Bob
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I don't think this has been posted yet.
Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function.
Garth L. Nicolson, Robert Settineri and Rita R. Ellithorpe
Functional Foods in Health and Disease 2014; 4(1):23-65
Publication date: January 25, 2014
Full paper available here:
http://functionalfoodscenter.net/files/81845995.pdf
This paper is a review of various studies that have tested health supplements for a variety of fatiguing illnesses, including CFS.
There are a grand total of 319 references in this paper! A special Phoenix Rising prize goes to the first person who reads them all!
The review suggests that there have been substantial reductions in fatigue in CFS patients after some of these supplements were prescribed. But the devil is in the detail i.e. the methodology of the reviewed papers. i.e. were there control groups?
I've only checked one of the reviewed papers (see next post), which does not have a control group, but I suspect that they are mostly, or entirely, low-powered and without an adequate control group.
Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function.
Garth L. Nicolson, Robert Settineri and Rita R. Ellithorpe
Functional Foods in Health and Disease 2014; 4(1):23-65
Publication date: January 25, 2014
Full paper available here:
http://functionalfoodscenter.net/files/81845995.pdf
This paper is a review of various studies that have tested health supplements for a variety of fatiguing illnesses, including CFS.
There are a grand total of 319 references in this paper! A special Phoenix Rising prize goes to the first person who reads them all!
The review suggests that there have been substantial reductions in fatigue in CFS patients after some of these supplements were prescribed. But the devil is in the detail i.e. the methodology of the reviewed papers. i.e. were there control groups?
I've only checked one of the reviewed papers (see next post), which does not have a control group, but I suspect that they are mostly, or entirely, low-powered and without an adequate control group.
ABSTRACT
Background: Many chronic diseases and illnesses are associated with one or more chronic
infections, dysfunction of mitochondria and reduced production of ATP. This results in fatigue
and other symptoms that occur in most if not all chronic conditions and diseases.
Methods: This is a review of the published literature on chronic infections in neurodegenerative
diseases and fatiguing illnesses that are also typified by mitochondrial dysfunction. This
contribution also reviews the use of natural supplements to enhance mitochondrial function and
reduce the effects of chronic infections to improve overall function in various chronic illnesses.
Results: Mitochondrial function can be enhanced by the use of various natural supplements,
notably Lipid Replacement Therapy (LRT) using glyerolphospholipids and other mitochondrial
supplements. In various chronic illnesses that are characterized by the presence of chronic
infections, such as intracellular bacteria (Mycoplasma, Borrelia, Chlamydia and other infections)
and viruses, LRT has proven useful in multiple clinical trials. For example, in clinical studies on
chronic fatigue syndrome, fibromyalgia syndrome and other chronic fatiguing illnesses where a
large majority of patients have chronic infections, LRT significantly reduced fatigue by 35-43%
in different clinical trials and increased mitochondrial function. In clinical trials on patients with
multiple intracellular bacterial infections and intractable fatigue LRT plus other mitochondrial
supplements significantly decreased fatigue and improved mood and cognition.
Conclusions: LRT formulations designed to improve mitochondrial function appear to be useful
as non-toxic dietary supplements for reducing fatigue and restoring mitochondrial and other
cellular membrane functions in patients with chronic illnesses and multiple chronic infections.
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