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Genetic Markers for PTSD Linked to Immune System Response

Wayne

Wayne

Senior Member
Messages
4,307
Location
Ashland, Oregon
I've long thought that many pwCFS (including myself) are likely dealing with some degree of PTSD. This report connecting immune system regulation with PTSD seems to support that thesis.
Researchers have identified genetic markers associated with post-traumatic stress disorder (PTSD) that are linked with regulating the immune system, Medical News Today reported. This finding may lead to the ability to identify individuals at risk of PTSD.
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Genetic Markers for PTSD Linked to Immune System Response
 
ahmo

ahmo

Senior Member
Messages
4,805
Location
Northcoast NSW, Australia
When I was at my worst, with overwhelming neurological symptoms, I was triggered by everything in my environment. My life wasn't a utopia, there were stressful aspects to my childhood, but there was no specific traumatic event. I definitely reacted to my world as if I had PTSD. I think it was this that convinced the examining psychologist to grant my appeal for disability. Since my nervous system, as well as inflammatory system, have calmed during the past 3 years, I'm no longer experiencing this.
 
Gemini

Gemini

Senior Member
Messages
1,176
Location
East Coast USA
Wayne said:
Today's CNN article:

Is post-traumatic stress disorder in your genes?
Click to expand...

Thanks for posting this interesting article @Wayne!

Interferon has long been studied re: ME/CFS, early researchers feeling high levels caused many of the symptoms.

Fast forward to Dr. Kerr's genetic study where Interferon genes topped the list.

RA research now suggests Interferon gene expression signatures can predict response to Rituxan.

@ahmo I wonder if high interferon levels caused the feelings of PTSD you describe?
 
student

student

Senior Member
Messages
166
Yes, these BH4-genetics (here TPH-2) and neurotransmitter (comt) disorders can lead to depression. I was hoping to see more details…

Appart from this understanding, we do look for a much broder spectrum: In 1. methylation (cbs), the 2. Folate (MT‘s / mtRR), 3. Neurotransmitters (BH4, comt / UGT), 4. Cortisol pathway (NR3) and others perhabs at 5. Amonium, and verry verry crucial 6. Glutathion (GST) and Nitrox (with SOD2) for cleaning up. Perhabs later 7. can be relevant for psycho-medications - Cytochrom (Cyp). All these disorders in your snp’s can trap @CFS.

See: Schnakenberg E. humangenetics, biologie. Genetsches Muster bei CFS, notwendige Untersuchungen. CFSme Forum german. Zeitschrift fatigo 2014. 36: page 16.

And some of us would not have dared to join healthy mariens @Wayne 's studie.
 
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