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Wendi C: I'm no expert but a few things jump out at me.
The three week mark was where I got really sick when beginning methylation/Freddd's protocol. I had to increase my folate significantly. Research "paradoxical folate deficiency" and "donut hole" on this forum and see if maybe increasing your folate is a step you want to take. It worked for me. I'm still having some minor symptoms but I've been pretty messed up for at least a couple of decades so am willing to give healing some time to work through. However, I do agree with @
Critterina that you need to evaluate if you want to do that. "Powering through" is a personal decision and may not work for everyone.
If you up your folate you probably also would want to increase your mB12, like doing sublingual lozenges at different times of the day. My understanding is that methylcobalamin clears the body fairly quickly, even sub-q. And a half ml isn't that much. It's over standard recs for mainstream medicine, but that doesn't signify much of anything. I do sub-q 1.5ml in the morning and then supplement a couple of times per day with at least 4000mcg sublingual each time, hold them between teeth and gums for at least an hour. Holding the lozenges is not as hard as it sound and it seems to be necessary to infuse a beneficial amount through the tissues.
Read this thread posted yesterday by @
stridor about amounts of mB12 and healing on Freddd's protocol in general
http://forums.phoenixrising.me/index.php?threads/ok-this-is-weird-mb12.28753/
Worth noting is I had a bad reaction to SAM-e years ago, too, when it first became the rage. I was reluctant to add it to my current methylation regimen because of that bad experience. But I tried it about a week ago and it seems to have a bit of a beneficial effect. Certainly hasn't detracted from anything. I'm on low dose (200mg/day) . I'm thinking now that my bad reaction was because I wasn't taking all the necessary cofactors needed make it work properly. Perhaps that was the source of your bad reaction, too. I wouldn't advise adding it in now, because if you're going to add anything you probably need more methylfolate and mB12 until you get leveled out, but you might consider it for the future.
Also, I don't know much about how to read the genetics, as I've never been tested. But I do know that some people can't use folinic acid. Is there a particular reason you're taking additional folinic acid and not just straight methylfolate? From what I understand there's no downside to using methylfolate by itself even if you can process folinic acid and folic acid properly...but if you take folinic or folic acid and you *can't* process them properly, it can interfere with your body's ability to use the methylfolate. Make sense? So if your body can't use folinic acid it could be blocking the action of the methylfolate you're already taking. Again, read about the donut hole and paradoxical methylfolate deficiency.
Finally, regardless of methylation, 100mg/day is A LOT of zinc. That much zinc can cause problems, especially without adequate bioavailable copper to balance it. Did your doctor advise you to take that much? I've never heard of a rec to take that much zinc, ever and I've been learning about and fiddling with supplements for several decades,. About 60mg/day for a very short time is about as much as I've ever heard anyone recommend anywhere, anytime, for anything, unless actively chelating. Unless you're doing this for a specific purpose and have been advised by your doctor, I strongly suggest reducing the amount of zinc you take by at least half.
Hope that gives you a little to think about.
P.S. I received TMG today so will let you know if I get any good or bad effects from it.
