So what is "adequate".... it must be different for everyone ? If you have the metallic taste, does it mean you are taking too much, and you need to back down.
I know for sure I have a LOT of Lead on board.... so one way or another it needs to come out. But dumping it like this makes me feel AWFUl.
Hi Branston,
So what is "adequate".... it must be different for everyone
I can give you the worst answer of all, yes and no. It must be titrated to effect and in balance with other things. The balance is reached pragmatically. However, part of the answer lies in how well you body uses the folates. I know people who find 800mcg of Metafolin to be great with what they also eat. I know of people, and a lot of them apprarently were in the Deplin trials, because there they found 15 and 30mcg to be the most effective doses.
In people that have a response to b12s and folates, how often they take the folate, what they take the folate with and maybe some more unknowns that determines the exact total dose. So 4 doses a day works better than 2 doses with the same daily total.
If you can find your symptoms in the lists below then elsewhere there is a decision tree to help figure out the pathway(s). For about 95% of those experiencing "detox" find an answer here. The rest are more complicated. The metallic taste isn't something that comes and goes as quickly as the symptoms in the list below. It appears to be more of a methyltrap symptoms or somethong of the sort. BUT there may be other things that do it. An infection breaking through to the surface from a bad root canal can taste that way. Gum infections can taste that way. After these are elliminated bringing methylation up to snuff appears to get rid of it for me and many others reporting such. And for us reporting it going away with Metafolin, it was in doses over 2400mcg/day. It didn't turn on one day or turn off one day. It slowly faded away as things healed. I don't know how much was from any one cause. For me I had at least 4 causes I can think of. I had to deal with the infections first after I realized. My dentoist was able to point that out. However, my gum infections wouldn't heal until my immune system started working better which happened slowly.
All of these are flags indicating healing is occurring. Minimizing nervous system response reduces or stops healing, especially of the nervous system. Minimizing ATP response prevents normalization of biochemistry.
1 - Low potassium, almost everybody when healing starts. – often called “detox”
2 - Low folate symptoms even with small doses of Metafolin – often called “detox”
3 - Nervous system activation, everything is perceived as more intense – often called “detox”
4 – ATP activation, everything is more energetic and intense – often called “detox”
Group 1 – Hypokalemia onset. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with cyanocobalamin it is very common with methylb12 and adensosylb12 and less so with hydroxycobalamin..
IBS – Steady constipation , Nausea, Vomiting, Paralyzed Ileum, Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weakness, Abnormal heart rhythms (dysrhythmias), Increased pulse rate, Increased blood pressure, Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.
Group 2a - Both
IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipation
Group 2b – Either or both
Headache, Increased malaise, Fatigue
Group 3 - Induced and/or Paradoxical Folate deficiency or insufficiency
IBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract, increased hypersensitive responses , Skin rashes, Increased acne, Skin peeling around fingernails, Skin cracking and peeling at fingertips, Angular Cheilitis, Canker sores, Coated tongue, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptoms, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, Increase irritability, Loss of reflexes, Fevers, Old symptoms returning, Heart palpitations, Bleeding easily.
Group 4 - Hydroxycbl onset, degraded methylcbl onset, methylcbl after photolytic breakdown onset.
Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.
Group 3 symptoms, induced paradoxical folate deficiency or insufficiency are corrected quickly with titrated doses of Metafolin, methylb12 and adenosylb12. If glutathione (precursors) are the cause then larger doses of Metafolin, 7.5-15mg,or maybe more are needed. Different tissues are affected at different levels of methylfolate, it comes or goes in stages. Very strong dose proportionate characteristics are present. Serum folate levels may be high or even very high despite Metafolin responsive deficiency/insufficiency symptoms.
Group 1 symptoms respond readily to potassium. The symptoms and response to potassium may occur at a serum level of 4.3 or less.