MTHFS defect (folinic acid intolerance) - request for genetic data

[Lynn_M]

Thanks for your note I.R. Baboon. I didn't see it until too late, but maybe it will help someone else, or me if I need to repost.

 

[nandixon]

Thanks Lynn. 23andMe does (presently) include Yasko's SHMT1 gene. Try followng this link to obtain it :
https://www.23andme.com/you/explorer/snp/?snp_name=rs1979277
I'll add your MTHFS results to post #13 above in a little while.

 

[Lynn_M]

Thanks Lynn. 23andMe does (presently) include Yasko's SHMT1 gene. Try followng this link to obtain it :
https://www.23andme.com/you/explorer/snp/?snp_name=rs1979277
I'll add your MTHFS results to post #13 above in a little while.

Okay, my SHMT1 rs1979277 is AG.

 

[merylg]

A or G
GG

A or C
CC

C or T rs8923
TT

C or T
TT

A or C
AA

A or G
AA

C or T
TT

A or G
AA

C or T
CC

A or C
AA

A or G
GG

A or C
AA

C or T
CC

A or G
GG

G or T
TT

A or G
AA

C or T
TT

A or C
AA

A or G
GG

A or C
CC

C or T
TT

A or C
AA

A or G
AA

C or T
CC

SHMT1
rs1979277 A or G GG

 

[merylg]

I seem to tolerate Folinic Acid (as Calcium Folinate) OK. I am trying it again, but NOT as part of any methylation protocol....(so no B12 supplements & no methylfolate, as I don't tolerate these in any doses). Been 5 days & so far no apparent side effects.

 

[nandixon]

Thanks Meryl! I've added you below. Your SHMT1 is normal, so you'd be less inclined to have a problem with folinic acid, in theory (I think). So that's consistent. It's interesting that you have three (3) results no one else does, so far.

Rich=1, nandixon=2, Gestalt=3, Anne=4, caledonia=5, geesiddiqui=6, I.R.Baboon=7, Lynn_M=8, merylg=9

MTHFS 1 2 3 4 5 6 7 8 9
rs8923 CT (TT) (TT) (TT) (TT) (TT) (TT) (CT) (TT)
rs2733103 CC (CT) (CC) (CT) (CT) (CT) (CT) (CC) (TT)
rs16971427 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) x
rs655473 AA (AA) (AA) (AA) (AA) (AG) (AA) (AA) (AA)
rs17284990 TT (CT) (CT) (TT) (TT) (TT) (TT) (CT) (TT)
rs16971450 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) x
rs6495446 CT (CC) (CC) (CC) (CC) (CC) (CC) (CT) (CC) +++
rs7177659 CC (AA) (AA) (AA) (AC) (AA) (AC) (AA) (AA) ***
rs6495449 GG (GG) (GG) (AG) (GG) (GG) (GG) (GG) (GG)
rs17285431 AC (AA) (AA) (AC) (AA) (AA) (AC) (AA) (AA)
rs6495451 CT (CC) (CT) (CT) (CC) (CC) (CT) (CT) (CC)
rs2586154 GG (AG) (AG) (GG) (GG) (AG) (GG) (GG) (GG)
rs12899781 GT (TT) (TT) (GT) (TT) (TT) (GT) (TT) (TT)
rs16971478 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) x
rs2586153 CC (CT) (CC) (CT) (CT) (CT) (CC) (CC) (TT)
rs2562744 AA (AC) (CC) (AC) (AA) (AA) (AA) (AC) (AA)
rs2733106 AA (AG) (AA) (AG) (AG) (AG) (AA) (AA) (GG)
rs12438477 CC (CC) (AC) (AC) (CC) (CC) (CC) (AC) (CC)
rs12898642 CT (TT) (CT) (CT) (TT) (TT) (CT) (CT) (TT)
rs2586182 AA (AC) (AC) (AA) (AA) (AA) (AA) (AA) (AA)
rs2733088 AG (AG) (GG) (AG) (AA) (AA) (AG) (AG) (AA)
rs12440798 CC (CC) (CT) (CC) (CC) (CC) (CC) (CT) (CC)

