Unfortunately, I didn't know about methylation when I started methylfolate. Jarrow's B Right changed their formula and added methylfolate. And the only methylcobalamin I was taking was the 100 mcg oral dose from the B Right. Are you saying the lack of B12 is part of the reason why I had the bad reaction?
Hi Lotus,
The problems with the methyltrap is that the symtpoms appear backwards. When the MeCbl is not where it is needed in the cell then methylfolate is flusyhed from the cell and the pr0cess breaks fo lack of methylb12, not MeCbl, give merthylfolate deficiency symptoms. Then a little bit of effective MeCbl cause b12 deficiency symptoms when the process no longer breaks at the methylfolte. This appears very contrratictory, paradoxical in fact, and confuses most everybody.
Methylfolate doesn't help a person out of a methyl-trap. MeCbl does, in sufficient quantity. In small (10mcg active absorbiton, doses it just changes the symtpoms to b12 deficiencies sysmtpoms for a few hours until depleted then back to methyltrap. It makes things look backwards.
Perhaps I can help distinguish between different level of things.
Partial methylation block creeps up on you.
Paradoxical folate deficiency, several levels, creeps up on you except when induced
MeCbl body and/or CNS creeps up on you
AdoCbl body and/or CNS partial mito blockage creeps up on you
When MeCbl gets low enough Methyl-trap (severe mfolate deficiency symptoms, CNS and/or body) - hits like a ton of bricks.
When AdoCbl/LCF gets low enough below a certain ATP generation level, sometimes muscles switch to workaround with lactic acid, prodcution, 1/6 energy. A different group of researchers from Rich (local to where I live) was looking for this situation, I had it. It hits like a ton of bricks
Methy-trap and Partial mito block (or something) together may set off each other or by the same stress; combined hits like 10 tons of bricks.
And there are likely other variations that I haven't identified yet.
The day I woke up able only to crawl to the toilet to vomit, changed my life. I had a total all system failure, total collapse. It was diagnosed as misc entero virus likely. There was a lot going on there. In 10 days I had 100 symptoms more than
before it had hit. They stayed and worsened for 17 years for me. Who here was hit with a sudden onset like a ton of bricks and looking for what happened? I think I have much of this whole thing mapped out in a way that all the pieces fit as they fit into place. What keeps it from happening easily are the many complications and paradoxical symtpoms.
Part of the puzzle is that this crash, this "tipping" appears to occur with all sorts of stresses, bacteria, virus, exhaustion, physical trauma, vaccine,
Then people don't recover well because their immune system is trashed by these breakdowns. Things get more and more out of kilter.