laura
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I thought this research study might be of interest to people. The entire article can be found at: http://www.kurzweilai.net/are-you-elderly-and-having-memory-or-concentration-problems
Are you elderly and having memory or concentration problems?
November 7, 2012
They might be caused by common medications used to treat insomnia, anxiety, itching or allergies, according to Dr. Cara Tannenbaum, Research Chair at the Institut universitaire de gériatrie de Montréal (IUGM, Montreal Geriatric University Institute) and Associate Professor of Medicine and Pharmacy at the University of Montreal (UdeM)....
Research summary
MEDLINE and EMBASE were searched for randomized, double-blind, placebo-controlled trials of adults without underlying central nervous system disorders who underwent detailed neuropsychological testing prior to and after oral administration of drugs affecting cholinergic, histaminergic, GABAergic or opioid receptor pathways. Seventy-eight studies were identified, reporting 162 trials testing medication from the four targeted drug classes. Two investigators independently appraised study quality and extracted relevant data on the occurrence of amnestic, non-amnestic or combined cognitive deficits induced by each drug class. Only trials using validated neuropsychological tests were included. Quality of the evidence for each drug class was assessed based on consistency of results across trials and the presence of a dose-response gradient. This research was conducted in collaboration with researchers at the University of Sydney, the University of Calgary and the University of Iowa College of Public Health.
Drugs to avoid
At KurzweilAI’s request, Dr. Tannenbaum provided the following list of the most dangerous drugs shown to affect memory (generic names):
Benzodiazepines and non-benzodiazepine sedative hypnotics:
Midazolam
Trazolam
Temazepam
Oxazepam
Lorazepam
Alprazolam
Clonazepam
Diazepam
Florazepam
Clorazepam
Zolpidem
Zopiclone
Zaleplon
Tricyclic antidepressants
Amitriptyline
Imipramine
First-generation antihistamines
Hydroxyzine
Diphenhydramine
Tripoline
Promethazine
References:
Are you elderly and having memory or concentration problems?
November 7, 2012
They might be caused by common medications used to treat insomnia, anxiety, itching or allergies, according to Dr. Cara Tannenbaum, Research Chair at the Institut universitaire de gériatrie de Montréal (IUGM, Montreal Geriatric University Institute) and Associate Professor of Medicine and Pharmacy at the University of Montreal (UdeM)....
Research summary
MEDLINE and EMBASE were searched for randomized, double-blind, placebo-controlled trials of adults without underlying central nervous system disorders who underwent detailed neuropsychological testing prior to and after oral administration of drugs affecting cholinergic, histaminergic, GABAergic or opioid receptor pathways. Seventy-eight studies were identified, reporting 162 trials testing medication from the four targeted drug classes. Two investigators independently appraised study quality and extracted relevant data on the occurrence of amnestic, non-amnestic or combined cognitive deficits induced by each drug class. Only trials using validated neuropsychological tests were included. Quality of the evidence for each drug class was assessed based on consistency of results across trials and the presence of a dose-response gradient. This research was conducted in collaboration with researchers at the University of Sydney, the University of Calgary and the University of Iowa College of Public Health.
Drugs to avoid
At KurzweilAI’s request, Dr. Tannenbaum provided the following list of the most dangerous drugs shown to affect memory (generic names):
Benzodiazepines and non-benzodiazepine sedative hypnotics:
Midazolam
Trazolam
Temazepam
Oxazepam
Lorazepam
Alprazolam
Clonazepam
Diazepam
Florazepam
Clorazepam
Zolpidem
Zopiclone
Zaleplon
Tricyclic antidepressants
Amitriptyline
Imipramine
First-generation antihistamines
Hydroxyzine
Diphenhydramine
Tripoline
Promethazine
References: