Ema
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I read a blog where a woman did a clinical study using leptin injections. I'll have to try to find that again. It was interesting. She lost quite a bit of weight if I remember correctly.I would guess not re oral supplementation, as it is a protein and will be mostly or completely broken down by stomach acid before it gets to where you need it. Injection, maybe, but maybe not available yet. Also, per this page, it seems that problems are sometimes due not to a lack of leptin but to insensitivity to it.
Dr Kruse (I know) says that it isn't the absolute leptin level...it's the sensitivity to it. So the obese have high leptin and leptin insensitivity and the bulemic/anorexic have low leptin and also are leptin insensitive. It's all about restoring sensitivity in his view and restoring proper thyroid and HPA axis function.
Good basic leptin article here:
What’s in a Name? In Search of Leptin’s Physiologic Role
http://press.endocrine.org/doi/abs/10.1210/jcem.83.5.4779?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed