H.pylori-Hypochlorhydria-Dysbiosis-Liver-CFS/ME Connection

[Radio]

The CFS/ME puzzle...
I think Fred Davis is on point with regards to methylation. RichVank did understand that there was more to this syndrome than just a methylation block and glutathione depletion.

The missing link to CFS/ME puzzle in my opinion is Hypochlorhydria / Dysbiosis and the domino affects goes on and on and on. I also believe we have a weak liver genotype that contributes to these matrix of deficiencies. Yes we have a disease my friends, that not only damages the mitochondria cells. It also affects the kidney, brain and liver as well.


Hypochlorhydria + Dysbiosis = Acquired Mitochondrial Disease


Hydrochloric acid insufficiency could be the main contributing factor to the bacteria over-growth we are seeing and dramatically reduce stomach acid production. I believe we have genetic factors as well as environmental issues that make us vulnerable to this illness.


Can Helicobacter pylori cause low stomach acid?


H-pylori is a deep rooted infection that is very hard to eradicate. H-pylori can lead to a Gastritis inflammation of the stomach lining that can also develop into hypochlorhydria that can deplete the stomach ability to produce hydrochloric acid. We need stomach acid to protect and heal and repair the body. The research I have done has pointed to poor liver function and low stomach acid as risk factors in many chronic illnesses we see today.


Can Hypochlorhydria / HCL insufficiency be related to silent organ damage?


I am convinced that the toxic waste produced by the dysbiosis imbalance can be very damaging, especially when we are not methylating RNA, DNA and phosphatidylcholine. HCL insufficiency can cause minerals and lipids to be deficient. Also, manganese, zinc and choline are essential for the health of the liver and the mitochondria function. The body needs (HCL) to achieve the correct (pH) flora balance. Stomach acid is also required to liberate vitamin B12 from food. There are also many genetic variations that contribute to the liver detoxification capacity that could be a factor.



Radio: What can cause the Hypochlorhydria problem?

• The slowing of the body's basal metabolic rate associated with hypothyroidism
• Autoimmune disorders where there is antibody production against parietal cells which normally produce gastric acid.
• The use of antacids or drugs that decrease gastric acid production (such as H2-receptor antagonists) or transport (such as proton pump inhibitors).
• A symptom of rare diseases such as mucolipidosis (type IV).
• A symptom of Helicobacter pylori infection which neutralizes and decreases secretion of gastric acid to aid its survival in the stomach.[1]
• A symptom of pernicious anemia, atrophic gastritis or of stomach cancer.
• Radiation therapy involving the stomach.
• Gastric bypass procedures such a duodenal switch and RNY, where the largest acid producing parts of the stomach are either removed, or blinded.
• VIPomas (vasoactive intestinal peptides) and somatostatinomas are both islet cell tumors of the pancreas.
• Pellagra, caused by niacin deficiency.

See more at: Hypochlorhydria / Wiki
http://en.wikipedia.org/wiki/Achlorhydria

Hypochlorhydria?

Stomach acid assessment
http://www.drdebe.com/self-tests/stomach-acid-assessment
Salivary test for Hypochlorhydria
http://drmyhill.co.uk/wiki/Vascular_endothelial_growth_factor_(VEGF)-_salivary_test_for_hypochlorhydria
Hypochlorhydria lack of stomach acid - can cause lots of problems
http://drmyhill.co.uk/wiki/Hypochlorhydria_-_lack_of_stomach_acid_ _can_cause_lots_of_problems
Hypochlorhydria: A Review, parts 1 & 2
http://drmanlove.com/diet-and-nutrition-articles/low-stomach-acid.html
Gastritis / Wiki
http://en.wikipedia.org/wiki/Gastritis
Atrophic gastritis
http://en.wikipedia.org/wiki/Atrophic_gastritis

What is Atrophic Gastritis?
Atrophic gastritis (AG) is a condition that develops when the stomach’s lining has been inflamed for many years. The inflammation is most often caused by an infection of the bacterium H. pylori. The infection gradually destroys cells in your stomach lining. It is thought that the bacteria cause inflammation by disrupting the barrier of mucus that protects your stomach lining from the acidic juices that help it digest food. Less often, AG occurs because your immune system mistakenly attacks the cells in your stomach lining. This is known as autoimmune atrophic gastritis. See more at: http://www.healthline.com/health/atrophic-gastritis#Description

Radio: How can we test for gastritis?

Using a scope to examine your upper digestive system (endoscopy). During endoscopy, your doctor passes a hollow tube equipped with a lens (endoscope) down your throat and into your esophagus, stomach and small intestine. Using the endoscope, your doctor looks for signs of inflammation. If a suspicious area is found, your doctor may remove small tissue samples (biopsy) for laboratory examination. See more at: http://www.mayoclinic.org/diseases-conditions/gastritis/basics/tests-diagnosis/con-20021032

Radio: What are H.Pylori main symptoms?

Many people with Helicobacter pylori bacteria have no outright symptoms which might be typical of H-Pylori, such as abdominal pain or ache, nausea, vomiting, frequent belching, or weight loss. Others may have symptoms that are more subtle, causing dysfunction of other functions of the body.
Helicobacter Pylori: Not Just A Third World Problem? http://www.stopthethyroidmadness.com/h-pylori/

Radio: How can H.pylori damage the body?

Damage it can cause include:

Absorption issues, Food allergies/sensitivities, Seasonal Allergies, Vitamin and mineral deficiencies, especially: B12, iron, vitamin D, lactoferrin, Autoimmune issues, Fatigue, Adrenal stress, Lowered thyroid hormone conversion, Elevated Histamine levels, Chronic infection, Parasites.

Low stomach acid
Ketosis, Neurotransmitter imbalance, including GABA, Liver and Gallbladder issues

Peptic UlcerCancers of the stomach, liver or cervix
Teeth and sinus problems
Cancers of the stomach, liver and cervix
Teeth and sinus problems
Additionally, h-pylori can cause the following problems:

• H. pylori lowers Stomach Acid:

http://www.ncbi.nlm.nih.gov/pubmed/9207257
http://www.healingnaturallybybee.com/articles/dig10.php

• H. pylori impairs Iron Absorption:

http://www.ncbi.nlm.nih.gov/pubmed/15285524

Coincidentally, lactoferrin supplements can help eradicate H.pylori and raise iron levels as well.
http://www.ncbi.nlm.nih.gov/pubmed/14620619
http://www.healthyfellow.com/309/lactoferrin-and-anemia/

Stopthethyroidmadness.com/h-pylori
http://www.stopthethyroidmadness.com/h-pylori/

Radio: Can H.pylori cause mineral depletion?

H-pylori can block the absorption minerals and neutralizing stomach acids. The body has a preference for minerals. For example, the body prefers Zinc for over 50 critical enzymes. However, if Zinc becomes deficient (which is very common) or exposure to Cadmium, Lead or Mercury is sufficiently high, the body will use these toxic minerals in place of Zinc. When H. pylori infection decided to make a home in your body, it needs certain materials to do that. It needs to neutralize acid. It needs certain vitamins (B-12 is one of them). It needs to make enzymes to help keep it alive, its enzymes use up manganesm leaving the body deficient in manganese. Manganese is needed to fight free radicals. Without it cell membranes and the DNA are damaged. - See more at: http://www.mygutsy.com/is-h-pylori-...sorders-adrenal-fatigue/#sthash.1KzwEYym.dpuf

Get the right H. pylori test
http://www.ulcer-cure.com/index.php/h-pylori/all-about-h-pylori/getting-an-accurate-h-pylori-test





Radio: How can H.pylori affect the biochemical process in the body?

If you don’t know anything about h. pylori I suggest you watch these video’s. I have done lots of research over the past months and these videos are very detailed and explain the biochemical process your body goes through and what the h. pylori does (what vitamins it takes away, detox pathways it ruins, etc..) to the body. I wont lie- they are long, but if you are serious about eradicating the h.pylori for good, then you need to know your facts.

h. pylori- another piece to the puzzle

h. p- part 2

I find Dr. Amy is a very thorough Dr. and researcher and her protocol and testing techniques actually work. Here is her site.


See more about H-pylori info at, http://www.mygutsy.com/is-h-pylori-...sorders-adrenal-fatigue/#sthash.1KzwEYym.dpuf

Helicobacter Wiki
http://en.wikipedia.org/wiki/Helicobacter_pylori




Radio: What is stomach acid role in beneficial bacteria?

In order for any pathogen to enter your small intestine via the stomach it has to survive stomach acid. Stomach or hydrochloric acid is there to not only begin the digestion of protein, but to kill any pathogens ingested with food or present in saliva before they take up residence in your gut and cause dysbiosis. At a pH of 4, most bacteria are killed within 30 minutes, but the pH of a normal human stomach is an even more acidic 2. That means that 99% of bacteria are killed within 5 minutes of entering the stomach. This is why relying on yogurt or kefir to quickly repopulate your gut with beneficial bacteria isn’t going to happen. If it did, you would have much bigger problems.

Therefore, it follows that anything that compromises this very important gastric barrier is going to predispose you to SIBO.


Other causes of impaired gastric barrier function include H. pylori infection, malnutrition and various autoimmune diseases like pernicious anemia. Gastric surgeries like gastrectomy (partial or full removal of the stomach) and truncal vagotomy (resection of the vagus nerve) can also cause SIBO by either raising stomach pH, preventing its production or impairing motility.

Small-intestinal-bacterial-overgrowth
http://syontix.com/small-intestinal-bacterial-overgrowth-part-three-gastric-barrier-dysfunction/

Radio: Can gut micro-imbalances contribute to liver disease?

Microbes that reside in colons of obese individuals produce many compounds that could contribute to development of non-alcoholic fatty liver disease (NAFLD) and other complications of obesity, according to a study published in the July issue of Clinical Gastroenterology and Hepatology.

Microorganisms living in the human intestine (gut microbiota) affect digestion, energy metabolism, inflammatory signaling pathways, and even liver function. Changes in the gut microbiota have been associated with obesity, diabetes, metabolic syndrome, and liver disease. The microbiota of obese individuals has been reported to have less diversity and altered concentrations of specific types of microbes, compared with lean individuals.

Chronic excessive ingestion of ethanol produces liver steatosis, steatohepatitis, and cirrhosis. Gut microbes are an endogenous source of ethanol, which can be continuously delivered to the liver. The microbes also produce about 300 other volatile organic compounds (VOCs), but little is known about their effects on liver or other organs.
How Can the Gut Microbiota Contribute to Liver Disease?
http://agajournals.wordpress.com/2013/07/08/how-can-the-gut-microbiota-contribute-to-liver-disease/

The Intestinal Microbiota and Liver Disease
http://www.nature.com/ajgsup/journal/v1/n1/full/ajgsup20123a.html
The-gut-microbiota-and-the-liver pdf
http://doctorsonly.co.il/wp-content/uploads/2013/05/The-gut-microbiota-and-the-liverjhep5.13.pdf




Radio: Can a choline deficiency contribute to fatty liver disease?

Does choline play the same role in fatty liver disease in humans? There are a few reasons to think it does. The most convincing of these is that it's been demonstrated in folks getting fed intravenously. The most interesting of these is the wide prevalence of a defect in the gene that allows us to synthesize phosphatidylcholine from the amino acid methionine. Its prevalence is high in the general population but almost complete among those with fatty liver.

