Well this tells me a lot. Have you been able to look into Yasko's work?
My hunch may have been right re: tyrosine/dopamine connection. It's funny. I was a vegetarian for many years as well. And my health did not improve until I ate meat. I had several experts tell me I needed to do so, and I fought it tooth & nail, as my vegetarianism was so much part of my self-identity. It is a sensitive subject for many, I am aware of this, and do not mean to minimize one's committment to vegetarianism. For me, I had never really been attracted to meat, & I believe that this was related to my CBS issues, and chronic buildup of ammonia with meat consumption (highly related to brain fog).
A1298C can be related to BH4 issues (the production of which is essential for neurotransmitter production - like dopamine & serotonin - essential key players in motivation & the feeling of having energy). From Yasko: MTHFR A1298C mutations (if present) impair the second leg by disrupting the recycling and regeneration of BH4.... Keeping the ammonia levels under control is of paramount importance for overall health and wellness, especially for those with an MTHFR A1298C mutation, as any excess ammonia generated can drain stores of BH4.
Ammonia production is handled by following CBS protocol.
The third leg as Yasko describes it to BH4 production is gut health, and this becomes of paramount importance for those with known CBS mutations and MTHFR A1298C mutations.
Ah, I like this one better:
http://www.aor.ca/products-page/classic/hydroxy-12/
I think you can get it from iherb if you can't buy locally. It doesn't have Magnesium in it. And it's a smaller amount. When I started I had to 1/4 this tablet, which would be 500mcg, and take only every other day. Don't assume that you have to take the B12 everyday (apple-a-day mentality that we are fed). Some people can only tolerate the B12s a few times per week at a tiny, tiny dose
My official diagnosis is HH6 encephalitis, but I started hanging out here bec the symptoms are similar. I have sky-high antibody level.
Ah, okay. I am not familiar with that diagnosis. Is it viral? The name suggests an inflammatory process which could explain your strong reactions to B12. From Yasko: There is a reciprocal
relationship between methylation and inflammation, almost as if they
were on a seesaw: increased inflammation will tend to decrease methylation and
vice versa.
If it's viral, is there an antiviral treatment for your condition? Have you tried an anti-inflammatory like Curcumin. There are also significant dietary contributants to chronic inflammation, and Yasko speaks about the relationship between viral infections and metal toxicity.
Supports to Address Inflammation (from Yasko):
Nettle
Boswellia
Curcumin (limited amounts for COMT V158M ++)
Skull cap
Chamomile
Quercetin
Petadolex (Butterbur)
Cherry fruit extract
General Inflammatory Pathway RNA
HyperImmune RNA (limited amounts for COMT V158M ++)
Cytokine Inflammatory Pathway RNA
Advanced Joint Inflammatory Path. RNA
Stress Foundation RNA
Lung Support RNA
Colostrum
Kidney Inflammatory Pathway RNA
Decrease in fatigue, ability to think more clearly (I can now understand posts on this forum, which I could not before). Symptoms return 48 hours after I stop or decrease dosage. Currently 1100 mg/day, in 4 doses.
Ah, okay. When you say Folopro are you referencing the Metagenics Folate (as L-5-methyl tetrahydrofolate†)? This is quite a remarkable response that you have had. Any reason why you are taking hydroxy-B12 instead of trying the methyl-B12? Seems to me that you may need the methyl form, and your body is unable to deal with the non-methyl form. This could definitely account for some of your symptoms. I think peeps on here like the Jarrow methyl B12. It's quite possible that you might respond well to SAMe or methionine as well if you haven't tried, but one step @ a time.
For mental clarity, I found that Acetyl-L Carnitine, really, really, helped me. It's also possible that you may be low in this especially as Carnitine is found naturally in red meat. I like the NOW foods brand
Star