Ok I have hemachromatosis too so let me give you something to think about. If your ferritin is below 100 you will feel tired. If it is in the single digits like mine was on phlebotomies for a long time then all the folate in the universe will NOT get rid of the fatigue. Regardless of what is discussed on these forums, there are other things than folate and mb12.
Iron is hugely important. I understand the concerns regarding hemachromatosis. What was your ferritin levels when the doctors diagnosed you? Mine was 500. They drained me and kept me low for eight years. It has taken me another six years to get my ferritin back above 100. Be careful. Low iron especially anemia is one of the worst stress you can subject your body to. Also riboflavin / r5p is critical to iron storage; vitamin A in an opposite manner.
The metallic taste can be several things. For me it always meant I needed more zinc. Based on your SNPs I have no idea why you are on hb12. Just my opinion. The p5p is an essential part of the methylation protocol. The dose is up to you but 25mg is probably an ok amount to experiment with. The MCV suggests your mb12 is very low. That would be expected from some of your MTR and MTRR problems. Maybe you need methionine supplements now, see how they do, get other supports in place and then try to wean off it over time. Dunno for sure. If you are not taking B2 of any type, I would seriously consider it.
What are your ferritin, iron serum, TIBC, and hematocrit number like nowadays? Taking supplemental iron is always dangerous if you have hemachromatosis. But you may need to reconsider any further phlebotomies. Also what hemachromatosis mutations do you have. The distinction between which ones makes a BIG difference. I am compound heterozygote which makes my hemachromatosis highly variable and dependent on epigenetic triggers.
Great to 'talk' with someone who has an understanding of HHC as well as Methylation issues. I have C282Y +/+, which in theory is the worst. My Father had C677Y/H63D and was a blood donor a couple of times a year for around 40 years, so when he was diagnosed at 80 his levels were all fine. My kid brother has C282Y +/-, which in theory is no big deal, but at diagnosis his Ferritin was 1800 and , having been de-ironed, he now requires a Phleb every 4 months and is in fine health.
My Ferritin at diagnosis was only around 380, but my Iron was around 30 ( 7-26 ) and my TS% was 95. So I had a series of Phlebs and the aim was to get the Ferritin down to around 20. My Hematologist was still alarmed at my TS% being always around 90-95 and ordered a couple more Phlebs. I had one and then refused any more.......taking my doctor info about iron Avidity. Technically, I don't think I 'became' Iron Avid, since my TS% is always high,
I have not had a Phleb now for 18months and I don't appear to be loading hardly at all. My ferritin now is around 60. It has dropped significantly in the past as a result of taking Zinc. I know I have a high Lead load from renovating an old house, so took Zinc to help with the Mettalothionine detox........ but my Ferritin dropped so that I had to have a whole lot of tests looking for an occult bleed. When I stopped the Zinc, my ferritin started to go up again. Zinc competes with Iron for absorption.... so I found out.
My aim now is to get my Ferritin up and keep it between 100-150. I will refuse any further Phlebs. I have no idea how to get the TS% down..... I wonder whether your B2 suggestion will help with that?
Now my Hb is 141, Hematocrit is 0.41, rbc and Platelets were always low, but have come up now to low normal on the 5MTHF.
My MCV is still 107 this week. I also have Chronic Chlamydia Pneumonia infection, and that is associated with antibodies to B12. I cannot take much more than 5mg of mB12 because I get SUCH a metal dump and feel so lousy. My adrenals are already in bad shape, and I am on Cortef 22.5 mg/day. I don't want the metal dumping to affect my kidneys.
I am taking HyB12 because that is what Rich suggested in the SMP.......