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Rich postulated that taking high doses of Vitamin C could reduce Glutathione in the body? Has anyone any experience with this, or been able to verify from other sources?
The idea is that the lower dosages supply antioxidant support without placing too large a demand on glutathione, which is depleted in many cases of CFS, mid-range dosages place a demand on glutathione for recycling vitamin C (according to Dr. Cheney, and I think he's right), and bowel tolerance dosages are able
to raise the vitamin C concentrations sufficiently that vitamin C recycles glutathione, rather than glutathione recycling vitamin C, as is normal.
So are bowel tolerance doses good?
I guess it depends on what your goal is. In this case, he was saying that bowel tolerance doses would be increasing glutathione by "recycling" it. For Rich, I think that would mean "good!"
Sushi
Sasha
Looks like it would be the 'mid-range' doses of Vit C that could deplete glutathione. When we asked Rich about this he said (this is from memory, so there is a 'duh' factor!) that mid-range was say, 3000--6000 mgs.
Sushi
Wow 45g a day is a massive amount. The question is at what point does Vitamin C start to recycle and Glutathione is this really related to bowel tolerance -- 3000-6000mgs could be the tolerance level for some people?
Again hard to know what to do with this information (postulation). If the level of vitamin c we are taking is placing too much of a demand on glutathione, what are the symptoms?
So lower would be safer, to some extent, but then there are lots of proponents out there hailing the benefits of large dosages of Vitamin C. Comes down to trial and error in the end.
I took that mega-mega-dose during my first illness, during which I was almost completely confined to bed. Like pretty much everything I tried, it had no effect one way or another. Some years later I had a remission, lasting several years, and now I've been housebound for several years. I suspect that whatever I try, it will be hard to discern any immediate effect - hard to know how long to give it as a test.