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The Histamine Gene rs10156191

Gondwanaland

Senior Member
Messages
5,092
My husband and I are respectively CT and CC.

But how about the DAO SNPs? We both are +/+ for one of them.
 

Gingergrrl

Senior Member
Messages
16,171
How do you find this histamine gene on 23andMe through Genetic Genie? Does it have a different name? Sorry for another dumb question!
 

drob31

Senior Member
Messages
1,487
How do you find this histamine gene on 23andMe through Genetic Genie? Does it have a different name? Sorry for another dumb question!

Click on Gondwanaland's link, and log in to 23andme.com, and it will show you the SNP's for the histamine gene.
 

Gingergrrl

Senior Member
Messages
16,171
Click on Gondwanaland's link, and log in to 23andme.com, and it will show you the SNP's for the histamine gene.

Can you see it on the Genetic Genie print out? I have never logged into 23andMe and not sure what you do?
 

Gondwanaland

Senior Member
Messages
5,092
I'm CC. And on the link from @Gondwanaland, I have 11, of which 9 are homozygous. Is this the source of my histamine issues??
Apparently not - I think +/+ MAO-A is enough reason ;)
Can you see it on the Genetic Genie print out?
Nope.
I have never logged into 23andMe and not sure what you do?
Username, password, raw data, then paste rs10156191 into SNP box or ABP1 into gene box.
Easier if just clicking the link on post #4 and logging in from there.
 
Messages
15,786
rs10156191 TT is pretty common: about 10% of people have that genotype, going up to 40% in some ethnic groups. It's a bit interesting, because according to the research at http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02548.x/full it's associated with down-regulation of the gene, but not associated with histamine intolerance at all.

It would seem to suggest that the down-regulation of the AOC1 gene caused by rs10156191 TT isn't sufficient to cause any problems. It's not too uncommon for that to happen on various genes.
 

drob31

Senior Member
Messages
1,487
rs10156191 TT is pretty common: about 10% of people have that genotype, going up to 40% in some ethnic groups. It's a bit interesting, because according to the research at http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02548.x/full it's associated with down-regulation of the gene, but not associated with histamine intolerance at all.

It would seem to suggest that the down-regulation of the AOC1 gene caused by rs10156191 TT isn't sufficient to cause any problems. It's not too uncommon for that to happen on various genes.

Thanks val. Do you base the SNP mainly on prevalence? I'm just wondering because I'm working with someone who is basing their research on the correlation with the SNP's in literature (pub med, etc), and not prevalence.
 
Messages
15,786
Thanks val. Do you base the SNP mainly on prevalence? I'm just wondering because I'm working with someone who is basing their research on the correlation with the SNP's in literature (pub med, etc), and not prevalence.
No, the research is more important. But it's unlikely a genotype for a SNP is causing much mayhem when it's present in 10% of the world's population :p
 

drob31

Senior Member
Messages
1,487
tDUzbsKxhbx38E4erKnZ5A_triad-right.gif
ABP1 150553605 rs10156191 C or T
TT

tDUzbsKxhbx38E4erKnZ5A_triad-right.gif
ABP1 150554157 i6025303 A or G
GG

tDUzbsKxhbx38E4erKnZ5A_triad-right.gif
ABP1 150554553 rs1049742 C or T
CC

tDUzbsKxhbx38E4erKnZ5A_triad-right.gif
ABP1 150554798 i6056406 C or T
CC

tDUzbsKxhbx38E4erKnZ5A_triad-right.gif
ABP1 150554995 rs45558339 A or G
GG

tDUzbsKxhbx38E4erKnZ5A_triad-right.gif
ABP1 150557665 rs1049793 C or G
CG

tDUzbsKxhbx38E4erKnZ5A_triad-right.gif
ABP1 150557707 rs35070995 A or C
AA