merylg
Senior Member
- Messages
- 841
- Location
- Sydney, NSW, Australia
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To become a member, simply click the Register button at the top right.
I'm GG as wellI am GG for rs9837484 CNTN6.
http://en.m.wikipedia.org/wiki/CNTN6
I'm AG on this oneI am GG for rs9940922 CDH13.
http://en.m.wikipedia.org/wiki/T-cadherin
I'm CTI am TT for rs9370809 JARID2.
http://en.m.wikipedia.org/wiki/JARID2
I'm AA as wellI have two copies of A for SYT14.
http://en.m.wikipedia.org/wiki/SYT14
I suspected that ME/CFS would score high on that test because it is my belief that Autism is the same illness. If anyone else wants to post their results, I've automated it and I can send you the link.
Remember that on some SNPs you have to change the risk allele letter.
How do you know which letter is the risk allele when the letters are different?I suspected that ME/CFS would score high on that test because it is my belief that Autism is the same illness. If anyone else wants to post their results, I've automated it and I can send you the link.
Remember that on some SNPs you have to change the risk allele letter.
I may be wrong, but when letters don't work, you switch the risk allele like this I think.How do you know which letter is the risk allele when the letters are different?
I suspected that ME/CFS would score high on that test because it is my belief that Autism is the same illness. If anyone else wants to post their results, I've automated it and I can send you the link.
Remember that on some SNPs you have to change the risk allele letter.
The five immunological and inflammation gene sets (iCNV-5) again ranked topmost. ...
... there is a loss of genomic copies in the interferon alphas (IFNA10, IFNA14, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA8, IFNA17) and gain of copies in the “C-C” motif chemokine ligands (CCL1, CCL11, CCL13, CCL2, CCL7, CCL8) as summarized in Table 1. Several of these chemokines have been found to be overexpressed in inflammatory diseases ... The loss of interferon alpha copies, usually implicated in the response to viral infection and another component of innate immunity, could also account for a dysregulated, secondary or compensatory response of interferons and chemokines. Several of these messengers “…are produced by neurons and glia in the adult brain, and that they can acutely influence synaptic transmission.
... The above could be suggestive of a link between in utero infections and brain development in the child. Thus, the genetic background by itself would not be enough via this view to cause a deranged developmental process which would rather only occur in the presence of relevant infections. Interferons are important in the control of viral infections via the induced expression of interferon-stimulated genes [40]. The loss of copy number in the interferon genes suggests a possible reduced expression of such genes when stimulated. Thus, a viral infection would last longer under such a genetic background. Viral infections also lead to the expression of various chemokines in the CNS [41]. Further, chemokines are also involved in brain development [27], [41]. There would therefore be a longer generation of chemokines and other cytokines that could interfere with normal brain development. Further, gain in copy number in chemokines may lead to higher levels of these chemokines and would thus exacerbate the derangement in brain development. ....
How do you know which letter is the risk allele when the letters are different?
anne_likes_red Do you know what this webinar was called or if there is a link to it? Thanks.I was at a webinar today where there were 207 participants. Methylation pathways came up a lot, and so did geneticgenie.org! Yay!