Hip
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@Leopardtail
I would not have thought that the absorption of a medication into cells or the extracellular spaces would make much difference to the plasma half life, except during the first few days of starting a medication. But after the first few days on a regular dose of the medication, the absorption of the medication from the plasma into the intracellular and extracellular spaces will reach equilibrium, and then these intracellular and extracellular spaces will stop absorbing the medication, and thus they will no longer be a "sink" for the medication. At that point of equilibrium, the only sinks are metabolization and elimination through the kidneys or bowels.
I would not have thought that the absorption of a medication into cells or the extracellular spaces would make much difference to the plasma half life, except during the first few days of starting a medication. But after the first few days on a regular dose of the medication, the absorption of the medication from the plasma into the intracellular and extracellular spaces will reach equilibrium, and then these intracellular and extracellular spaces will stop absorbing the medication, and thus they will no longer be a "sink" for the medication. At that point of equilibrium, the only sinks are metabolization and elimination through the kidneys or bowels.