There is a good article on the HLA-DR here:
HLA-DR - Wikipedia, the free encyclopedia
This article mentions that the genetics of the HLA-DR is complex, and I guess this means these genetics do not easily map onto the SNP variations found in the 23andme.com genotyping results. I was hoping that the 23andme results would determine your mold toxin susceptibility, but I guess this is not the case.
Your 23andme results do tell you if you are susceptible to organophosphate pesticides, though; see this thread:
23andme - question about PON1 gene rs662
Basically, if your rs662 SNP is the TT allele, then your are more susceptible to organophosphate pesticides. The rs662 SNP is within the
PON1 gene — a gene which determines how well you detoxify organophosphates.
For those who have taken the 23andme test, to see your rs662 allele on the 23andme website,
click here.
Organophosphate exposure would seem to increase your risk of developing ME/CFS by a factor of 4 (ref
here). But I imagine that if you have the TT risk allele, organophosphate exposure will present even a higher risk of developing ME/CFS.
Mold toxins and organophosphates appear to be the main environmental toxins linked to triggering ME/CFS. I think these toxins likely precipitate ME/CFS in combination with infectious agents.