Anyone skillful people can help with my immune test results greeting from toronto

[darroo]

What are your thoughts? I also did lyme test before but its cross reacting the bands in my opinion with Bartonella, h.pylori but i hve a heat shock protein 58 kdA also + My uncle was diagnosed in canada or mycobacterium avium. I wonder if its related somehow and yes past mold exposure too a bit

Reference Range : Results

CD3+ - 0.600-0.770 = 0.744
Abs. CD3 0.960-1.800 = 1.940 High
CD3+CD4 0.320-0.480 = 0.378
Abs. CD3+CD4 = 0.535-1.125 = 0.985
CD3+CD8+ 0.180-0.350 = 0.303
Abs. CD3 + CD8 0.300-0.810 = 0.791
CD4/CD8 Ratio 0.80-2.80 = 1.25
CD19+ 0.080-0.210 = 0.081
Abs CD19 0.135-0.447 = 0.211
CH50 60.0 - 145.0 = 169.2 High
+++++++++++

IgM 0.46-3.04 g/L = 0.88
C3 0.79-1.52 g/L= 1.14
C4 0.16-0.38 g/L = 0.24
Rheumatoid Factor <20 kIU/L kU/L = <20

 

[SOC]

My main concerns are the CH50 is high and CD3 absolute count anyone else have those high?

Are you sure you want to post exact copies of your medical records with your name and other identifying information on it? This is a public searchable forum, so you are sending it out for the whole world to see.

You might want to just repeat the relevant info here without your name, doctor's name and such.

 

[darroo]

I don't mind . When your sick these things worry me the least

 

[SOC]

I don't mind . When your sick these things worry me the least

You probably should mind, especially if you're too sick to deal with the downstream consequences of putting large amounts of personal information out on the WWW.

You might also want to consider that most members are going to be unwilling to download files that could be contaminated or otherwise unwise to download. You'll probably get more responses if you just post your data.

Of course it's entirely up to you. End of internet safety lecture.

 

[darroo]

Ok I deleted it will upload results tomorrow in text form .

 

[darroo]

Reference Range : Results

CD3+ - 0.600-0.770 = 0.744
Abs. CD3 0.960-1.800 = 1.940 High
CD3+CD4 0.320-0.480 = 0.378
Abs. CD3+CD4 = 0.535-1.125 = 0.985
CD3+CD8+ 0.180-0.350 = 0.303
Abs. CD3 + CD8 0.300-0.810 = 0.791
CD4/CD8 Ratio 0.80-2.80 = 1.25
CD19+ 0.080-0.210 = 0.081
Abs CD19 0.135-0.447 = 0.211
CH50 60.0 - 145.0 = 169.2 High
+++++++++++

IgM 0.46-3.04 g/L = 0.88
C3 0.79-1.52 g/L= 1.14
C4 0.16-0.38 g/L = 0.24
Rheumatoid Factor <20 kIU/L kU/L = <20

 

[SOC]

Reference Range : Results

CD3+ - 0.600-0.770 = 0.744
Abs. CD3 0.960-1.800 = 1.940 High
CD3+CD4 0.320-0.480 = 0.378
Abs. CD3+CD4 = 0.535-1.125 = 0.985
CD3+CD8+ 0.180-0.350 = 0.303
Abs. CD3 + CD8 0.300-0.810 = 0.791
CD4/CD8 Ratio 0.80-2.80 = 1.25
CD19+ 0.080-0.210 = 0.081
Abs CD19 0.135-0.447 = 0.211
CH50 60.0 - 145.0 = 169.2 High
+++++++++++

IgM 0.46-3.04 g/L = 0.88
C3 0.79-1.52 g/L= 1.14
C4 0.16-0.38 g/L = 0.24
Rheumatoid Factor <20 kIU/L kU/L = <20

That mostly looks pretty normal. I haven't heard anything about high CH50 in ME/CFS. None of my immunology labs show that result unless it's under a different name. I hear that a high CH50 might indicate inflammation, but that result needs to be considered along with other test results and clinical picture before a conclusion could be drawn.

What does your doctor say about this? S/he has a better picture of your overall condition -- other labs, clinical picture -- than anyone here does. Any kind of diagnosis or conclusion needs to consider the big picture, not just one lab result. I would certainly ask him or her about the combination of high C3 and high CH50 as it might suggest a recent infection.

