Marco
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Abstract of a small study that proposes beneficial effects of phenylephrine (alpha adrenergic receptor agonist used for hypotension) on orthostatic challenge induced reduced cerebral blood flow and impaired cognition :
Phenylephrine Alteration of Cerebral Blood Flow During Orthostasis; Effect on N-Back Performance in Chronic Fatigue Syndrome
http://jap.physiology.org/content/early/2014/09/30/japplphysiol.00527.2014
Phenylephrine Alteration of Cerebral Blood Flow During Orthostasis; Effect on N-Back Performance in Chronic Fatigue Syndrome
CONCLUSIONS:
Compared to control, CFS subjects are both more sensitive to orthostatic challenge and to baroreflex/chemoreflex-mediated interventions. Increasing BP with phenylephrine can alter CBFv. In CFS subjects, mitigation of the HUT-induced CBFv decrease with phenylephrine has a beneficial effect on N-Back outcome.
http://jap.physiology.org/content/early/2014/09/30/japplphysiol.00527.2014