Hi @
anniekim ,
I don't think that the COMT + status means all things methyl, and not all COMT + people have trouble with methyl donors.
Your ++ (homozygous) VDR Taq suggests that you should keep your vitamin D levels up, probably in the upper half of the normal range, because your receptor sites aren't as good at binding as VDR Taq negative people. You will need blood tests to verify that you're at a good level.
The BHMT 08 ++ means your secondary methyl pathway is inefficient; it could be helped by TMG, but that is tri-methyl-glycine. It's normally written without the hyphens, but I wanted to emphasize that it has three methyl groups - not a good place to start if you may be sensitive to them! So let's forget about that for now.
You have MTR A2756G, which means you are more efficient at using up methylfolate for the primary pathway of the methyl cycle (also meaning that you're probably OK ignoring your BHMT mutation in your secondary pathway.) There's nothing wrong with that. But, you have MTHFR A1298C, which means you're not so efficient at using methylfolate for the biopterin cycle. So most of your methylfolate gets used for one thing and not another.
The biopterin cycle makes neurotransmitters serotonin and dopamine, which then turn into other important things. A lot of symptoms and conditions are identified with lower biopterin function: migraines, anxiety, depression, autism, bipolar, fibromyalgia, chronic fatigue, Parkinson's, irritable bowel, ADHD, etc. If you have absolutely no problems with these, you're lucky. If you want to supplement, use methylfolate. Many people on this site like Solgar brand.
Start with a small amount if your sensitive to supplements - some people just crush up a tablet and put a little powder on their tongue. Then if you're OK, a little more. Me, I just took the whole pill and had no ill effects. You need to learn enough to choose for yourself. Hope that what I've said gives you a start on what to look into.
I'm not sure, but I think that COMT individuals who react to methyl donors react to methylcobalamin (b12), TMG, SAMe, and others, but not methylfolate.
One thing for consideration further down the road, is that if you find a methylfolate dose that is good for you, you might - well, you might leave well enough alone, but you also might consider trying folinic acid instead (folinic, not folic acid). You should have no trouble converting folinic to methylfolate, so in theory, it should be about the same. The main reason for the switch is that folinic acid is quite a bit cheaper. I don't remember the price difference, but it may be $15-$20/month if you take 1 mg/day. Please let me know if you decide to do this and whether it works. I'm going to try it myself, but I'm not out of methylfolate yet.
Good luck.