My two additional MTHFS results (that Rich doesn't have):
2 4 5 6 7 8 9
rs685487 (GG) (AG) (AG) (AG) (AG) (AG) (GG)
rs8033649 (CC) (CC) (CC) (CC) (CC) (CC) (CC)

*** The AC variant of rs7177659 has less cardiovascular disease risk compared to AA and CC, therefore the homozygous states may increase/decrease enzyme activity (free full text not available: http://www.ncbi.nlm.nih.gov/pubmed/22649255/)

+++ Each T allele for rs6495446 reduces chronic kidney disease risk (http://www.biomedcentral.com/1471-2350/9/49/) This SNP is probably paired with rs8923.

 

[merylg]

Hi nandixon, after a week on Folinic Acid I think I am becoming intolerant. Today I feel dehydrated & have weak muscles all over. (It's always hard to say if a symptom is the illness or a reaction) I'm going to stop taking the Folinic Acid.

 

[triffid113]

Well I have my Yasko gene map and I am supposed to take folinic acid according to my doctor and it does not bother me. I do not know how to convert a Yasko panel to a 23andme reportout. I do not have anywhere near the exhaustion issues many of you have but I do have that PEM thing. My family (elders) have seemed to have chronic fatigue most of their lives however undiagnosed due to blaming it on diabetes (yet I have ALWAYS been aware that diabetes does not necessarily make one fatigued and I know diabetics who join cycling marathons etc regularly). I do not know how you distinguish someone who has ME from someone who has the genes for it but beat it through supplements (in other words I seem to have all the bad genes y'all have times 3). So I don't know if you want to look at my genes but I take Thorne Basic B which has a bit of folinic acid in it 2x/day and that works for me.

I was a very sickly kid despite my mother becoming an armchair nutritionist on account of me. I am still very sickly but now I know what to take when to ward most stuff off. As long as I take my vitamins I am simply a bit clumsy but not unfunctional, have a bit of PEM but am on par with others who do not take vitamins or eat too well. (I often think what powerhouses THEY could be if they would just have a care!)

Triff

 

[roxie60]

Hope I can find this thread when I get my 23andme results back. Nice potentially useful info.

Someone also created a spreadsheet that listed everyones methylation pathways results which was interesting to see so many with similar values (high/low). Rivka was on the sheet, I wonder if that spreadsheet is still being kept up to date.

 

[roxie60]

With the 23andMe price reduction I expect in about 3-4 weeks there will be a lot more info to add to this list, might have to make a spreadsheet.

 

[snowathlete]

OK, here are my results added.

Rich=1, nandixon=2, Gestalt=3, Anne=4, caledonia=5, geesiddiqui=6, I.R.Baboon=7, Lynn_M=8, merylg=9 snowathlete=10

