Medscape Medical News
Fibromyalgia Imaging Study Shows Unique Brain Connectivity
Jenni Laidman
February 10, 2015
[QUOTE
A new brain imaging study reveals that patients with fibromyalgia (FM) show unique brain activity in response to pain.
The patients had increased connectivity between the primary region of the brain that recognizes touch,
the S1 somatosensory cortex, and a second region that assigns salience to stimuli, the anterior insula.
The results suggest "a neurobiological substrate for evoked pain hypersensitivity in FM," the authors report.
In the study, published online January 26 in Arthritis & Rheumatology
This paper highlights the fact that the somatosensory cortex and connectivity to the insula
related to pain administered in the study is also related to clinical pain," Dr Harris told Medscape Medical News.
"This suggests that the fMRI outcome is also related to clinical pain."
][/QUOTE]
http://www.medscape.com/viewarticle/839524
abstract
The somatosensory link: S1 functional connectivity is altered by sustained
pain and associated with clinical/autonomic dysfunction in fibromyalgia
[QUOTE
Conclusion: Our study demonstrates that both somatic and non-somatic dysfunction in FM, including clinical pain,
pain catastrophizing, autonomic dysfunction, and amplified temporal summation, are all closely linked with the
degree to which evoked deep-tissue pain alters S1 connectivity to salience/affective pain processing regions.
Additionally, diminished connectivity between S1 subregions at REST in FM may result from ongoing
widespread clinical pain. This article is protected by copyright. All rights reserved.
][/QUOTE]
http://onlinelibrary.wiley.com/doi/10.1002/art.39043/abstract
Fibromyalgia Imaging Study Shows Unique Brain Connectivity
Jenni Laidman
February 10, 2015
[QUOTE
A new brain imaging study reveals that patients with fibromyalgia (FM) show unique brain activity in response to pain.
The patients had increased connectivity between the primary region of the brain that recognizes touch,
the S1 somatosensory cortex, and a second region that assigns salience to stimuli, the anterior insula.
The results suggest "a neurobiological substrate for evoked pain hypersensitivity in FM," the authors report.
In the study, published online January 26 in Arthritis & Rheumatology
This paper highlights the fact that the somatosensory cortex and connectivity to the insula
related to pain administered in the study is also related to clinical pain," Dr Harris told Medscape Medical News.
"This suggests that the fMRI outcome is also related to clinical pain."
][/QUOTE]
http://www.medscape.com/viewarticle/839524
abstract
The somatosensory link: S1 functional connectivity is altered by sustained
pain and associated with clinical/autonomic dysfunction in fibromyalgia
[QUOTE
Conclusion: Our study demonstrates that both somatic and non-somatic dysfunction in FM, including clinical pain,
pain catastrophizing, autonomic dysfunction, and amplified temporal summation, are all closely linked with the
degree to which evoked deep-tissue pain alters S1 connectivity to salience/affective pain processing regions.
Additionally, diminished connectivity between S1 subregions at REST in FM may result from ongoing
widespread clinical pain. This article is protected by copyright. All rights reserved.
][/QUOTE]
http://onlinelibrary.wiley.com/doi/10.1002/art.39043/abstract