@
stridor @
Violeta @
zzz0r
Thank-you for your responses! It was so supportive to wake up this morning and have all of your wisdom in my inbox
Here is what I'm taking:
Attempted dose of carnitine fumarate: approximately 85mg
Attempted dose of acetyl-l carnintine: 50mg
mB12 - 500 mcg in am- I used to take more, but then when I started the AdenosylB12, I needed to decrease because I was feeling overmethylated (+++agitation - I was a beast!)
mfolate: 165mcg in am, + 50mcg at lunch. *I had posted earlier in the week about addition of adenosylB12 & weight gain & @
Freddd had said to increase my methylfolate. I was reluctant to do so because increasing it before, again had turned me into that beast (+very quick to anger, insane energy). So I added this small dose at lunch, and that day the edema started to decrease & I was able to tolerate it as it was far enough away from my am dose.
Potassium: I was taking much more (almost a gram a day), but then when I started the adenosylB12, I needed to decrease it. I would just get super fatigued after taking it, a gross, yucky sludgy feeling. I'm taking 50mg in am, 50 mg in pm, and sometime 100mg at night if I find I'm craving potassium rich foods. I'm going to work on titrating this up but it is a fine line.
adenosylB12: 1.075mg in am: I noticed an immediate surge of energy when I started this, but I had to immediately adjust my mB12 dose as well as drop all of the other supplements that I was on from Yasko, I was taking Vitamin K, and Lactoferrin that she says helps with the ACAT mutations that have following role according to Yasko:
Contributing to energy production via the Krebs cycle and its impact on the mitochondria, which signal cellular activity and supply cellular energy …[specifically] The next portion of the pathway that may be impacted by ACAT is the level of acetyl CoA, which feeds into the top of the TCA cycle (also called the Krebs cycle) at 12:00. Benfotiamine, riboflavin, and pantothenic acid support the re- actions between pyruvate and the TCA cycle. ...A block at the acetyl CoA point of the Krebs/TCA cycle can also lead to both an accumulation of oxalates and increased levels of methylmalonic acid (MMA). To keep the cycle moving, the oxalates at 11:00 must combine with acetyl CoA coming in at 12:00. Low-dose vitamin K and lactoferrin help with that activity…. Both ACAT and high MMA levels are addressed the same way, with adenosyl B12, other forms of B12, low dose vitamin E succinate, lactoferrin, a sprinkle of actifol (ActiFolate), and nucleotides. MMA may inhibit succinate CoQ reduc- tase, which is vital for electron transport. Vitamin K (menaquinone) and CoQ 10 (ubiquinone) can serve as electron acceptors in these cases.
Interestingly at different points riboflavin, pantothenic acid, vitamin K, lactoferrin, CoQ10 have been removed from my supplement regimen due to causing more fatigue. Once removed I felt better.
@
Violeta that theory has been in the back of my mind for awhile too. I'm no scientist, and I described it almost as if I'm "overdriving" my energy systems. I have a baseline of hypoglycaemia caused by adrenal weakness. This was part of the first stages of me getting sick is that I started to have uncontrollable hypoglycaemia and I just couldn't get enough food in my body, it was like I was always hungry. I think my cells were starving for energy. I was training hard as a runner and was doing exceptionally well in terms of performance, but then I hit the wall and I had to substantially decrease my activity.
As well, I noted last night, ah, I did feel better once I ate something. And my husband said, wow, you must have been hungry, because I ate a lot! LOL! The heavy fatigue did not go away per se, but it subsided a bit.
This morning I feel odd. A little out of sorts. I have a very clear head. My mood is slightly on the agitated side, and I'm feeling a bit more edema. This is an interesting seesaw! I think today I will see how I feel, I might skip carnitine today, or at very least half it again.
Thanks again!