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I’ll start from the beginning. I am 35 and have had ocd/anxiety/depression my whole life. I can remember being a child and having those problems. Years ago I tried a ton of SSRI’s and therapy and they didn’t really help. I started experiencing fatigue to the point that I was falling asleep at stop lights so I got off the meds and took Metametrix Cardio Ion and later had saw Dr Calapai who did 20 pages of bloodwork. I have corrected a bunch of deficiencies and feel much better overall. The only thing that I still have is the Ocd/anxiety/depression.
In the last few months I have started getting panic attacks and crying for “no reason”. I decided to see a Psychiatrist who tried to put me on Pristiq/Deplin. I really didn’t want to go down that road again and opted not to take the Pristiq. I researched and started taking the Deplin 15mg for a couple weeks. In researching it, I found heard mthfr mutation mentioned. I remembered seeing that in my bloodwork. I read about methyl trapping/overmethylation and stopped the Deplin (although I wasn’t experiencing any adverse effects).
I am positive for 2 copies of the a1298c mutation. Homozygous for a1298c mutation and negative (normal) for the c677t mutation in the mthfr gene.
I spoke with someone very knowledgable on PhoenixRising and he helped steer me in the right direction with some things. I ordered a 23andme and just sent it off. It will be six weeks until I see the results. I live in NY which complicates things a bit. I had it mailed to me in NY and drove to CT to do the sample and mail it (20 minutes from my work).
I saw Dr Skowron http://www.naturopathicanswer.com/condi ... c-anxiety/ in CT. He looked at my 50 plus pages of bloodwork and recommeneded the following:
1)1500 mg GABA twice a day
2)Lavender 80mg twice a day
3)B complex http://www.metabolicmaintenance.com/pro ... s_minerals
With methylcobalamin 1000mcg and (6s)-5-methylfolate 800 mcg
4)Since I already have the Deplin, he asked me to cut into quarters and take 3.75mg a day.
The b12 is not a shot or sublingual. I do have shots at home but was urged to wait on those.
I have become more anxiouis on the GABA and he asked me to discontinue it. Hard to determine if it was the GABA or external events. I have heard that GABA doesn’t cross the Brain Blood Barrier.
My concerns are the following:
I am very concerned about methyl trapping/ overmethylation/ feeling worse. Is this course of action ok until I get the 23and me back? I have heard that a COMT mutation could give me problems if I start on that routine. I don’t know if that amount of L-5-methf in relation to b12 is a concern. I do have aluminum show up in my blood tests.
Some have said just to keep niacin on hand in case I run into problems. I want to be as proactive as I can be while still being safe and not causing any other problems.
Is there anyway to test for the other SNPS (COMT, CBS etc) that is quicker than the 6 weeks that 23andme will take? I do live in NYS, so I know that makes things tricky (worst state for this kind of stuff). Should I do a urine provoked metals test?
I could share/post/send (how?) my bloodwork if anyone wants to see it. Is there any way to maybe illuminate whether or not I MAY have COMT from anything else in my bloodwork? Does the fact that I was taking 15mg of Deplin every day for 2 weeks mean anything? I was taking shots of B12 at one point too…
I am also seeing things online about Dr Yasko and getting the BHMT pathway moving first. This is very confusing. There is talk of getting Lithium in balance and other things. This is very confusing.
Any thought anyone can give me on my suggested regimine
Or
How I should proceed
Or
A quicker test available in NYS for those SNPS other than MTHFR
Again, I have a TON of bloodwork (neurotransmitters, homocysteine, methionine etc) that I’d be willing to send.
I am going to attempt to attach it to this post but it might be too large. I was doing some supplementing so it is reflected in the testing. It is a large pdf - 50 or so pages and it wouldn't attach - let me know if you need to see it.
Thank you in advance
In the last few months I have started getting panic attacks and crying for “no reason”. I decided to see a Psychiatrist who tried to put me on Pristiq/Deplin. I really didn’t want to go down that road again and opted not to take the Pristiq. I researched and started taking the Deplin 15mg for a couple weeks. In researching it, I found heard mthfr mutation mentioned. I remembered seeing that in my bloodwork. I read about methyl trapping/overmethylation and stopped the Deplin (although I wasn’t experiencing any adverse effects).
I am positive for 2 copies of the a1298c mutation. Homozygous for a1298c mutation and negative (normal) for the c677t mutation in the mthfr gene.
I spoke with someone very knowledgable on PhoenixRising and he helped steer me in the right direction with some things. I ordered a 23andme and just sent it off. It will be six weeks until I see the results. I live in NY which complicates things a bit. I had it mailed to me in NY and drove to CT to do the sample and mail it (20 minutes from my work).
I saw Dr Skowron http://www.naturopathicanswer.com/condi ... c-anxiety/ in CT. He looked at my 50 plus pages of bloodwork and recommeneded the following:
1)1500 mg GABA twice a day
2)Lavender 80mg twice a day
3)B complex http://www.metabolicmaintenance.com/pro ... s_minerals
With methylcobalamin 1000mcg and (6s)-5-methylfolate 800 mcg
4)Since I already have the Deplin, he asked me to cut into quarters and take 3.75mg a day.
The b12 is not a shot or sublingual. I do have shots at home but was urged to wait on those.
I have become more anxiouis on the GABA and he asked me to discontinue it. Hard to determine if it was the GABA or external events. I have heard that GABA doesn’t cross the Brain Blood Barrier.
My concerns are the following:
I am very concerned about methyl trapping/ overmethylation/ feeling worse. Is this course of action ok until I get the 23and me back? I have heard that a COMT mutation could give me problems if I start on that routine. I don’t know if that amount of L-5-methf in relation to b12 is a concern. I do have aluminum show up in my blood tests.
Some have said just to keep niacin on hand in case I run into problems. I want to be as proactive as I can be while still being safe and not causing any other problems.
Is there anyway to test for the other SNPS (COMT, CBS etc) that is quicker than the 6 weeks that 23andme will take? I do live in NYS, so I know that makes things tricky (worst state for this kind of stuff). Should I do a urine provoked metals test?
I could share/post/send (how?) my bloodwork if anyone wants to see it. Is there any way to maybe illuminate whether or not I MAY have COMT from anything else in my bloodwork? Does the fact that I was taking 15mg of Deplin every day for 2 weeks mean anything? I was taking shots of B12 at one point too…
I am also seeing things online about Dr Yasko and getting the BHMT pathway moving first. This is very confusing. There is talk of getting Lithium in balance and other things. This is very confusing.
Any thought anyone can give me on my suggested regimine
Or
How I should proceed
Or
A quicker test available in NYS for those SNPS other than MTHFR
Again, I have a TON of bloodwork (neurotransmitters, homocysteine, methionine etc) that I’d be willing to send.
I am going to attempt to attach it to this post but it might be too large. I was doing some supplementing so it is reflected in the testing. It is a large pdf - 50 or so pages and it wouldn't attach - let me know if you need to see it.
Thank you in advance