The basic mechanisms of fatty liver in humans are the same as they are in animals. Humans with fatty liver disease have increased lipogenesis (synthesis of fat from carbohydrate) (1), increased circulation of fat released from adipose tissue (2), and decreased secretion of fat from the liver (3).

Although folks with fatty liver release more fatty acids from the fat tissue, the studies cited above show that their livers don't actually synthesize more fat from these fatty acids than the livers of healthy folks do. So those fatty acids may contribute to "lipotoxicity" -- and in fact the creation of triglycerides in the liver is in part probably an effort to protect against the toxicity of excess free fatty acids -- but it seems that the synthesis of fat from carbohydrate is more important than the release of fat from adipose stores.

Continue reading at....

Does Choline Deficiency Contribute to Fatty Liver in Humans
http://blog.cholesterol-and-health.com/2010/11/does-choline-deficiency-contribute-to.html

Radio: Please check out this diagram
http://www.nature.com/nrgastro/journal/v7/n12/fig_tab/nrgastro.2010.172_F1.html

Phosphatidylcholine / Lipid (fat) transport and metabolism

Fat and cholesterol consumed in the diet are transported to the liver by lipoproteins called chylomicrons. In the liver, fat and cholesterol are packaged into lipoproteins called very low density lipoproteins (VLDL) for transport through the blood to tissues that require them. Phosphatidylcholine is a required component of VLDL particles. Without adequate phosphatidylcholine, fat and cholesterol accumulate in the liver (see Deficiency).

Choline Linus Pauling Institute
http://lpi.oregonstate.edu/infocenter/othernuts/choline/

Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/
CFS-me-as-a-liver-issue
http://forums.phoenixrising.me/index.php?threads/cfs-me-as-a-liver-issue.18776/




Radio: Is there a silent liver disease connection?

Nonalcoholic steatohepatitis or NASH is a common, often “silent” liver disease. It resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. The major feature in NASH is fat in the liver, along with inflammation and damage. Most people with NASH feel well and are not aware that they have a liver problem. Nevertheless, NASH can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly.

See more at :
The Silent liver disease.
http://digestive.niddk.nih.gov/ddiseases/pubs/nash/

Radio: A bacterial overgrowth can also produce histamine, hydrogen sulfide, hydrogen peroxide, tryptophanase, d-lactic acid and endotoxins. This could be a possible contributing factor to the acquired mitochondrial disease and silent organ damage.




Fatty liver
http://en.wikipedia.org/wiki/Fatty_liver
Non-alcoholic Fatty Liver Disease
http://en.wikipedia.org/wiki/Non-alcoholic_fatty_liver_disease
Downregulation of Hepatic Glucose-6-Phosphatase-α in Patients With Hepatic Steatosis
http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.118/full
Detoxification (The Liver)
http://www.gilbertssyndrome.com/detoxification.php
How-I-Recovered-From-CFS-part 2
http://forums.phoenixrising.me/index.php?threads/how-i-recovered-from-cfs-part-2.28684/

 

[Radio]

Radio: (Warning COM +/+ mutation), HCL Betaine is a methyl donor.

How to figure out your Betaine HCL dose
Each person will have a specific supplementary HCL dosage. Unfortunately, there isn’t a special formula I can give you to figure it out. This is a case of trial and error until you get to the correct dosage. Failing to get to your correct dosage can remove the benefits of supplementing.

You must find the right dosage for you situation. If you fail to do the trial and error you’re wasting your time and money.

This is a very common problem we see with our readers. Remember, the stomach is purposely built to handle extreme acid environments. If your correct dosage is 2400mg and you’re only taking 1200mg, you’re not really doing your stomach any favors. You must follow the process below to figure it out the right dosage to get the maximum benefit.

1. Eat a meal that contains at least 15-20grams of protein (about 4-6ounces of meat).
2. Start by taking 1 pill (650mg of less) of Betaine HCL during the beginning of the meal
3. Finish the meal as normal and observe your body for any changes in feeling associated with the stomach and belly button area. Things to look for: heaviness, hotness, burning, or other GI distress.
4. Stay at this dosage of 1 pill for another day of meals with protein and if you don’t notice anything on the 3rd day, try 2 pills.
5. Stay there for another day and then try 3 pills.
6. Keep increasing the number of pills taken with each meal until you notice some GI discomfort described in step #3.
7. When this happens, you will know your ideal Betaine HCL dosage is 1 pill less. For example, if you felt the discomfort going from 5 pills to 6 pills, then 5 pills is your proper dosage for a normal meal.

A couple points to clarify:
If you eat a snack or a meal without much protein, you won’t need as much Betaine HCL (for a small snack like a piece of fruit you won’t need any at all)

When you experience the GI discomfort finding your correct dosage, you can mix ½ teaspoon of baking soda in 8oz of water and drink it to help lessen the pain.


I Need to Take How Many Betaine HCL Pills?
It’s very common for people to stop short of their needed Betaine HCL dosage. In fact, in the beginning I was nervous about taking 6 pills at a meal. But trust me. there is nothing to worry about. Dr. Wright reports that the common Betaine HCL dosage range in his clinical practice is 3,250-4,550mg per meal. That means there are also plenty of people who need above 5,000mg for an effective dosage.

Remember a normal functioning stomach is capable of producing and handling extreme acid ranges. If your dosage starts getting extremely high without any GI distress (step #3), you must use your GI symptoms as a guide instead. These including burping, bloating, farting, and stool consistency. Keep everything else the same in your diet as you wait for these indicators to change for the better. Just because you can take 20 pills, doesn’t mean you should. It could be that at 11 pills all of your problems disappear. For this group of people try to find the minimum dose needed to help your GI symptoms and for peat sakes go get more testing to figure out what is going on!

