I've had this wired symptom for years. The only thing which helps tremendously for me is being outside in the cold for 10-15 mins. All you need is a part of your head exposed to the cold.
Very interesting. Like resetting something.
This symptom began as an intermittent one for me, but as nerve damage and associated symptoms progressed, it has become chronic. My latest flare began with a very long and stressful dental surgery, followed by another surgery a month later. That was 6 months ago. Symptoms had increased incrementally since then, engaging some kind pathologic self-generating metabolic loop (the worse it got the worse it got).
By yesterday it had become extremely uncomfortable and without let-up - much like others on this thread have described. It is like all my veins are vibrating non-stop, plus there is a sick nervous system feeling, depressed mood (not depression), increased fatigue, a heightened awareness (for me) of systemic nerve damage, feeling of lack of any homeostasis, tightness in my chest and back - vibrating sensation there too, a feeling of insufficient breath. It definitely feels neuroendocrine in nature but not specific to any one system.
I may have inadvertently contributed to the problem by eating more fermented foods around the same time as the stressful surgeries that triggered this one, because glutamic acid is another source of these symptoms for me. Where I had previously tolerated fermented foods in moderation, once sensitized I seemed to become hyper-sensitized more than usual to things I seemed to be tolerating previously.
For me, the intensity and duration of these symptoms is an indication of how much new nerve damage is occurring. For instance, I have lost more feeling in my fingers over the past 4 months, and the skin on my fingertips and nails have died back further.
I had tried gabapentin at prescribed 300mg, half doses, and less. It did nothing for any of my symptoms and at standard and half doses also make me feel like crap. When I tried much smaller amounts I noticed nothing good or bad. I don't know it's even supposed to be useful for non-painful conditions (mine is the opposite of pain).
I have tried many things for this, including balancing electrolytes and minerals, B12, B12 + folinic or Mfolate + other active forms of Bs and all kinds of other things. Everything made it worse or had no effect.
And then I woke this morning and the vibrating sick nervous system feeling was gone. It had gone from its worst to nothing but a few artifacts, probably of damage that cannot be repaired or will take time. This was even more remarkable in that the vibrating sensation has almost invariably been worse on waking each morning than on going to sleep.
Last night I took 3 capsules of ashwagandha (KSM-66, 250mg /5%withanolides). I had never tried it and because of a history of bad reactions to things, I had started the previous week with several small doses daily, maybe a half capsule at most. I don't think I had tried a whole cap yet but last night I was feeling so horrible and hopeless about this that I took 3 over a period of 30-60 minutes. Although I had had some trouble falling asleep initially, I slept well for 6 1/2 to 7 hours.
Dosing instructions say 1-2 times /day. I had thought of waiting until symptoms returned to take more but then decided to take one this afternoon and another this evening. I don't want the symptoms to get a toe hold, but I don't want to overdo a good thing. It's not as if each of the components of an herbal extract can be instructed to follow the same schedule of effects, or in individuals with different metabolisms. Finding a dosing schedule will be a problem even barring any major setbacks. One is coming up next week - more surgery.
