Marco
Grrrrrrr!
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This is the full text of an oral presentation so not much more than an abstract but very interesting especially as regards children who were not likely to be exposed to the usual causes of peripheral neuropathy (diabetes, infections, cancer or toxins) implicating autoimmunity.
Small-fiber polyneuropathy (SFPN), a common underlying diagnosis in syndromes involving unexplained chronic pain and multi-system symptoms
"Among adults with fibromyalgia, 41% of skin biopsies from subjects with fibromyalgia vs. 3% of biopsies from controls were diagnostic for SFPN, and symptom and examination scores were higher in fibromyalgia subjects than in controls (all P ≤ 0.001) [10]. All fibromyalgia patients diagnosed with SFPN then had blood tests for all known causes [8]. None had diabetes but 62% had test-results consistent with dysimmunity, and some had genetic causes [10]. Other laboratories have now also linked fibromyalgia to SFPN"
(bolding added)
http://www.molecularpain.com/content/10/S1/O12
Although mentioned as an example of a syndrome involving unexplained chronic widespread pain and mutisystem symptoms they didn't include a ME/CFS cohort. But the implication is that SFPN can cause these symptoms (including autonomic dysfunction) in older adults, that SFPN is found in a high proportion of fibromyalgia patients and in young people with chronic multisystem symptoms the presence of SFPN can't be explained by the usual causes.
I would really like to see objective testing for SFPN of a ME/CFS cohort :
http://www.cortjohnson.org/blog/201...treatment-widespread-pain-fibromyalgia-mecfs/
Small-fiber polyneuropathy (SFPN), a common underlying diagnosis in syndromes involving unexplained chronic pain and multi-system symptoms
"Among adults with fibromyalgia, 41% of skin biopsies from subjects with fibromyalgia vs. 3% of biopsies from controls were diagnostic for SFPN, and symptom and examination scores were higher in fibromyalgia subjects than in controls (all P ≤ 0.001) [10]. All fibromyalgia patients diagnosed with SFPN then had blood tests for all known causes [8]. None had diabetes but 62% had test-results consistent with dysimmunity, and some had genetic causes [10]. Other laboratories have now also linked fibromyalgia to SFPN"
(bolding added)
http://www.molecularpain.com/content/10/S1/O12
Although mentioned as an example of a syndrome involving unexplained chronic widespread pain and mutisystem symptoms they didn't include a ME/CFS cohort. But the implication is that SFPN can cause these symptoms (including autonomic dysfunction) in older adults, that SFPN is found in a high proportion of fibromyalgia patients and in young people with chronic multisystem symptoms the presence of SFPN can't be explained by the usual causes.
I would really like to see objective testing for SFPN of a ME/CFS cohort :
http://www.cortjohnson.org/blog/201...treatment-widespread-pain-fibromyalgia-mecfs/