Best Betaine HCL Supplement brands
When choosing a Betaine HCL supplement it’s important to choose one that includes pepsin. It’s assumed by the medical research that when supplementing with HCL you need to supplement with pepsin. That is why most Betaine HCL supplements you’ll find include it and Dr. Wright recommends it.

I also try to look for a brand that has a minimal amount of additives in the pills. I like the following brands (which are all SCD legal):

- See more at: http://scdlifestyle.com/2012/03/how-to-supplement-with-betaine-hcl-for-low-stomach-acid/

4 Common Betaine HCl Mistakes
http://scdlifestyle.com/2013/10/4-common-betaine-hcl-mistakes/

The liver P450 detoxification system is a major source of free radicals

There are two stages to liver detox. Stage one is an oxidation reaction to make molecules a bit more active in order that stage two can take place, in which another molecule is stuck on. This tacking on allows the toxin to become less active and more water soluble so it can be excreted in urine. The tacking on could be of a sugar (glucuronidation), amino acid, glutathione, sulphate group and so on.

There are many possible ways the liver P450 cytochrome system could be overwhelmed.

1. Genetic: some people simply have genetically poor detox ability. One example of this, of course, is Gilbert's syndrome, where conjugation with glucuronide (stage 2 detox) is lacking. There are two steps to detoxification: the first is an oxidation reaction which may make some toxins more toxic! Many CFS sufferers have fast stage one and slow stage two metabolism, which means they have a P450 system which initially produces more rather than less toxic stress! So, for example, over 80% of Gilbert's sufferers complain of fatigue. One example is alcohol. This is metabolised initially into acetaldehyde, which is a nasty toxic compound responsible for hangovers! Alcohol intolerance is almost universal in CFS sufferers.
2. An acquired metabolic lesion as a result of nutritional deficiency. For example, many of these P450 cytochrome enzymes are highly dependent on metal co-factors such as zinc, magnesium, or selenium, B vitamins and essential fatty acids.
3. Toxins produced from normal metabolism e.g. detoxifying neurotransmitters, products from immune activity, breakdown products from damaged tissues etc
4. Overwhelming toxins from the outside world, such as persistent organic pollutants, or of course prescribed drug medication or social drugs of addiction (caffeine, alcohol). This is part of the explanation why so many CFSs do not tolerate prescription medication. Other reasons are that many drugs inhibit mitochondria directly, or destabilse membranes in the brain resulting in poor energy delivery to brain cells see Brain fog - poor memory, difficulty thinking clearly etc. Patients refusing medication then get labelled as unco-operative and are dropped from medical care.
5. Intoxicants arising as a result of fermentation from the upper gut.

Tests for liver detox ability
We can do a Detoxification Profile at Genova Diagnostics in the USA. This is a functional test to look at stage one and stage two detoxification.
Continue reading at...

Fermentation in the gut and CFS
http://www.drmyhill.co.uk/wiki/Fermentation_in_the_gut_and_CFS

Radio: Liver Testing info

Liver function tests
http://en.wikipedia.org/wiki/Liver_function_tests
Comprehensive Detoxification Profile
http://www.completehealthinstitute.com/SiteFiles/Laboratory_Test/gi_Detoxification_Profile.php
Detoxi-Genomic-Test-Description.pdf
http://www.gdx.net/core/one-page-test-descriptions/Detoxi-Genomic-Test-Description.pdf




Radio: Dysbiosis Links and Research

Bacterial, Fungal & Parasitic Overgrowth
http://www.medicalinsider.com/bacterial.html

Increased D-Lactic Acid Intestinal Bacteriain Patients with Chronic Fatigue Syndrome
http://www.cfids-cab.org/rc/Sheedy.pdf

d-Lactate in Human and Ruminant Metabolism
http://jn.nutrition.org/content/135/7/1619.full

Mycoplasma blood infection in chronic fatigueand fibromyalgia syndromes
www.cfids-cab.org/cfs-inform/Mycoplasma/endresen03.pdf

Hydrogen sulfide theory and gut dysbiosis:http://phoenixrising.me/wp-content/uploads/H2S1.pdf



Disclaimer
The information on this thread is not intended to be medical advice. The information is meant to inspire and motivate you to make your own decisions surrounding your health care and dietary needs. It is intended for educational and informational purposes only. You should not rely upon any information found on this thread to determine dietary changes, a medical diagnosis or course of treatment. Readers should perform their own research and make decisions in partnership with their own health care providers.

 

[Hip]

What the hell is this thread about? It seems like a more or less random collection of stuff about the liver that you have cut and pasted into this forum.

 

[Radio]

What the hell is this thread about? It seems like a more or less random collection of stuff about the liver that you have cut and pasted into this forum.

Hip, post: What the hell?

The Liver Connection

I should not even respond to your rude post. But, I will to help others understand. I am convinced that the toxic waste produced by the dysbiosis imbalance can be very damaging, especially when we are not methylating RNA, DNA and phosphatidylcholine. Also, manganese and zinc deficiencies can possibly cause a choline deficiency. Choline is essential for the health of the liver and mitochondria. There are many genetic variations that contribute to the liver detoxification capacity.


Sweet-truth-about-liver-and-egg-yolks
http://blog.cholesterol-and-health.com/2010/11/sweet-truth-about-liver-and-egg-yolks.html

 

[Hip]

It was not intend to be rude, but rather express my poor brain's general exhausted reaction to trying to grasp the meaning of reams of quoted text with no clear written guidance on why it is quoted.

People are not telepathic. It helps if you explain what you are trying to say, rather than assume the reader guess the context from the particular items you quote.

Remember, most people with ME/CFS have brain fog, and often find it hard to follow even clearly written text.

