- Messages
- 34
- Location
- Canada
Hi guys,
I downloaded my raw data from 23andme and uploaded to Genetic Genie.
I'm herterozygous for MTHFR C677T. I know I need folic acid and B12 in the methyl form.
I'm really surprised to see I'm -/- for A1298C since I've always been told I had CFS/FM.
I read that having MTHFR mutations can make you prone to infections and detoxing which are my issues. Do one of the mutations (C677T and A1298C) cause that more than the other as I just have a problem with C677T.
Any suggestions on how to treat the other mutations would be greatly appreciated. There is less info about them compared to MTHFR. I know some are a concern. I will check out Dr. Yasko's website for more info.
Here are are my results:
Methlyation Analysis:
Gene & Variation rsID Alleles Result
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CC -/-
VDR Taq rs731236 AA +/+
VDR Fok-I not found n/a n/a
MAO A R297R rs6323 GT +/-
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 CC -/-
MTRR S257T not found n/a n/a
MTRR A664A rs1802059 GG -/-
BHMT-01 not found n/a n/a
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 CT +/-
AHCY-02 rs819134 AG +/-
AHCY-19 rs819171 CT +/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 GG -/-
SUOX S370S not found n/a n/a
NOS3 D298E not found n/a n/a
SHMT1 C1420T rs1979277 GG -/-
Detox Profile:
Gene & Variation rsID Alleles Result
CYP1A1*2C A4889G rs1048943 TT -/-
CYP1A1 m3 T3205C rs4986883 TT -/-
CYP1A1 C2453A rs1799814 GG -/-
CYP1A2 164A>C rs762551 AA -/-
CYP1B1 L432V rs1056836 CG +/-
CYP1B1 N453S rs1800440 TT -/-
CYP1B1 R48G rs10012 CG +/-
CYP2A6*2 1799T>A rs1801272 AA -/-
CYP2A6*20 rs28399444 II -/-
CYP2C9*2 C430T rs1799853 CT +/-
CYP2C9*3 A1075C rs1057910 AA -/-
CYP2C19*17 rs12248560 CC -/-
CYP2D6 S486T rs1135840 CG +/-
CYP2D6 100C>T rs1065852 AG +/-
CYP2D6 2850C>T rs16947 GG -/-
CYP2E1*1B 9896C>G rs2070676 CC -/-
CYP2E1*1B 10023G>A rs55897648 GG -/-
CYP2E1*4 4768G>A rs6413419 GG -/-
CYP3A4*1B rs2740574 TT -/-
CYP3A4*2 S222P rs55785340 AA -/-
CYP3A4*3 M445T rs4986910 AA -/-
CYP3A4*16 T185S rs12721627 GG -/-
GSTP1 I105V rs1695 GG +/+
GSTP1 A114V rs1138272 CC -/-
SOD2 A16V rs4880 AG +/-
NAT1 R187Q rs4986782 GG -/-
NAT1 R64W rs1805158 CC -/-
NAT2 I114T rs1801280 CC +/+
NAT2 R197Q rs1799930 GG -/-
NAT2 G286E rs1799931 GG -/-
NAT2 R64Q rs1801279 GG -/-
NAT2 K268R rs1208 GG +/+
I've been sick 29 years, since I was 15. I figured I had CFS/FM. I suffer constant fatigue and muscle pain plus 40 other symptoms. I have hypothyroidism, adrenal exhaustion, and chronic systemic candida all these years. Recently I found out I have Lyme disease. My tests were negative according to the CDC and IGenex but I had 4 INF's and one + on lyme specific bands so I've obviously been exposed to it. It also showed up on energetic tests I did along with Babesia and Bartonella. That energetic test also revealed I have many viruses, staph, parasites, worms (not seen in the bowel so must be microscopic). I also have high mold toxins in my body. There is a certain gene I need to test for that. I don't think it's in 23andme results. I have to detox the mold toxins first if I want to heal from Lyme. And I have mercury poisoning as well as aluminum, arsenic, tin and titanium.
So I'm a mess. No matter what I do to get well, I can't. So maybe it's the genes and particular MTHFR C677T though it's just herterozygous and working at 70% (some say 50-70%) compared to homozygoys 30%. Can anyone shed light on other problem mutations and what supps I should take?
I thought there was going to be a couple HLA genes related to mold (according to mthfrsupport.com) but they aren't there. Guess 23andme has taken them out.
I should add my last homocysteine test was 5.8 (range <13).
