I don't get hypotension from NAC, and not sure if it's even possible for it to cause hypotension (it's just an amino acid).It worked well for me too for about 5 weeks. But I noticed that it increased hypotension somewhat. Then this has worsened. I don't know if having a big respiratory illness for several weeks now is to blame for the increased hypotension or the NAC. I cut back on the NAC one night with no change then cut it out the next, still with no change in my worsened hypotension.