Two or three paragraphs of written text by you, clearly explaining what you are saying, are worth far more that these reams of quoted text, that many people with ME/CFS brain fog are not going to be able to follow or penetrate.

I have brain fog plus ADHD, making particularly hard for me to follow such volumes of information, when no guidance is given.

I am sure others here will also find it hard.


I should add that I know you are trying to help people, and this is appreciated.

 

[xchocoholic]

Hip summed up what I was thinking.

This thread needs a simple summary statement.

The part about h pylori in particular didn't seem to fit. I didn't get h pylori until a couple of years ago, labs prove this, but my liver has been challenged for longer.
I have / had dysbiosis.

Thanks for trying tho. X

 

[Sushi]

@Radio

Hi Radio,

I think this thread would be a lot clearer with proper attribution embedded in each quote. At the moment it is not clear what came from where.

Best,
Sushi

 

[Radio]

Hip summed up what I was thinking.

This thread needs a simple summary statement.

The part about h pylori in particular didn't seem to fit. I didn't get h pylori until a couple of years ago, labs prove this, but my liver has been challenged for longer.
I have / had dysbiosis.

Thanks for trying tho. X

Hey X,

I didn't get h pylori until a couple of years ago

Most people are infected with h pylori as a kid and up to 85% of people infected with H. pylori never experience symptoms. Please take some time and study Amy Yasko work on this subject.

Research
If you don’t know anything about h. pylori I suggest you watch these video’s. I have done lots of research over the past months and these videos are very detailed and explain the biochemical process your body goes through and what the h. pylori does (what vitamins it takes away, detox pathways it ruins, etc..) to the body. I wont lie- they are long, but if you are serious about eradicating the h.pylori for good, then you need to know your facts.

h. pylori- another piece to the puzzle

h. p- part 2

I find Dr. Amy is a very thorough Dr. and researcher and her protocol and testing techniques actually work. Here is her site.

- See more at: http://www.mygutsy.com/is-h-pylori-...drenal-fatigue/#sthash.1KzwEYym.M5KZKoFT.dpuf

Get the right H. pylori test
http://www.ulcer-cure.com/index.php/h-pylori/all-about-h-pylori/getting-an-accurate-h-pylori-test
See more about H-pylori info at, http://www.mygutsy.com/is-h-pylori-...sorders-adrenal-fatigue/#sthash.1KzwEYym.dpuf
Helicobacter Wiki
http://en.wikipedia.org/wiki/Helicobacter_pylori

 

[xchocoholic]

I had the Metametrix stool test before, during and after. These showed 0, mega, and gone. My integrative doctor is very thorough.

Sometimes when you're making a point, less info is better. Fwiw, I used to post threads like this too when I was brainstorming. My original thread on OI in 2007? probably drove people crazy.


Tc ... x

 

[Undisclosed]

@Radio I do agree that these posts are very difficult to read and hard to follow. It would be nice to have a brief synopsis in your own words with a few links to relevant articles. I think a few members here have posted this and it appears to be very frustrating for some. Short and sweet is really helpful.

I understand liver problems/gut issues etc but I am not sure how it all ties in to ME. I have worked with quite a few patients in my time with various stages of liver disease that resulted in quite serious fatigue but not what you would call ME -- eg., absence of PEM/PENE, no sleep issues and recovery after treatment. Liver disease is clearly a distinct diagnosis. Both my liver and gut are fine, yet I remain ill. I cleared up my gut issues on my own through trial and error, I was so hoping I would feel significantly better - but no. I am not sure if you are saying liver dysfunction and dysbiosis cause ME or contribute to making it worse. Clear as mud. It's all very complicated and I am pretty sure if you have liver disease, gut issues etc, they might radically exacerbate ME symptoms.

 

[Sushi]

@Radio

....
Sometimes when you're making a point, less info is better. Fwiw, I used to post threads like this too when I was brainstorming. My original thread on OI in 2007? probably drove people crazy.

Tc ... x

Agree, less is more when you are posting for brain-fogged members.

Sushi

 

[Radio]

@Radio


Agree, less is more when you are posting for brain-fogged members.

Sushi

I've had brain fog for many years before I changed my diet and balanced my gut dysfunction. I do understand what it feels like to have these limitations. I will try and keep my threads more on point.

 

[Radio]

7 Foods to Maximize Liver Health & Function

 

[Radio]

@Radio I do agree that these posts are very difficult to read and hard to follow. It would be nice to have a brief synopsis in your own words with a few links to relevant articles. I think a few members here have posted this and it appears to be very frustrating for some. Short and sweet is really helpful.

I understand liver problems/gut issues etc but I am not sure how it all ties in to ME. I have worked with quite a few patients in my time with various stages of liver disease that resulted in quite serious fatigue but not what you would call ME -- eg., absence of PEM/PENE, no sleep issues and recovery after treatment. Liver disease is clearly a distinct diagnosis. Both my liver and gut are fine, yet I remain ill. I cleared up my gut issues on my own through trial and error, I was so hoping I would feel significantly better - but no. I am not sure if you are saying liver dysfunction and dysbiosis cause ME or contribute to making it worse. Clear as mud. It's all very complicated and I am pretty sure if you have liver disease, gut issues etc, they might radically exacerbate ME symptoms.

Kina: I cleared up my gut issues on my own through trial and error, I was so hoping I would feel significantly better - but no.