Here is my symptom list:
*extreme muscle pain and inflammation (muscles spasm, ache, seize up, feel inflamed)
*extreme fatigue
*hypothyroidism
*hair falls out easily
*adrenal exhaustion (still tired even when thyroid is in range)
*excessive in take of salt
*dizziness (especially rising from the ground to stand up)
*constipation
*digestive problems (always hungry, acid reflux in lower stomach)
*chronic sinusitis (daily)
*systemic candida
*excessive vaginal discharge especially after period (thin, clear), sometimes yellow
*chronic mouth ulcers (canker) and cold sores (since a child)
*get cold easily, hands and feet sometimes cold
*heavy metal poisoning (mercury, aluminum, arsenic, tin, titanium. Had high levels of copper at one time but not anymore)
heart pain (stabbing pain, tenderness)
tenderness in chest area, near breast
body temperature sometimes fluctuates
easily startled
feel wired at night sometimes even though tired
strep (B) (Naturopath said I had high levels in my system)
have had one seizure
had many fainting spells as a kid and adult
lethargic
low to normal blood pressure
diagnosed with Lichen Planus in mouth as a teen (like thrush/candida)
break out in a sweat easily
metallic taste in mouth
memory problems (brain fog)
sensitive to noise
eyes sensitive to sunlight (easily turn red) and bright lights
dry eyes (can't wear contacts)
ringing in ears
thick saliva (could be candida/other infections)
flushed face (red)
eyelids sometimes twitch
dark circles under eyes
occasional tender lymph nodes under armpits
legs jolt me awake when sleeping
don't seem to dream
headaches/migraines
leg cramps
sometimes night sweats
knee, hip, and thumb pain (joints)
hip dysplasia (wants to dislocate)
Knee dislocation (twice, had surgery in 1987)
Anemic
low vitamin D
low to normal blood pressure
lost 3 fingernails that grew back (systemic candida/fungus) (1987)
dry patch of skin behind ear and on back of earlobe
dry scalp at lower back of head
Around 1998 had CD4 Lymphopenia (low T helper cells) 600 (I'm HIV negative).
Boil on chin (1995).
Saliva tests show adrenal exhaustion. Mineral hair analysis shows moderate degree of adrenal insufficiency. (Phase 3 The Exhaustion Stage, final stage). Naturopath and a Medical Intuitive say adrenal exhaustion as well but this doesn't show in standard blood work.
In May 2009 I was diagnosed with UARS. (Upper Airway Resistance Syndrome). This is a precursor to Sleep Apnea. In sleep apnea a person stops breathing many times a night and with UARS their passageway narrows making it hard to get air (like breathing through a coffee straw). During the night my heart rate stays up because I'm working hard to get enough air and therefore I'm not able to go into a deep sleep. Cpap is used for treatment but it didn't help me at all even though my heart rate settled down with use. I have sometimes wonder if I have this sleep disorder or maybe I have it in combination with something else that's making me sick.
August 2010 I saw a mitochondria specialist and they found no problems other than I was mildly low in Free and Total carnitine. I didn't feel any better taking carnitine supplement.
Sept. 2010 Waiting for confirmation of Vlcad which is a fatty oxidation disorder.
Feb. 2011 Vlcad final test was negative.
May 2012 Found out I have high fluoride and bromide levels in my body which prevent iodine from getting into my cells for proper thyroid function. I live in an area where we don't fluoridate the water. Have been avoiding toothpaste with fluoride.
Oct. 2012 Energetic testing showed I had high levels of staph, candida, small parasites, worms, mold toxins, inflammation. I also had decent levels of the following viruses: LYV, MAV, LFV, CAV, SAV, TBV plus Lyme, Babesia and Bartonella.
Dad died at 68 of CHF (diagnosed at 58), had his heart shocked a few times for atrial fibrillation and had 2 angioplasties, also had diabetes.
His sisters have diabetes, one died from cancer the other suffers from alcoholism.
His Dad died in early 50's from heart attack. Had diabetes and polio.
His Mom died at 86 from a heart attack
Mom died at 58 of Intracerebral Hemorrhage and Sequelae due to or as a consequence of Idiopathic Thrombocytopenic Purpura (Blood test revealed she had only 4 platelets in sample. They think a virus may have caused this but don't really know. They didn't think she had cancer).
Mom's half siblings have cholesterol problems, one diagnosed with mild MS
Her Dad died in WW2 of Tuberculosis
Her Mom died at 92 of CHF and kidney failure. Also had dementia, anxiety and depression.
