23andme, b12, vitamin d3, pyroluria tests

[LivingwithFibro]

Hi everyone, I have several questions about testing today:

1) Is it useless to get a b12 blood test done if one cannot get a full methylation panel (whatever it is called)?

2) What are the tests one can get for Pyroluria? Will a simple Zinc, b6, b3 test tell me if I have Pyroluria?

3) What good will it do to me, I mean what kind of information will I gain from a simple $100 test from 23andme for MTHFR/methylation problem? Is it necessary or is getting a full methylation panel from Dr Amy Yasko better to find out everything about your methylation problems or if you indeed have MTHFR. Will it tell me if I am deficient in GSH?

4) Will testing of all the b-vitamins help me narrow things down or explain my methylation problems?

I have FIBRO, symptoms of CFS, IBS, been underweight since Iwas a child (77 pounds) and a doctor thinks I have Lyme disease which is the culprit behind this but some symptoms simply do not match... I feel MTHFR may be responsible for all these ailments and I thought it would be best for me to see if my methylation cycle is working before starting another detox diet or taking supplements to fix the problems without knowing anything...

 

[LivingwithFibro]

Oh and is it possible to have Fibromyalgia, CFS, IBS and not have a genetic mutation?

 

[ahmo]

B12 blood tests don't necessarily reveal B12 deficiency for several reasons. Sorry I can't be more concrete. One, folic acid can mask B12 deficiency. 2, I think, is serum B12 is an inaccurate measure of what's in the cells.

You can start a methylation protocol w/o doing any tests. If you get some results, you can continue. 23andme can alert you to genetic defects that might interfere w/ your methylation efforts, but these results are not critical to you beginning. I'm linking some methylation vids that might be helpful. In my signature is a Methylation for Dummies article from a blog of someone w/ lyme. So you can read the article and also get her info re Lyme.

There are likely many more people ill w/ the range of ME/CFS/Fibro ailments than those who've been tested. Re numbers w/ mutations,

I posted the following links recently...could have been to you, I have a poor memory

I uncovered my pyroluria by taking this questionnaire only. And successfully treated with the supps. Lab tests for pyroluria are notoriously unreliable, must be done under very specific conditions.

http://www.hputest.nl/evraag.htm Online questionnaire to suspect pyroluria

Klinghardt Pyroluria
http://www.klinghardtacademy.com/images/stories/powerpoints/hpu 2009.pdf

Klinghardt: Autism, Lyme, Pyroluria
http://www.youtube.com/watch?feature=player_detailpage&v=-z3kRDYcvhA

howirecovered.com/active-b12-therapy-faq/

http://beyondmthfr.com/tag/mthfr/ video series on SNPs

mthfr.net

 

[PeterPositive]

Hi,

1) Is it useless to get a b12 blood test done if one cannot get a full methylation panel (whatever it is called)?

B12 blood levels are almost useless. Many deficiencies are not found via blood tests because it doesn't say anything about your ability to transport and use B12.

2) What are the tests one can get for Pyroluria? Will a simple Zinc, b6, b3 test tell me if I have Pyroluria?

In theory if you find low levels of those nutrients you may suspect Pyroluria, but it could just be a generic deficiency due to bad diet, high oxidative stress etc...

Serum HPL/Kryptopyrrole will tell you if you have elevated "mauve factor" (aka pyroluria)

You can order a test in one of these labs:
http://www.hdri-usa.com/ (USA)
http://www.europeanlaboratory.nl/ (EU)

3) What good will it do to me, I mean what kind of information will I gain from a simple $100 test from 23andme for MTHFR/methylation problem? Is it necessary or is getting a full methylation panel from Dr Amy Yasko better to find out everything about your methylation problems or if you indeed have MTHFR. Will it tell me if I am deficient in GSH?

23andme can help but it won't tell you how is your methylation working right now.
For that you need a functional test. The labs I have linked provide a pretty comprehensive methylation panel that will tell you about GSH, SAMe, SAH, folate status etc...

4) Will testing of all the b-vitamins help me narrow things down or explain my methylation problems?

No, it is unlikely. They may help finding ongoing deficiencies though.

Cheers