The 7 Keys To My Recovery

1. Functional Medicine Practitioner (Laboratory Testing / Protocol Support)

2. Modified Paleo Diet + (Glycogen Supportive Foods) + (Beneficial Fermented Substrates)

3. Balance gut organisms (H-pylori / Dysbiosis Support) + (HCL / Digestive Aid)

4. Mitochondria Support (Lipid Replacement Therapy) + (CoQ-10 Ubiquinol / Vitamin E Support)

5. Methylation / Mineral Support (Fred Davis' protocol) + (SAMe / Vitamin D Support)

6. Liver Detoxification / PST Sulfation / Sulfate Support) + (Comprehensive Liver Testing)

7. Spiritual Support


Radio Note: I wanted to add that this is a simplified assessment of the road to my recovery. I know there will be subgroup who will need extensive testing and treatment of chronic infections and environmental toxins. My mitochondria trigger was combination of a toxic exposure and physical exertion that develop into CFS. Also, Hereditary hemochromatosis, also known as iron overload disease needs to be tested for as well.

Please see more at:
http://forums.phoenixrising.me/index.php?threads/how-i-recovered-from-cfs-part-2.28684/


Radio: Please watch these videos on gut dysfunction and dysbiosis. Also, I have restructured my thread to make it easier for forum members to understand this connection.

Radio: Please research Dr. Alex Vasquez per-review work on dysbiosis, inflammation and chronic health problems.


Alex Vasquez, D.C., N.D.
http://www.academia.edu/3862817/Nut...etal_Inflammation_and_Chronic_Health_Problems

 

[Radio]

Hypochlorhydria
A significant consequence of atrophic gastritis is hypochlorhydria and achlorhyria, which in turn may have the following effects on physiology (Howden & Hunt, 1987; Modlin et al., 1994):
1) Increased microbial enteric infections and small intestinal bacterial overgrowth
2) Increase in intestinal permeability resulting from malabsorption and/or bacterial overgrowth or alteration of gastric mucosa architecture as a result of low acidity levels
3) Nutrient malabsorption.

Intestinal Infection
It is well recognized that reduction in stomach acidity increases risk of infection by Salmonella, Shigella, E. coli, Vibrio cholerae and the protozoan Giardia (Howden & Hunt, 1987). In developed nations where hygiene standards and microbial water quality is high, this may be a relatively insignificant problem. However, in developing nations, this is often not the case and increasing levels of achlorhydria is seen as being a major contributor to the levels of enteric infection and diarrhea (Howden & Hunt, 1987).

Similarly, it is known from animal experiments that low acid production increases susceptibility to nematode and helminthes infections. This is unlikely to be different for humans and may be one of the contributing factors to the enormous prevalence of parasitic infections in both developed and developing countries.

Small Intestine Bacterial Overgrowth
Overgrowth of bacteria in the stomach, duodenum and jejunum is commonly associated with hypochlorhydria, especially if chronically associated with atrophic gastritis. The overgrowth organisms are typically Staphylococci, Streptococci, Enterococci, and Candida and they probably originate from oral source rather than "growback" from the ileum and large intestine. The normal fragile flora of Lactobacilli typically found in the healthy small intestine appears to be overwhelmed (Husebye et al., 1992). Because these organisms are considered commensals, acute adverse effects from their overgrowth are rare. However, the overgrowth of potentially antibiotic resistant Staphylococci and Enterococci is never desirable, and may have marked adverse effects in the immunocompromised or those intending to have intestinal surgery.

In addition to this, there is a growing body of opinion and data that suggests that dysbiosis in the intestine can be responsible for, or be a significant contributor to, irritable bowel syndrome, chronic fatigue syndrome, arthralgias and depression (Madden & Hunter, 2002).

Long-term chronic sequelae to bacterial overgrowth are likely to become more recognized as studies accumulate, and indeed our own research group found in open human invasive trials that mucosal colonization by Candida albicans and other yeasts is very common whenever intestinal overgrowth with these fungi occurs (Madden et al. — in press). The importance of the mucosal colonization by the yeast was that it triggered a change in morphology from the single cell to hyphal form of the yeast. This in turn elicits an inflammatory response in the mucosa, which if not resolved could give rise to a chronic inflammatory condition.

The Unseen Epidemic: The Linked Syndromes of Achlorhydria and Atrophic Gastritis
http://www.townsendletter.com/July2004/unseenepidemic0704.htm

Niacin (Nicotinic Acid) a PutativeTreatmentfor Hypochlorhydria: Re-analysis of Two Case Reports http://orthomolecular.org/library/jom/2002/pdf/2002-v17n03-p163.pdf



The Invisible Universe Of The Human Microbiome ~ Ben Arthur

Gut bugs misbehaving? http://phoenixrising.me/archives/20926

 

[Radio]

H.pylori-Hypochlorhydria-Dysbiosis-Liver-CFS/ME Connection?


I believe we have genetic factors as well as environmental issues that make us vulnerable to this illness. The root cause of this conundrum in my opinion is inflammation of the stomach lining that develops into hypochlorhydria, depleting the stomach ability to produce hydrochloric acid. HCL insufficiency could be the main contributing factor to the bacteria over-growth problem. We need the correct gut pH to balance and maintain intestinal flora. I am now advocating that everyone in this forum be tested for Autoimmune Atrophic Gastritis. The Antiparietal and anti-IF antibodies test is a simple easy blood test you can have done by your primary care physician. I'm also recommending the Endoscopy procedure for people with a history of H.pylori infection and hypothyroidism. We need to challenge ourselves and ask the right questions in order to have a better understanding of the root cause of this Acquired Mitochondrial Disease.



Radio: What is Atrophic Gastritis?

Atrophic gastritis (AG) is a condition that develops when the stomach’s lining has been inflamed for many years. The inflammation is most often caused by an infection of the bacterium H. pylori. The infection gradually destroys cells in your stomach lining. It is thought that the bacteria cause inflammation by disrupting the barrier of mucus that protects your stomach lining from the acidic juices that help it digest food. Less often, AG occurs because your immune system mistakenly attacks the cells in your stomach lining. This is known as autoimmune atrophic gastritis. See more at: http://www.healthline.com/health/atrophic-gastritis#Description

Radio: How can we test for gastritis?

