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Freddd --> is it possible you have confused mcg with mg? 90-120mg of B12? That would be a dose for King Kong
The Enzymatic + Anabol alone make 20-40mg, which is huge. I've probaby asked you this before. Can the body absorb all that much in a day?
Hi PeterPoitive,
As it is taken through oral mucosa absorption, and I have experimented with multiple ways, the actual absorbed dose is about 1/4 to 1/3 of that. I take it as 3 2-3 hour doses. It is equivalent to 3x10mg subcutaneous injections, which currently around here cost $1000/month or more. I can do it through mucosal absorption for $300+/month. Yes, it gets absorbed and into the cerebral spinal fluid in sufficient amount for healing. Everybody I know who has had success at putting SACD in remission and even back it up considerably uses doses of this size. There is a small group trialing 500mg to1000mg a day. This is based on the Japanese trials that set the dose at 50mg/day for CNS penetration and they used a variety of methods. They also did intrathecal injections of 2.5mg MeCbl. It lasted in people from under 3 months to over 4 years so far. The benefits last as long as the amount remains high. Quite a variety of studies have shown that people with CFS, FMS, ALS, MS, Parkinson's, Supra Nuclear Palsy, Autism, Alzheimer's and probably others have low CSF cobalamin levels independent of body level. Further those diseases also typically have high CSF Hcy and/or high CSF MMA indicating breakdown in methylation and/or mitochondrial ATP formation to an extreme amount. Further there is documented neurological damage for instance in various parts of the brains and cord depending upon the specific diseases in many cases.
Safety studies have been done to much higher levels in uremics who accumulate b12. The dose for correcting cyanide poisoning is multiple 35 gram (35,000,000mcg) infusions of HyCbl, AdoCbl or MeCbl. Because of shelf life they tend to use HyCbl as it is already "broken down" from the more active forms and can be left in a non-opaque IV bottle without further photolytic breakdown.
In my own series of injection trials from 1mg to 60mg per injection, 3 times per day. I mapped where the amount becomes visible in the urine and how much so under various conditions of Methylfolate sufficiency, folic acid partial methylation block, folinic acid partial methylation block, low dose methylfolate with donut hole insufficiency and glutathione induced methyltrap. Some others replicated various parts of this and one man did infusions to 500mg.
Further I found the CNS effectiveness starts in me at >6mg and <7.5mg. CNS effectiveness in me and some others requires 4x7.5mg SC injections daily, 3x10mg SC injections daily or 2x15mg SC injections daily (some, not everybody). The number we keep coming up with is 30mg distributed across the day to keep continuous CNS effectiveness going without daily fallback.
I'm no King Kong, I've shrunk from 6'1" to 5'11" (disks etc) in the past 20 years, and weigh 185 in summer and about 200 winter when I get less exercise. Body size did not appear to make any real difference nor did gender in all this.
And significant parts of my body are neuropathic slick so I can't even begin to match King Kong's hair. I can't even be a respectable hippy these days.