my 23andme results ?

[xks201]

Any input?


Gene & Variation rsID Alleles ResultCOMT V158M rs4680 AA +/+COMT H62H rs4633 TT +/+COMT P199P rs769224 GG -/-VDR Bsm rs1544410 CC -/-VDR Taq rs731236 AA +/+VDR Fok-I not found n/a n/aMAO A R297R rs6323 T +ACAT1-02 rs3741049 GG -/-MTHFR C677T rs1801133 GG -/-MTHFR 03 P39P rs2066470 GG -/-MTHFR A1298C rs1801131 GT +/-MTR A2756G rs1805087 AA -/-MTRR A66G rs1801394 AG +/-MTRR H595Y rs10380 CC -/-MTRR K350A rs162036 AA -/-MTRR R415T rs2287780 CC -/-MTRR S257T not found n/a n/aMTRR A664A rs1802059 AG +/-BHMT-01 not found n/a n/aBHMT-02 rs567754 CT +/-BHMT-04 rs617219 AC +/-BHMT-08 rs651852 CT +/-AHCY-01 rs819147 TT -/-AHCY-02 rs819134 AA -/-AHCY-19 rs819171 TT -/-CBS C699T rs234706 GG -/-CBS A360A rs1801181 AA +/+CBS N212N rs2298758 GG -/-SUOX S370S not found n/a n/aNOS3 D298E not found n/a n/aSHMT1 C1420T rs1979277 AG +/-

 

[Valentijn]

COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
VDR Taq rs731236 AA +/+
MAO A R297R rs6323 T +
MTHFR A1298C rs1801131 GT +/-
MTRR A66G rs1801394 AG +/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 AA +/+
SHMT1 C1420T rs1979277 AG +/-

I've crossed out the SNPs where there's no research showing any risk.

Based on this info, you shouldn't be having much of a folate problem. SHMT's is only shown to cause problems when combined with a MTHFR variation which you don't have.

MTRR A66G has a pretty big impact when homozygous, hence your heterozygous version is probably slowing down MTR recycling as well. B12 supplementation might help that .

With your versions of MAOA and COMT, you might be slow at using methyl groups up while breaking down neurotransmitters. Hence high dose supplementation with methyl groups might be unpleasant, and hydroxoB12 might be less upleasant than methylB12.

BHMT and CBS can result in increased homocysteine. The risky version CBS C699T is reported backwards by Yasko and geneticgenie. Basically you have the slower version, which is the riskier one. B6 can help reduce homocysteine here if it's elevated.

SUMMARY:
Normal doses of B6, methylfolate, and B12 may be helpful. If trying higher doses of B12, hydroxoB12 might be the safer form.

 

[xks201]

Wow thanks. So it looks like I may be an overmethylater? No major comt mutations? Perhaps is benefot most from a mao a inhibitor ehen when it came to nervius system drugs?

 

[Valentijn]

Wow thanks. So it looks like I may be an overmethylater? No major comt mutations? Perhaps is benefot most from a mao a inhibitor ehen when it came to nervius system drugs?

Hard to say. There are other SNPs on those genes which might be having an impact, but you'd have to look them up manually - no easy program for them yet.

They're listed on the "Genetic Testing and SNPs" board, with titles of "Interesting COMT Variations" (or MTHFR, MTR, VDR, etc).