Using a scope to examine your upper digestive system (endoscopy). During endoscopy, your doctor passes a hollow tube equipped with a lens (endoscope) down your throat and into your esophagus, stomach and small intestine. Using the endoscope, your doctor looks for signs of inflammation. If a suspicious area is found, your doctor may remove small tissue samples (biopsy) for laboratory examination. See more at: http://www.mayoclinic.org/diseases-conditions/gastritis/basics/tests-diagnosis/con-20021032

Ways to test if you have low stomach acid (even though it’s a given for most thyroid patients if you find yourself with low nutrients like iron, B12, Vit. D or more)

1. Baking Soda test (non-scientific): After you have gotten up in the morning, and before eating or drinking, mix about 1/4 tsp baking soda in a cup of water and drink it down. Watch to see if you have burped in the next 2 – 3 minutes (stomach acid and baking soda react to form carbon dioxide gas). If you do NOT, you probably have low stomach acid. NOTE: one test is not definitive. You have to do this test at least 3 mornings and see if you have more “No, I didn’t burp in 2-3 minutes”, then Yes, I did. This test is only a rough indication.
2. Betaine HCl Challenge Test (non-scientific and not to be done if you have peptic ulcers): You will need to purchase Betaine, preferably the 600 mg pills, at your local health food store–a man-made hydrochloric acid. Your goal is to find out how many tablets it takes to feel a warmth or burning in your stomach. Patients with normal stomach acid levels would feel this with one, or sometimes two pills. On the first day, take one right before or at the beginning of large meal. On the second day, take two before or at the beginning of a large meal. On the third day, take three before or at the beginning of a large meal….etc up to the 7th day and 7 tablets, if needed (some versions of this test go up to ten days and 10 tablets). The more tablets you have to take to feel that warmth, the more likely you have low stomach acid. NOTE: if this test produces excess burning in the beginning, it’s a sign you have too much stomach acid and this test should immediately stop. Otherwise, this test is only meant to be used until you feel that burn/warmth, which could happen before the seventh day.
3. The Heidelberg Stomach Acid test (scientific): This is a test you’ll have to ask your doctor about, and thus, is far more exact than the above, but can be costly–more than $300 US. You are instructed to drink a baking soda solution (sodium bicarbonate) as well as swallow a capsule with a tiny pH meter and radio transmitter (radiotelemetry). It will analyze the pH of your stomach acid. NOTE: you will need to be off any Proton Pump Inhibitors or over-the-counter stomach aides for about five days. This test takes about an hour or slightly more time.See more at: http://www.stopthethyroidmadness.com/stomach-acid/

Hypochlorhydria + Dysbiosis + Chronic inflammation = Acquired Mitochondrial Disease

 

[Radio]

Radio: How to we treat Gastritis?

Home remedies Gastritis #2: Drink eight large glasses of water a day.
Home remedies Gastritis #3: Take 400 IU a day of vitamin E to reduce inflammation in the stomach.

Home remedies Gastritis #4: If your gastritis is caused by anemia, take supplemental chlorophyll two capsules three times a day, and follow the recommendations under anemia.

Home remedies Gastritis #5:Licorice (DGL) helps heal the gastrointestinal tract chew 300 to 600 mg. 30 minutes before meals. This herb is also use to treat ulcers. Licorice is as effective as Tagamet.

Home remedies Gastritis #6: Take Artichoke if you feel abdominal pain, bloating or to relive vomiting, and nausea.

Home remedies Gastritis #7: One of the best herbs for treating gastritis is Ginger it relives almost all symptoms including indigestion and gas, quickly healing stomach and intestinal tissue, reduces inflammation, and ulcerated linings. Ginger is an anti-inflammatory and antibacterial. It reduces nausea, stimulates digestion of fats and it’s a natural antibiotic.

Home remedies Gastritis #8:Goldenseal destroys bacteria that causes gastritis, stomach inflammation and ulcers.

Home remedies Gastritis #9:Marshmallow relives nausea, indigestion, gastritis and ulcers.

Home remedies Gastritis #10:Peppermint contains volatile oils like menthol, relives indigestion, gastritis and stomach ulcers.

Home remedies Gastritis #11:Papaya seeds and pineapple aid digestion. It should be eating slightly ripe. Papaya is rich in digestive enzymes. See more at: http://www.homemademedicine.com/home-remedies-gastritis.html

Natural remedies for gastritis

• The amino acid Glutamine helps with maintenance of gut barrier function. Glutamine powder (available in health food stores) can be taken daily to improve the integrity of the stomach lining. Mix the following ingredients together and take before meals - glutamine powder, slippery elm, acidophilis powder, Aloe Vera juice and liquid Zinc. The combination of these ingredients can be taken daily to improve the integrity of the stomach lining and help it to heal
• Slippery elm powder has a regenerating effect on the lining of the stomach, it provides a barrier between the mucus membranes and the digestive acids so that healing can take place
• Herbs which may be of assistance to soothe and help dowse the fire of this inflammatory condition are Chamomile, Marshmallow, Licorice, Green Tea, Cats Claw, Pinellia and Coptis Root. In Chinese medicine inflammatory digestive problems arise from excessive heat/ fire which needs to be neutralised.
• B Vitamins (specifically B12) may help to heal the mucosa
• Aloe vera juice – taken regularly may help to reduce inflammation
• Vitamin C may help to prevent and treat gastritis (due to its ability to suppress Helicobacter pylori)
• Zinc is an important mineral for healing and is a common nutrient deficiency
• Take a probiotic supplement to encourage a healthy balance of good digestive flora and to address Helicobacter pylori or Candida infection and reduce fermentation of foods.

