23andme results

[Arizona]

I was hoping someone would be so kind as to help me interpret these results?

Gene & Variation​

rsID​

Alleles​

Result​

COMT V158M​

rs4680​

GG​

-/-​

COMT H62H​

rs4633​

CC​

-/-​

COMT P199P​

rs769224​

GG​

-/-​

VDR Bsm​

rs1544410​

CT​

+/-​

VDR Taq​

rs731236​

AG​

+/-​

MAO-A R297R​

rs6323​

GT​

+/-​

ACAT1-02​

rs3741049​

GG​

-/-​

MTHFR C677T​

rs1801133​

AG​

+/-​

MTHFR 03 P39P​

rs2066470​

GG​

-/-​

MTHFR A1298C​

rs1801131​

TT​

-/-​

MTR A2756G​

rs1805087​

AG​

+/-​

MTRR A66G​

rs1801394​

GG​

+/+​

MTRR H595Y​

rs10380​

CC​

-/-​

MTRR K350A​

rs162036​

AA​

-/-​

MTRR R415T​

rs2287780​

CC​

-/-​

MTRR A664A​

rs1802059​

GG​

-/-​

BHMT-02​

rs567754​

CC​

-/-​

BHMT-04​

rs617219​

CC​

+/+​

BHMT-08​

rs651852​

CT​

+/-​

AHCY-01​

rs819147​

TT​

-/-​

AHCY-02​

rs819134​

AA​

-/-​

AHCY-19​

rs819171​

TT​

-/-​

CBS C699T​

rs234706​

GG​

-/-​

CBS A360A​

rs1801181​

AA​

+/+​

CBS N212N​

rs2298758​

GG​

-/-​

SHMT1 C1420T
rs1979277
AG
+/-

Gene & Variation​

rsID​

Alleles​

Result​

CYP1A1*2C A4889G​

rs1048943​

TT​

-/-​

CYP1A1 m3 T3205C​

rs4986883​

TT​

-/-​

CYP1A1 C2453A​

rs1799814​

GG​

-/-​

CYP1A2 164A>C​

rs762551​

AA​

-/-​

CYP1B1 L432V​

rs1056836​

GG​

+/+​

CYP1B1 N453S​

rs1800440​

TT​

-/-​

CYP1B1 R48G​

rs10012​

GG​

-/-​

CYP2A6*2 1799T>A​

rs1801272​

AA​

-/-​

CYP2A6*20​

rs28399444​

II​

-/-​

CYP2C9*2 C430T​

rs1799853​

CC​

-/-​

CYP2C9*3 A1075C​

rs1057910​

AA​

-/-​

CYP2C19*17​

rs12248560​

CC​

-/-​

CYP2D6 S486T​

rs1135840​

GG​

+/+​

CYP2D6 100C>T​

rs1065852​

GG​

-/-​

CYP2D6 2850C>T​

rs16947​

AA​

+/+​

CYP2E1*1B 9896C>G​

rs2070676​

CC​

-/-​

CYP2E1*1B 10023G>A​

rs55897648​

GG​

-/-​

CYP2E1*4 4768G>A​

rs6413419​

GG​

-/-​

CYP3A4*1B​

rs2740574​

CT​

+/-​

CYP3A4*2 S222P​

rs55785340​

AA​

-/-​

CYP3A4*3 M445T​

rs4986910​

AA​

-/-​

CYP3A4*16 T185S​

rs12721627​

GG​

-/-​

GSTP1 I105V​

rs1695​

AG​

+/-​

GSTP1 A114V​

rs1138272​

CC​

-/-​

SOD2 A16V​

rs4880​

AA​

-/-​

NAT1 R187Q​

rs4986782​

GG​

-/-​

NAT1 R64W​

rs1805158​

CC​

-/-​

NAT2 I114T​

rs1801280​

TT​

-/-​

NAT2 R197Q​

rs1799930​

GG​

-/-​

NAT2 G286E​

rs1799931​

GG​

-/-​

NAT2 R64Q​

rs1801279​

GG​

-/-​

NAT2 K268R​

rs1208​

AA​

-/-​

Gene​

Result​

GSTT1​

Absent*​

​

 

[Valentijn]

Arizona
Heterozygous MTHFR C677T means methylfolate production is at 65% of normal. Hence supplementing with methylfolate (not folic acid) is probably going to be somewhat helpful.

Homozygous MTRR A66G means you need 3-4 times as much of it to function at a normal rate. B12 supplementation should help with that. Because your COMT, MAOA, and VDR aren't the particularly slow versions, you may have no problems tolerating methylB12. But if that makes you feel icky, hydroxoB12 might be a better option

GSTT1 is used to detox certain substances, and missing that gene indicates that you'll have a hard time doing that. It's used for amitriptyline and rituximab, and probably other drugs. It's also likely involved in detoxing pollutants and other environmental toxins, as there's an increased cancer risk associated with it.

 

[caledonia]

rsID

COMT V158M-/-
VDR Bsm+/-
VDR Taq+/-
MAO-A+/-
MTHFR C677T+/-
MTR A2756G+/-
MTRR A66G+/+
BHMT-04+/+
BHMT-08+/-
CBS A360A+/+
SHMT1 C1420T ???