MTHFS 1 2 3 4 5 6 7 8 9 10
rs8923 CT (TT) (TT) (TT) (TT) (TT) (TT) (CT) (TT) (TT)
rs2733103 CC (CT) (CC) (CT) (CT) (CT) (CT) (CC) (TT) (CC)
rs16971427 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) x
rs655473 AA (AA) (AA) (AA) (AA) (AG) (AA) (AA) (AA) (AA)
rs17284990 TT (CT) (CT) (TT) (TT) (TT) (TT) (CT) (TT) (TT)
rs16971450 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AG) x
rs6495446 CT (CC) (CC) (CC) (CC) (CC) (CC) (CT) (CC) (CT) +++
rs7177659 CC (AA) (AA) (AA) (AC) (AA) (AC) (AA) (AA) (CC) ***
rs6495449 GG (GG) (GG) (AG) (GG) (GG) (GG) (GG) (GG) (AG)
rs17285431 AC (AA) (AA) (AC) (AA) (AA) (AC) (AA) (AA) (AC)
rs6495451 CT (CC) (CT) (CT) (CC) (CC) (CT) (CT) (CC) (TT)
rs2586154 GG (AG) (AG) (GG) (GG) (AG) (GG) (GG) (GG) (GG)
rs12899781 GT (TT) (TT) (GT) (TT) (TT) (GT) (TT) (TT) (GT)
rs16971478 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) x
rs2586153 CC (CT) (CC) (CT) (CT) (CT) (CC) (CC) (TT) (CC)
rs2562744 AA (AC) (CC) (AC) (AA) (AA) (AA) (AC) (AA) (CC)
rs2733106 AA (AG) (AA) (AG) (AG) (AG) (AA) (AA) (GG) (AA)
rs12438477 CC (CC) (AC) (AC) (CC) (CC) (CC) (AC) (CC) (AA)
rs12898642 CT (TT) (CT) (CT) (TT) (TT) (CT) (CT) (TT) (CC)
rs2586182 AA (AC) (AC) (AA) (AA) (AA) (AA) (AA) (AA) (AA)
rs2733088 AG (AG) (GG) (AG) (AA) (AA) (AG) (AG) (AA) (GG)
rs12440798 CC (CC) (CT) (CC) (CC) (CC) (CC) (CT) (CC) (CC)

My two additional MTHFS results (that Rich doesn't have):
2 4 5 6 7 8 9 10
rs685487 (GG) (AG) (AG) (AG) (AG) (AG) (GG) (AA)
rs8033649 (CC) (CC) (CC) (CC) (CC) (CC) (CC) (CC)

*** The AC variant of rs7177659 has less cardiovascular disease risk compared to AA and CC, therefore the homozygous states may increase/decrease enzyme activity (free full text not available: http://www.ncbi.nlm.nih.gov/pubmed/22649255/)

+++ Each T allele for rs6495446 reduces chronic kidney disease risk (http://www.biomedcentral.com/1471-2350/9/49/) This SNP is probably paired with rs8923.

I dont know how significant it is that five of my results are unique: TT at rs6495451, AA at rs12438477, CC at rs12898642 and AG at rs16971450, AA at rs685487. Anyone know what that means?

 

[maddietod]

MTHFS, ST20-MTHFS 80136129 rs685487 A or G AG
MTHFS, ST20-MTHFS 80136288 rs8033649 A or C CC
MTHFS, ST20-MTHFS 80137560 rs8923 C or T TT
MTHFS, ST20-MTHFS 80138571 rs2733103 C or T CT
MTHFS, ST20-MTHFS 80138745 rs16971427 A or C AA
MTHFS, ST20-MTHFS 80141997 rs655473 A or G AA
MTHFS, ST20-MTHFS 80144197 rs17284990 C or T TT
MTHFS, ST20-MTHFS 80154571 rs16971450 A or G AA
MTHFS, ST20-MTHFS 80154982 rs6495446 C or T CC
MTHFS, ST20-MTHFS 80158042 rs7177659 A or C AC
MTHFS, ST20-MTHFS 80158159 rs6495449 A or G GG
MTHFS, ST20-MTHFS 80162265 rs17285431 A or C AA
MTHFS, ST20-MTHFS 80164053 rs6495451 C or T CT
MTHFS, ST20-MTHFS 80165368 rs2586154 A or G GG
MTHFS, ST20-MTHFS 80168282 rs12899781 G or T TT
MTHFS, ST20-MTHFS 80171971 rs16971478 A or G AA
MTHFS, ST20-MTHFS 80172133 rs2586153 C or T CC
MTHFS, ST20-MTHFS 80174388 rs2562744 A or C AC
MTHFS, ST20-MTHFS 80177687 rs2733106 A or G AA
MTHFS, ST20-MTHFS 80178283 rs12438477 A or C AC
MTHFS, ST20-MTHFS 80182050 rs12898642 C or T CT
MTHFS, ST20-MTHFS 80183766 rs2586182 A or C AA
MTHFS, ST20-MTHFS 80184657 rs2733088 A or G AG
MTHFS, ST20-MTHFS 80186340 rs12440798 C or T
CT

 

[roxie60]

OK, here are my results added. I do not know my status for folinic/folic acid tolerance.

