Dopamine is synthesized when needed, so I don't think there are any reserves to deplete.
Very low dose amisulpride (12.5 mg to 200 mg) does not actually increase dopamine levels, but rather activates the dopamine receptors, so this is like having elevated dopamine levels.
But higher doses of amisulpride do the reverse, and inhibit dopamine receptors.
If find 12.5 mg daily of amisulpride useful for several of my ME/CFS symptoms. Very low dose amisulpride activates the dopamine D2 and D3 receptors.
Activation of the D2 receptor on astrocytes
has been shown to reduce neuroinflammation.
5% of ME/CFS
were found to have autoantibodies to the dopamine D1 receptor, which will affect dopaminergic functioning.
To boost the dopaminergic system, you can either raise dopamine, activate (agonize) dopamine receptors, or you can take supplements or drugs like uridine or amantadine that actually create new dopamine receptors in the brain.
I posted a list of dopaminergic drugs and supplements
here.
I'd really like to find a drug that activates the dopamine D1 receptor, as this is associated with pleasure and reward, and I suffer from anhedonia (= lack of feeling pleasure and reward).