CYP1B1 L432V+/+
CYP2D6 S486T+/+
CYP2D6 2850C>T+/+
CYP3A4*1B+/-
GSTP1 I105V+/-

I don't see the result for SHMT, so I can't comment on that.

You have one First Priority mutation, which is CBS, along with some BHMTs which can add to CBS. If you start on methyl supps and have a stress/anxiety reaction or a head pressure, CBS could be expressed, causing these problems. The Heartfixer page has good info on doing additional testing to see if CBS is expressed, and then a protocol to fix CBS, so you can tolerate methyl supps.

You have MTHFR C677T, so some methylfolate for that.

You have MTR and MTRR, which is the B12 double whammy (both B12 intake and recycling), so some B12 for that. For your COMT/VDR combo, Yasko suggests taking all three forms of B12 (hydroxy, adenosyl and methyl) but with less methylcobalamin.

VDR is the Vitamin D receptor. Get your vitamin D levels checked and supplement with that if it's low.

On the detox SNPs, CYP1B1 causes estrogen dominance and could cause estrogen related cancers such as breast or prostate.

CYP2D6 detoxifies 20% of prescription drugs, so you could have problems with those.

CYP3A4 detoxifies 50% of prescription drugs, so you could have problems with those.

GSTP affects glutathione, so you'll need more than usual.

​

 

[Arizona]

Thank you both for your input. This is all so confusing so I really appreciate your help. The SHMT is-

SHMT1 C1420T​

rs1979277​

AG​

+/-​

 

[Thomas]

I did 23andMe. How can I find the information you just posted?

 

[Arizona]

I went to the genetic genie website and connected to the 23andme website and then they give you this information.

 

[Thomas]

ah. thanks.

 

[Thomas]

Valentijn caledonia would you be so kind to analyze mine? I'm new here...thank you so much
Gene & Variation rsID Alleles Result
COMT V158M rs4680 GG -/-
COMT H62H rs4633 CC -/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO A R297R rs6323 T +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 CC -/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CC -/-
BHMT-04 rs617219 AA -/-
BHMT-08 rs651852 CC -/-
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 AA -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 GG -/-
SHMT1 C1420T rs1979277 AG +/-

 

[Valentijn]

Valentijn caledonia would you be so kind to analyze mine? I'm new here...thank you so much
Gene & Variation rsID Alleles Result
VDR Bsm rs1544410 CT +/-
MAO A R297R rs6323 T +/+
MTHFR C677T rs1801133 AG +/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR A664A rs1802059 AG +/-
SHMT1 C1420T rs1979277 AG +/-

MTHFR C677T being heterozygous means that methylfolate production is at 65% of normal, and SHMT1 can make this somewhat worse. Hence supplementing with methylfolate is probably necessary.

MTRR A66G means that you need 3 to 4 times as much MTRR for that gene to do its job at a normal rate. MTRR A664A and MTR A2756G being hetorozygous are also having a bit of an impact. Hence B12 supplementation is likely quite necessary as well. VDR and MAOA indicate that you might (or might not) have trouble tolerating high doses of methylB12. Hence if you do try high doses of B12, hydroxoB12 might be the safer form.

With your CBS being -/- it's possible that your homocysteine levels are elevated. If this is the case, then B6 might help. But it's probably a good idea to take the B12 for a while first, to make sure you're converting enough homocysteine into methionine with the B12, and the B6 is just cleaning up the leftovers.

 

[caledonia]

Thank you both for your input. This is all so confusing so I really appreciate your help. The SHMT is-

SHMT1 C1420T​

rs1979277​

AG​

+/-​

The SHMT is another First Priority mutation, so some folinic acid for that.

 

[caledonia]

Valentijn caledonia
Gene & Variation rsID Alleles Result
COMT V158M rs4680 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO A R297R rs6323 T +/+
MTHFR C677T rs1801133 AG +/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR A664A rs1802059 AG +/-
SHMT1 C1420T rs1979277 AG +/-

You have one First Priority mutation, which is SHMT, so some folinic acid for that.

You have MTHFR C677T so some methylfolate for that.

You have both MTR and MTRR (B12 intake and recycling), which is the B12 double whammy, so some B12 for that.

For your COMT/VDR combo, Yasko suggests all three forms of B12 (hydroxycobalamin, adenosylcobalamin, and methylcobalamin), but with less methylcobalamin.

You have VDR which is the Vitamin D Receptor, so get that tested, and if it's low, supplement for that.

MAO affects serotonin. Yasko suggests working on that last after doing all the other methyl stuff. If you still have anxiety/depression or other serotonin issues, then she suggests some 5htp (a serotonin precursor) for that.

 

[Arizona]

GSTT1 is used to detox certain substances, and missing that gene indicates that you'll have a hard time doing that. It's used for amitriptyline and rituximab, and probably other drugs. It's also likely involved in detoxing pollutants and other environmental toxins, as there's an increased cancer risk associated with it.

Is there anything I can do or anything I can take that would help with this?

 

[Valentijn]

Is there anything I can do or anything I can take that would help with this?

It might help to try to increase glutathione levels, since that could increase the odds of it hooking up to the substances which GSTT1 usually facilitates.

Glutathione is formed of glutamate, glycine, and cysteine. I think we pretty much always have more than enough glutamate, but supplementing cysteine (N-acetylcysteine = NAC) might help, and/or supplementing glycine.