Rich=1, nandixon=2, Gestalt=3, Anne=4, caledonia=5, geesiddiqui=6, I.R.Baboon=7, Lynn_M=8, merylg=9 snowathlete=10, roxie60=11

MTHFS 1 2 3 4 5 6 7 8 9 10 11
rs8923 CT (TT) (TT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (TT)
rs2733103 CC (CT) (CC) (CT) (CT) (CT) (CT) (CC) (TT) (CC) (CC)
rs16971427 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x
rs655473 AA (AA) (AA) (AA) (AA) (AG) (AA) (AA) (AA) (AA) (AA)
rs17284990 TT (CT) (CT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (CT)
rs16971450 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AG) (AG) x
rs6495446 CT (CC) (CC) (CC) (CC) (CC) (CC) (CT) (CC) (CT)(CT) +++
rs7177659 CC (AA) (AA) (AA) (AC) (AA) (AC) (AA) (AA) (CC) (AC)***
rs6495449 GG (GG) (GG) (AG) (GG) (GG) (GG) (GG) (GG) (AG) (GG)
rs17285431 AC (AA) (AA) (AC) (AA) (AA) (AC) (AA) (AA) (AC)(AA)
rs6495451 CT (CC) (CT) (CT) (CC) (CC) (CT) (CT) (CC) (TT) (CT)
rs2586154 GG (AG) (AG) (GG) (GG) (AG) (GG) (GG) (GG) (GG) (AG)
rs12899781 GT (TT) (TT) (GT) (TT) (TT) (GT) (TT) (TT) (GT)(TT)
rs16971478 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x
rs2586153 CC (CT) (CC) (CT) (CT) (CT) (CC) (CC) (TT) (CC) (CC)
rs2562744 AA (AC) (CC) (AC) (AA) (AA) (AA) (AC) (AA) (CC)(CC)
rs2733106 AA (AG) (AA) (AG) (AG) (AG) (AA) (AA) (GG) (AA)(AA)
rs12438477 CC (CC) (AC) (AC) (CC) (CC) (CC) (AC) (CC) (AA)(AC)
rs12898642 CT (TT) (CT) (CT) (TT) (TT) (CT) (CT) (TT) (CC)(CT)
rs2586182 AA (AC) (AC) (AA) (AA) (AA) (AA) (AA) (AA) (AA)(AC)
rs2733088 AG (AG) (GG) (AG) (AA) (AA) (AG) (AG) (AA) (GG)(GG)
rs12440798 CC (CC) (CT) (CC) (CC) (CC) (CC) (CT) (CC) (CC)(CC)

My two additional MTHFS results (that Rich doesn't have):
2 4 5 6 7 8 9 10 11
rs685487 (GG) (AG) (AG) (AG) (AG) (AG) (GG) (AA)(AG)
rs8033649 (CC) (CC) (CC) (CC) (CC) (CC) (CC) (CC)(CC)

*** The AC variant of rs7177659 has less cardiovascular disease risk compared to AA and CC, therefore the homozygous states may increase/decrease enzyme activity (free full text not available: http://www.ncbi.nlm.nih.gov/pubmed/22649255/)

+++ Each T allele for rs6495446 reduces chronic kidney disease risk (http://www.biomedcentral.com/1471-2350/9/49/) This SNP is probably paired with rs8923.

 

[drex13]

Here are my results, added on to the end of the others, for what it's worth. I had originally emailed these to Rich, way back when. Also my SHMT1 result is GG, so all good there.