• Increase your consumption of soothing (demulcent) foods such as papaya and banana
• Reduce acidic foods which contribute to inflammation such as tea, coffee, alcohol, soft drinks, dairy, wheat, sugar, refined and processed foods
• Increase alkalising foods such as miso soup, vegetable juices, lemon juice, green leafy vegetables, sprouts, fish, water and herbal teas
• Increase Glutamine containing foods- cabbage, papaya, celery, spinach, dandelion greens, lettuce, parsley, cabbage, brussel sprouts and carrots
• Don’t drink large amounts of liquids 20 minutes prior to eating or after eating as it will dilute the digestive enzymes and reduce digestive function further
• Don’t eat large amounts of food at each meal, stick to eating smaller meals more often during the day. If you have limited amounts of digestive enzymes then large meals will greatly increase bloating
• Introduce herbal teas into your diet such as Peppermint, Ginger, Licorice, Fennel and Chamomile to support digestion and reduce symptoms of digestive discomfort
• Increase your consumption of good oils in the diet to lubricate the lining, reduce inflammation and promote healing. Good oils include raw unheated olive oil (added to salads or meals before serving), flax seed oil, avocados, nuts and seeds and fish oil
• Dont eat at times when you are feeling stressed
• Start each day with a small glass of warm water with ½ lemon squeezed in it. Lemon juice increases digestive juices, cleanses the bowels and kick starts the liver to detoxify
• Make a vegetable juice each day to help alkalise the system and add cabbage juice to it because cabbage contains Substance U which may help to alleviate gastritis and reduce pre-ulcer formation
• Use Manuka Honey in a warm lemon and ginger drink to help soothe the digestive tract. Manuka honey contains potent anti-microbial and soothing effects to the stomach. See more at: http://www.askanaturopath.com/faqs/gastritis/p/697

Radio: Note We need to identify and treat H-pylori and gastritis first, before we can implement HCL therapy. COMT +/+ could benefit from bitters, enzymes and other beneficial natural strategies.

 

[Radio]

Bile acids are also important contributing factor in maintaining the correct gut pH balance and controlling the intestinal flora over-growth. Cholesterol is also needed in bile acid production. My new research is pointing to problems with cholesterol / bile metabolism as a possible key missing co-factor in the progression of chronic disease.

Bile emulsifies fat, increasing fat absorption. Bile also contains the conjugated toxins from the 2 phases of liver detoxification. These toxins may include carcinogens, xenobiotic chemicals, pharmaceuticals and heavy metals like mercury, aluminum and lead. When hemoglobin is broken down in the liver, bilirubin is conjugated and excreted through the bile.
Inadequate levels of bile can cause a build-up of toxins in the liver because of the fact that bile conjugates and carries out the body’s burden of toxicity. Liver congestion can result in gall bladder stones and stagnation. If a person’s cholesterol production is low, bile production is also likely to be low.
On a blood test, if blood cholesterol levels are lower than 170, it is possible there is a bile acid insufficiency. Increases or decreases in the liver enzymes ALT (>30, <10) or AST (>30, <10), GGTP (>30) can indicate dysfunction and/or congestion in the liver. See more at: http://metabolichealing.com/bile-deficiency-heartburn-poor-digestion-toxicity/

In the absence of Bile, bacteria and other microbes such as yeasts and fungi are able to flourish. Bile has a Bactericidal effect which helps to keep the small intestine somewhat sanitized.

The viable counts in cultures containing taurocholate
showed almost complete death after 24 hours, whereas the
viability of the organisms in taurocholate-free cultures at that
stage was 100%. See more at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1786299/?page=2

Bile acid / Wiki
http://en.wikipedia.org/wiki/Bile_acid


Disclaimer
The information on this thread is not intended to be medical advice. The information is meant to inspire and motivate you to make your own decisions surrounding your health care and dietary needs. It is intended for educational and informational purposes only. You should not rely upon any information found on this thread to determine dietary changes, a medical diagnosis or course of treatment. Readers should perform their own research and make decisions in partnership with their own health care providers.

 

[Radio]

Radio: The next step in my recovery was: Mitochondria Support (Lipid Replacement Therapy) + (CoQ-10 Ubiquinol / Vitamin E Support)


Lipid replacement therapy can potentially help everyone in this forum. It does not matter which subgroup of CFS/ME you are in. The core of the problem has always been acquired mitochondrial damage. Repairing the Mitochondrial is the first step in healing. This is one of the missing links in the chain to recovery. At this point, the fact is, we need mitochondrial support. The main focus is to prevent Apoptosis cell death and it's imperative that we start mitochondria supportive therapy at the on set of CFS/ME.


The Mitochondria can becomes damaged and leaky from an overload of metabolic waste. Phospholipids and glycolipids can repair cellular membranes by increasing cell membrane fluidity. By repairing these membranes we allow our cells to increase their nutrient uptake so that the mitochondria may product more ATP.


Acquired mitochondrial damage is a normal part of aging, but is accelerated in chronic fatigue syndrome and many other metabolic disorders. We must address this before complete healing can be initiated. Phospholipids replacement therapy and eating a super clean diet is the first critical steps in repairing this damage. Chronic deficiencies and methylation factors as well as gut imbalances destroys the mitochondrial membranes and lead to the modern day diseases we see today.



Radio: This concludes my broadcast for now Pay it forward and never give up!



See more at:
Reverse-Mitochondrial-Damage-101
http://forums.phoenixrising.me/index.php?threads/reverse-mitochondrial-dama

 

[Antares in NYC]

Well, on top of the ME/CFS, the Lyme, the off-the-charts EBV titres, and the MTHFR mutation, and after years of testing severely deficient on B-12, I just tested positive for anti-parietal cell antibodies which means possible pernicious anemia.

Now what?

I'm really worried. I feel my health continues on a free-fall, no matter what I do.