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Interesting news via the HHV-6 Foundation

SOC

Senior Member
Messages
7,849
I just happened across these while looking at the HHV-6 Foundation website for something else and thought others might be interested in digging into them further.
Researchers at the University of Alabama at Birmingham have reported that a set of novel methylenecyclopropane (MCP) nucleoside analogs, synthesized by Microbiotix, Inc., have shown increased activity against a broad spectrum of human herpesviruses. The new agents are derivations of the compound cyclopropavir (CPV), currently in human phase I clinical studies, which has previously been shown to exhibit good antiviral activity against human beta-and gamma-herpes viruses, including HCMV, EBV, HHV-6A, HHV-6B, and HHV-8. In addition, all but one of the new analogs had potent anti-viral activity against HHV-6B that was greater than that of cidofovir (CDV).
Furthermore, some of the new analogs have demonstrated an even broader spectrum of anti-herpes activity, with significant inhibition of the alpha-herpes viruses HSV-1, HSV-2, and VZV as well.

A new group of antiherpetics (antivirals against herpesviruses) that addresses the entire class (rather than only alphas or betas or gammas) could be a huge boon for ME/CFS patients. The fact that it's already in Phase 1 trials gives hope for a new treatment sooner than 10-15 years out. :)
Dr. Jussi Oskari Virtanen, who works in Steve Jacobson’s laboratory at the NINDS, has published findings that further strengthen the relationship between HHV-6, EBV, and multiple sclerosis. The report demonstrates that 24% of 37 CSF samples from MS patients had HHV-6 reactive oligoclonal bands (OCBs) and 14% had EBV OCBs, compared to none in patients with other inflammatory neurological diseases (p=0.005). In addition, brain imaging analysis also showed that MS patients with viral DNA detected in the CSF exhibited more brain contrast enhancing lesions (CELs) than those who were virus-negative.
NIH-NINDS-Building-e1371154624154.jpg

A new study from NIH/NINDS further strengthens the relationship between HHV-6, EBV, and multiple sclerosis.
The authors of the study point out that several previous publications have identified OCBs reactive to HHV-6, EBV, and c. pneumonia in the spinal fluid of MS patients.
As an ME/CFS patient with (at one time) active hhv6, ebv, and c. pneumonia infections, I find this interesting. This is not a completely unusual combination of viruses in ME/CFS, so I wonder if there is a closer association among a subset of PWME and MS than has been believed.
We desperately need more research into the CSF of ME/CFS patients.
 

vli

Senior Member
Messages
653
Location
CA
I just happened across these while looking at the HHV-6 Foundation website for something else and thought others might be interested in digging into them further.

A new group of antiherpetics (antivirals against herpesviruses) that addresses the entire class (rather than only alphas or betas or gammas) could be a huge boon for ME/CFS patients. The fact that it's already in Phase 1 trials gives hope for a new treatment sooner than 10-15 years out. :)
This is good news, however, i wonder whether they'd give it to *PWC*s too? (Since right now, we have trouble even getting valcyte or vistide bc they don't think OUR condition's linked to herpes viruses)
 

SOC

Senior Member
Messages
7,849
This is good news, however, i wonder whether they'd give it to *PWC*s too? (Since right now, we have trouble even getting valcyte or vistide bc they don't think OUR condition's linked to herpes viruses)

Certainly not in the UK, where getting any decent medical treatment for ME/CFS is particularly difficult. Hopefully by the time this med is through all its testing and to market, the situation there will improve. In the US, Australia, and some other countries where there are smart ME/CFS specialists already using antivirals, these meds should take off more quickly.
 

Charles555nc

Senior Member
Messages
572
I use high dose NAC (worked up to 3600mg) for c pneumoniae infection and it was also the main treatment for AIDS patients before retrovirals were available- so I use it for my hhv6/CMV/Epstein barr infection as well. Its antibiofilm, anti biopolar (boosted my confidence and mood stability, so I gave it to my crazy mother), anti COPD, anticancer...

I take large doses of methyl folate (1600mg twice a day) with the NAC to prevent a methylation block as glutathione levels rise.
 

SOC

Senior Member
Messages
7,849
I use high dose NAC (worked up to 3600mg) for c pneumoniae infection and it was also the main treatment for AIDS patients before retrovirals were available- so I use it for my hhv6/CMV/Epstein barr infection as well. Its antibiofilm, anti biopolar (boosted my confidence and mood stability, so I gave it to my crazy mother), anti COPD, anticancer...

I take large doses of methyl folate (1600mg twice a day) with the NAC to prevent a methylation block as glutathione levels rise.

With all those anti-something characteristics, it sounds like we should all be taking NAC by the truckload. ;)

Seriously though, I've been thinking about increasing my NAC. I need to go hunt up info on side effects, safe dosages, interactions, and so on. I have some sources I use, but if anyone has a really good source for that kind of info on supplements, I'd love to hear about it.
 
Messages
15,786
With all those anti-something characteristics, it sounds like we should all be taking NAC by the truckload. ;)

Seriously though, I've been thinking about increasing my NAC. I need to go hunt up info on side effects, safe dosages, interactions, and so on. I have some sources I use, but if anyone has a really good source for that kind of info on supplements, I'd love to hear about it.
There's been lots of AIDS studies using NAC. 1800mg is definitely safe long term, and it can go higher based on body weight. I think you need to go to something like 10x that dose to get into a known risky area.

The only risk at normal doses seems to be if you have an issue with kidney stones, specifically ones made of cysteine. If not, then it should be quite safe.
 

heapsreal

iherb 10% discount code OPA989,
Messages
10,089
Location
australia (brisbane)
parvolex is the drug name for it used in hospitals for paracetamol overdoses. You might find more info googling that name too. It is given IV in hospital but i do remember reading a study that showed efficiency with an oral form too, but i dont have that study on hand.