Thanks for any advice,
Cheryl
I downloaded my raw data from 23andme and uploaded to Genetic Genie.
I'm herterozygous for MTHFR C677T. I know I need folic acid and B12 in the methyl form.
I'm really surprised to see I'm -/- for A1298C since I've always been told I had CFS/FM.
I read that having MTHFR mutations can make you prone to infections and detoxing which are my issues. Do one of the mutations (C677T and A1298C) cause that more than the other as I just have a problem with C677T.
Any suggestions on how to treat the other mutations would be greatly appreciated. There is less info about them compared to MTHFR. I know some are a concern. I will check out Dr. Yasko's website for more info.
Here are are my results:
Methlyation Analysis:
Gene & Variation rsID Alleles Result
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CC -/-
VDR Taq rs731236 AA +/+
VDR Fok-I not found n/a n/a
MAO A R297R rs6323 GT +/-
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 CC -/-
MTRR S257T not found n/a n/a
MTRR A664A rs1802059 GG -/-
BHMT-01 not found n/a n/a
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 CT +/-
AHCY-02 rs819134 AG +/-
AHCY-19 rs819171 CT +/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 GG -/-
SUOX S370S not found n/a n/a
NOS3 D298E not found n/a n/a
SHMT1 C1420T rs1979277 GG -/-
Detox Profile:
Gene & Variation rsID Alleles Result
CYP1A1*2C A4889G rs1048943 TT -/-
CYP1A1 m3 T3205C rs4986883 TT -/-
CYP1A1 C2453A rs1799814 GG -/-
CYP1A2 164A>C rs762551 AA -/-
CYP1B1 L432V rs1056836 CG +/-
CYP1B1 N453S rs1800440 TT -/-
CYP1B1 R48G rs10012 CG +/-
CYP2A6*2 1799T>A rs1801272 AA -/-
CYP2A6*20 rs28399444 II -/-
CYP2C9*2 C430T rs1799853 CT +/-
CYP2C9*3 A1075C rs1057910 AA -/-
CYP2C19*17 rs12248560 CC -/-
CYP2D6 S486T rs1135840 CG +/-
CYP2D6 100C>T rs1065852 AG +/-
CYP2D6 2850C>T rs16947 GG -/-
CYP2E1*1B 9896C>G rs2070676 CC -/-
CYP2E1*1B 10023G>A rs55897648 GG -/-
CYP2E1*4 4768G>A rs6413419 GG -/-
CYP3A4*1B rs2740574 TT -/-
CYP3A4*2 S222P rs55785340 AA -/-
CYP3A4*3 M445T rs4986910 AA -/-
CYP3A4*16 T185S rs12721627 GG -/-
GSTP1 I105V rs1695 GG +/+
GSTP1 A114V rs1138272 CC -/-
SOD2 A16V rs4880 AG +/-
NAT1 R187Q rs4986782 GG -/-
NAT1 R64W rs1805158 CC -/-
NAT2 I114T rs1801280 CC +/+
NAT2 R197Q rs1799930 GG -/-
NAT2 G286E rs1799931 GG -/-
NAT2 R64Q rs1801279 GG -/-
NAT2 K268R rs1208 GG +/+
I've been sick 29 years, since I was 15. I figured I had CFS/FM. I suffer constant fatigue and muscle pain plus 40 other symptoms. I have hypothyroidism, adrenal exhaustion, and chronic systemic candida all these years. Recently I found out I have Lyme disease. My tests were negative according to the CDC and IGenex but I had 4 INF's and one + on lyme specific bands so I've obviously been exposed to it. It also showed up on energetic tests I did along with Babesia and Bartonella. That energetic test also revealed I have many viruses, staph, parasites, worms (not seen in the bowel so must be microscopic). I also have high mold toxins in my body. There is a certain gene I need to test for that. I don't think it's in 23andme results. I have to detox the mold toxins first if I want to heal from Lyme. And I have mercury poisoning as well as aluminum, arsenic, tin and titanium.
So I'm a mess. No matter what I do to get well, I can't. So maybe it's the genes and particular MTHFR C677T though it's just herterozygous and working at 70% (some say 50-70%) compared to homozygoys 30%. Can anyone shed light on other problem mutations and what supps I should take?
I thought there was going to be a couple HLA genes related to mold (according to mthfrsupport.com) but they aren't there. Guess 23andme has taken them out.
I should add my last homocysteine test was 5.8 (range <13).
Here is my symptom list:
*extreme muscle pain and inflammation (muscles spasm, ache, seize up, feel inflamed)
*extreme fatigue
*hypothyroidism
*hair falls out easily
*adrenal exhaustion (still tired even when thyroid is in range)
*excessive in take of salt
*dizziness (especially rising from the ground to stand up)
*constipation
*digestive problems (always hungry, acid reflux in lower stomach)
*chronic sinusitis (daily)
*systemic candida
*excessive vaginal discharge especially after period (thin, clear), sometimes yellow
*chronic mouth ulcers (canker) and cold sores (since a child)
*get cold easily, hands and feet sometimes cold
*heavy metal poisoning (mercury, aluminum, arsenic, tin, titanium. Had high levels of copper at one time but not anymore)
heart pain (stabbing pain, tenderness)
tenderness in chest area, near breast
body temperature sometimes fluctuates
easily startled
feel wired at night sometimes even though tired
strep (B) (Naturopath said I had high levels in my system)
have had one seizure
had many fainting spells as a kid and adult
lethargic
low to normal blood pressure
diagnosed with Lichen Planus in mouth as a teen (like thrush/candida)
break out in a sweat easily
metallic taste in mouth
memory problems (brain fog)
sensitive to noise
eyes sensitive to sunlight (easily turn red) and bright lights
dry eyes (can't wear contacts)
ringing in ears
thick saliva (could be candida/other infections)
flushed face (red)
eyelids sometimes twitch
dark circles under eyes
occasional tender lymph nodes under armpits
legs jolt me awake when sleeping
don't seem to dream
headaches/migraines
leg cramps
sometimes night sweats
knee, hip, and thumb pain (joints)
hip dysplasia (wants to dislocate)
Knee dislocation (twice, had surgery in 1987)
Anemic
low vitamin D
low to normal blood pressure
lost 3 fingernails that grew back (systemic candida/fungus) (1987)
dry patch of skin behind ear and on back of earlobe
dry scalp at lower back of head
Around 1998 had CD4 Lymphopenia (low T helper cells) 600 (I'm HIV negative).
Boil on chin (1995).
Saliva tests show adrenal exhaustion. Mineral hair analysis shows moderate degree of adrenal insufficiency. (Phase 3 The Exhaustion Stage, final stage). Naturopath and a Medical Intuitive say adrenal exhaustion as well but this doesn't show in standard blood work.
In May 2009 I was diagnosed with UARS. (Upper Airway Resistance Syndrome). This is a precursor to Sleep Apnea. In sleep apnea a person stops breathing many times a night and with UARS their passageway narrows making it hard to get air (like breathing through a coffee straw). During the night my heart rate stays up because I'm working hard to get enough air and therefore I'm not able to go into a deep sleep. Cpap is used for treatment but it didn't help me at all even though my heart rate settled down with use. I have sometimes wonder if I have this sleep disorder or maybe I have it in combination with something else that's making me sick.
August 2010 I saw a mitochondria specialist and they found no problems other than I was mildly low in Free and Total carnitine. I didn't feel any better taking carnitine supplement.
Sept. 2010 Waiting for confirmation of Vlcad which is a fatty oxidation disorder.
Feb. 2011 Vlcad final test was negative.
May 2012 Found out I have high fluoride and bromide levels in my body which prevent iodine from getting into my cells for proper thyroid function. I live in an area where we don't fluoridate the water. Have been avoiding toothpaste with fluoride.
Oct. 2012 Energetic testing showed I had high levels of staph, candida, small parasites, worms, mold toxins, inflammation. I also had decent levels of the following viruses: LYV, MAV, LFV, CAV, SAV, TBV plus Lyme, Babesia and Bartonella.
Dad died at 68 of CHF (diagnosed at 58), had his heart shocked a few times for atrial fibrillation and had 2 angioplasties, also had diabetes.
His sisters have diabetes, one died from cancer the other suffers from alcoholism.
His Dad died in early 50's from heart attack. Had diabetes and polio.
His Mom died at 86 from a heart attack
Mom died at 58 of Intracerebral Hemorrhage and Sequelae due to or as a consequence of Idiopathic Thrombocytopenic Purpura (Blood test revealed she had only 4 platelets in sample. They think a virus may have caused this but don't really know. They didn't think she had cancer).
Mom's half siblings have cholesterol problems, one diagnosed with mild MS
Her Dad died in WW2 of Tuberculosis
Her Mom died at 92 of CHF and kidney failure. Also had dementia, anxiety and depression.
Thanks for any advice,
Cheryl