. (Yes I do see the other MTRRs, but they don't add up to much as I understand, and one is actually an accelerator there, too.)Wow! Never seen this combination. What are your symptoms? What supplements/Rxs have you tried and have you tolerated them? Have you ever had an amino acid panel done? That would be interesting with these SNPs.
The quest continues ....
Results from Genetic Genie.
Homozygous mutations;
MAO-A R297R
ACAT1-02
MTR A2756G
BHMT-02
BHMT-04
BHMT-08
Heterozygous mutations;
MTHFR A1298C
COMT V158M
COMT H62H
VDR Bsm
VDR Taq
MTRR H595Y
MTRR K350A
MTRR A664A
CBS C699T
@caledonia - what is that? I see the acceleration, but he's missing the MTRR A66G - only has the minor ones.You also have the B12 Double Whammy, so B12 is going to be an important supplement for you.
@caledonia - what is that? I see the acceleration, but he's missing the MTRR A66G - only has the minor ones.
Ok, that's what I saw, that he has two slow-downs and one speed-up MTRR, but not the major slow-down one. Thanks!MTR + MTRRs, but maybe not so bad if he's missing the major MTRR.
Heartfixer talks about the B12 double whammy.
On closer inspection, the homo MTR is probably a bigger issue.
In either case, B12 is going to be an important supp - note that he has neuropathy, which is a classic B12 deficiency symptom.