D-ribose significantly helped with daily body pain. It tends to make me less of a grump, and perhaps by consequence when I am not in as much pain/grumpy and can concentrate better, I might be able to do slightly more. D-ribose is better than a pain pill for pain and doesn't come with the downside of lowering my brain or intracellular glutathione like aspirin/acetaminophen (tylenol).
I've heard some people have success with CoQ10 or Reduced CoQ10 (ubiquinone or ubiquinol). L-carnitine fumarate lowered my heart pain, but was not significant enough for me to make a continuous purchase. Acetyl-l-carnitine supposedly helps with brain function, but I'm not sure that's doing anything big for me.
I had some strange tiny, tiny gains on Cat's Claw/Samento for a little while. But I've had a bulls-eye rash with inadequate treatment, activity on band 39 and 41 on my past/present infection testing for Lyme, and a positive on past infection of babesia. I don't recommend taking any medications/supplements with Cat's Claw/Samento other than d-ribose and anything approved for a Lyme protocol. In general, Cat's Claw/Samento can mess with the "thickness" of your blood and might put you out of commission more than normal.
If you suspect Lyme, I'd suggest going on a "challenge" for a while and then testing maybe 1-1.5 months after through IgeneX. The co-infections can be tested via a regular lab; I haven't heard anything otherwise.
I've done some type of methylation protocol for around a year, both Rich's and a variation of Freddd's, with no noticeable gain. Oddly, I take it about every 2-3 days because it significantly lowers my ability otherwise. I plan on stopping once my bottles run out, as I suspect my glutathione will be fine for a while. I might restart again after 6 months.
I also take fish oil for mood and headaches. Sometimes, caffeine for headaches, concentration, energy (but mind serotonin level). Vitamin D to try to get my lower values up.
I don't think I've had a noticeable benefit from any other supplementation.