 

[darroo]

Im getting the treatment in canada alright, the psychiatic diagnosis lol.
They dont acknowledge any treament options and the doctor doesn't wanna run a CT scan to double check my lungs either.
im going to see KennyDe merlier next week to do more thorough testing. I already got diagnosis from environmental health clinic because i have autonomic dysfunction can't regulate body temperature over heating problems , delayed REM sleep. I have a score of 37 on the CFs score range and im 25. Excersice intolerance.

 

[Jonathan Edwards]

Dear @darroo,
I agree with SOC; these are essentially normal results. If your sed rate or CRP are normal I don't think the CH50 adds anything.

 

[darroo]

maybe auto immune issues then from all the past infections guess time will tell after i run more testings @ belgium

 

[darroo]

what about the borderline low cd19

 

[Jonathan Edwards]

what about the borderline low cd19

Very normal. B cell numbers vary widely in healthy people.

 

[darroo]

elevated ch50 suggests bacterial infections : http://www.igliving.com/magazine/articles/IGL_2015-12_AR_Defects-of-the-Complement-System.pdf

 

[darroo]

An elevated CH50 indicates high level of activity of the classical pathway of the complement system, but does not have any specific clinical meaning except suggesting the presence of active inflammation and immune activation.

 

[Jonathan Edwards]

An elevated CH50 indicates high level of activity of the classical pathway of the complement system, but does not have any specific clinical meaning except suggesting the presence of active inflammation and immune activation.

I think this is actually a bit misleading. A high CH50 means a high capacity to lyse sheep red cells - i.e. high levels of complement proteins ready to be activated. I think some complement proteins go up with the acute phase response so are up a bit when the CRP is up and the sed rate is up (mostly a sign of fibroinogen). So high CH50 does not mean 'high level of activity' or at least not high level of activation. It means increased capacity. Activation of the complement system uses up complement proteins so tends to leave you with a low capacity to lyse sheep cells with what you have left, if I remember rightly.

The level is only just above the top of reference. I don't think it means anything unless the CRP is raised, indicating an acute phase response - which need not be due to infection.

 

[darroo]

OK fair enough ,. but honestly all my muscles hurt, feverish , i think i have infection already long time that comes and goes, i moved already from old apartment since my friends diagnosis of mycobacterium avium and the mold too. If i have immune activation thats creating inflammation i want to get rid of it so i can have energy. i can't even go up stairs properly without having to cough... thats great if i have no issues , but an overly hyper immune system from reacting to environemntal issues i want to deal with it because its effecting my quality of life. I had in the past h pylori, bartonella from a cat scratch. and possibly mycobacteria particle exposure. My room mate was 58 years old diabetic whos doing treatment now with antibiotics. I take glutathione daily if i dont take it i feel bad.

 

[darroo]

Anyways thanks for your help everyone ... need to mention , i do feel better on antiobiotics azythromiacin but when i stop it over a period of X amoutn of time symptoms come back..

 

[darroo]

I think this is actually a bit misleading. A high CH50 means a high capacity to lyse sheep red cells - i.e. high levels of complement proteins ready to be activated. I think some complement proteins go up with the acute phase response so are up a bit when the CRP is up and the sed rate is up (mostly a sign of fibroinogen). So high CH50 does not mean 'high level of activity' or at least not high level of activation. It means increased capacity. Activation of the complement system uses up complement proteins so tends to leave you with a low capacity to lyse sheep cells with what you have left, if I remember rightly.

The level is only just above the top of reference. I don't think it means anything unless the CRP is raised, indicating an acute phase response - which need not be due to infection.

I haven't tested c reactive protein yet. Seeing him again in august.

 

[Jonathan Edwards]

I haven't tested c reactive protein yet. Seeing him again in august.

If you are worried about bacterial infection CRP would be the first thing on my list. If you have a problem with a mycobacterium I would expect it to stand out like a sore thumb. August seems a long way off to check for that.

 

[darroo]

yeah i know.. unfortunately im in canada free health care = long waiting times... and even then sometimes they choose to ignore certain things even lyme was ignored... if you have free time watch this

it explains about the salmon testing in vancouver.. and how the lab chooses to ignore other labs results... discusting


if you can apply this to our health care system you get an idea of what could happen will happen . long wait times too