Discuss SNP rs1464510 Celiac, gliadin, gluten related SNP

[roxie60]

Curious if anyone has their SNP rs1464510 info, I am AA on 23andMe. Anyone know if this is the risk allele? Is AA and TT always the risk allele? TIA

 

[Dreambirdie]

I am AA, and clueless about what this means...?

I am used to thinking in terms of + - and not in terms of letters.

 

[roxie60]

I understand . Trying to find out if AA is +/+ or -/- .

 

[Dreambirdie]

I hope someone has answer.

Yooo---hoooo! Anybody here? We're lost in the wilderness of alleles.

 

[roxie60]

http://www.snpedia.com/index.php/Rs1464510 the risk allele is 'A'.

 

[Dreambirdie]

So AA essentially means ++ which makes sense.

I do think I am gluten sensitive. I haven't eaten it for a long while.

 

[drex13]

I'm Hetero, AC, for whatever that's worth.

 

[roxie60]

I am also gluten/gliadin sensitive but my blood celiac test was negative (of course my blood never shows much of anything). Neurologist said the celiac blood test is about 20-30% false negative - this however is not what i found in pubmed? their info said the false neg was about 1%, big difference, I have lost faith in Drs so it doesnt matter).

Hi drex13, could just mean you carry one gene that 'might' make you gluten sensitive.

 

[snowathlete]

I'm Hetero, AC, for whatever that's worth.

snap.
negative celiacs blood test too.

 

[Phred]

I have Celiac. <waves frantically> I came up hetero AC as well on this test. There are 22 or 23 genes associated with Celiac though. 23andme only tests one.

roxie60 the 20 - 30% false negative your neurologist quoted is probably about right. Doctor's love to only test Igg or IgA antibodies. Then they don't check to see if the IgA is low. If it's low already you'll get a false negative. My doc only checked Igg. I didn't have the antibodies. I was diagnosed through endoscopy (found villous atrophy) and positive response to gluten free diet. Doctors need to do a FULL Celiac panel to rule out the disease and that is far too often not done.

Also Celiac is genetic, but it's triggered. So if you have the gene, but it hasn't been triggered yet, you're not making antibodies. If you're not making the antibodies it won't show up on blood work.

That's my quick lesson on Celiac. There's also NCGI (non celiac gluten intolerant) and fun stuff like gluten ataxia. Hope that's all clear as mud.

 

[roxie60]

so far it looks like we are batting 100% - if people have one or two of the risk allele 'A' they are reporting being Celiac or gluten sensitive (unless I misread anyones post, apologies if I did ).

 

[Skyline]

I'm CC - and seem to have issues with gluten. I'm currently exploring that being a mold related biotoxin issue and the immune response.

 

[roxie60]

A number of alleles now being associated with Celiac. I'm still struggling on homozygous alleles ow to determine the risk allele. For instance the report below I am homozyg on a few but not the version listed, e.g. the report will ident A as the risk allele/version but I am GG, so do I change the GG to AA?

http://blog.23andme.com/23andme-res...ared-genetic-factors-for-autoimmune-diseases/

 

[roxie60]

Here is another report. Sorry if it overlaps, I cant even swap screens and remember what I saw to compare - tired

http://blog.23andme.com/23andme-res...liac-disease-share-some-genetic-risk-factors/

Still tryig to fogure out when one swap A-G and T-C to determine ones risk allele status

 

[roxie60]

here is another list of Celiac related SNPs from SNPedia

http://www.snpedia.com/index.php/Celiac_disease

 

[MogMog]

I am trying to find out if I have coeliac disease or am gluten intolerant. I am going to get the 23 and Me test done sometime but I am also considering the gluten gene test from Kimball Labs:

http://www.kimballgenetics.com/files/Celiac_HLA_DQA-DQB_flyer_2013.pdf

Am I right that I will get more genetic information on gluten/coeliac from this Kimball test than from the 23andme test?

 

[Valentijn]

23andMe is pretty bad for testing HLA types. But even HLA type isn't completely determinative of having celiac or gluten intolerance. Blood testing and/or biopsy is probably needed for celiac, and IgA testing and food elimination trial is probably needed to determine gluten intolerance.

 

[ukxmrv]

I saw this posted to Facebook recently on the "Chronic Fatigue Syndrome Research Center at Stanford University" page

And here is our first Question and Answer post!!

Question: What are possible examples of findings that could be found in this type of research and how could this translate to validating the illness and lead to future treatments?

Answer from Dr. Davis: One example of findings is from genetic analysis. If we can find gene variants that are more common in CFS than non-CFS or other diseases, then the altered function of these versions of the genes may increase the chances of onset of CFS. This could tell us who is at greater risk. It could also give clues for treatment. We are sequencing the DNA of the HLA region from patients with CFS (and controls). The sequence of the HLA region often predicts susceptibility to disease.

 

[MogMog]

My IgA is low (0.5) so I worry that a lot of the blood testing for coeliac will be inaccurate. I had a negative on the coeliac test my GP did, but it is IgA based. I tried to get an IgG test but GP said no, that the IgA test result was okay because my IgA was low but not deficient. Don't know if that's right or not. I'm going to ask for the biopsy but I doubt that he is going to agree - despite my gut symptoms which he is ignoring.
Are there any other private tests accurate for coeliac / gluten intolerance, not based on IgA?
Enterolab does a faecal fat absorption test that's supposed to show villi damage, presumably an alternative to a biopsy?

 

[nandixon]

Some of the SNPs 23andMe tests for correspond to "tagging" SNPs for the HLA genes that relate to celiac disease. Thus you can use your SNP results to strongly infer your HLA results. See this SNPedia link and the references contained within for a list of the SNPs:

http://www.snpedia.com/index.php/Celiac_disease