Rich=1, nandixon=2, Gestalt=3, Anne=4, caledonia=5, geesiddiqui=6, I.R.Baboon=7, Lynn_M=8, merylg=9 snowathlete=10, roxie60=11, drex13=12

MTHFS 1 2 3 4 5 6 7 8 9 10 11
rs8923 CT (TT) (TT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (TT) (CT)
rs2733103 CC (CT) (CC) (CT) (CT) (CT) (CT) (CC) (TT) (CC) (CC) (CT)
rs16971427 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x (AA)
rs655473 AA (AA) (AA) (AA) (AA) (AG) (AA) (AA) (AA) (AA) (AA) (AA)
rs17284990 TT (CT) (CT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (CT) (TT)
rs16971450 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AG) (AG) x (AA)
rs6495446 CT (CC) (CC) (CC) (CC) (CC) (CC) (CT) (CC) (CT)(CT) +++ (CT)
rs7177659 CC (AA) (AA) (AA) (AC) (AA) (AC) (AA) (AA) (CC) (AC)*** (AC)
rs6495449 GG (GG) (GG) (AG) (GG) (GG) (GG) (GG) (GG) (AG) (GG) (GG)
rs17285431 AC (AA) (AA) (AC) (AA) (AA) (AC) (AA) (AA) (AC)(AA) (AC)
rs6495451 CT (CC) (CT) (CT) (CC) (CC) (CT) (CT) (CC) (TT) (CT) (CT)
rs2586154 GG (AG) (AG) (GG) (GG) (AG) (GG) (GG) (GG) (GG) (AG) (GG)
rs12899781 GT (TT) (TT) (GT) (TT) (TT) (GT) (TT) (TT) (GT)(TT) (GT)
rs16971478 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x (AA)
rs2586153 CC (CT) (CC) (CT) (CT) (CT) (CC) (CC) (TT) (CC) (CC) (CT)
rs2562744 AA (AC) (CC) (AC) (AA) (AA) (AA) (AC) (AA) (CC)(CC) (AA)
rs2733106 AA (AG) (AA) (AG) (AG) (AG) (AA) (AA) (GG) (AA)(AA) (AG)
rs12438477 CC (CC) (AC) (AC) (CC) (CC) (CC) (AC) (CC) (AA)(AC) (CC)
rs12898642 CT (TT) (CT) (CT) (TT) (TT) (CT) (CT) (TT) (CC)(CT) (CT)
rs2586182 AA (AC) (AC) (AA) (AA) (AA) (AA) (AA) (AA) (AA)(AC) (AA)
rs2733088 AG (AG) (GG) (AG) (AA) (AA) (AG) (AG) (AA) (GG)(GG) (AG)
rs12440798 CC (CC) (CT) (CC) (CC) (CC) (CC) (CT) (CC) (CC)(CC) (CC)

 

[Lotus97]

I know very little about SNPs because I've never been tested, but since I'm learning about methylation and giving advice to others I decided to start learning some. I thought it was the MTHFR SNP where folinic acid and folic acid blocked methylfolate, but then I saw Rich's thread about MTHFS regarding Freddd's situation with folinic acid.
http://forums.phoenixrising.me/index.php?threads/attention-freddd-mthfs-deficiency.11524/

I have a few questions about this:

• So what exactly is the difference between MTHFR and MTHFS in regards to folic acid and/or folinic acid blocking methylfolate?
• With the MTHFR SNP, is it just that they have converting folinic acid and folic acid into methylfolate and not that they block methylfolate?
• And is done by blocking the DHFR enzyme or is there another mechanism involved in this process?
• Also, about what percentage of the people here have a problem with folic acid and/or folinic acid? Based on the results of his 2009 methylation study which included a small amount of both folic and folinic acid Rich seemed to think that a small amount of both wouldn't cause problems for most of the people here, but I would like to know others' opinions besides Rich's on this.

Also, dbkita seemed to think that the folinic acid in plant folate was different than supplemental folinic acid (I assume he menas more than just vegetables such as beans, grains, fruit, nuts, and seeds). I'm curious what other people think of this theory as far as a distinction between plant folate and supplemental folinic acid or folic acid.

Folinic acid is a 5-formyl derivative of THF. The folates in vegetables are not folinic or folic acid (a fully oxidized synthetic folate, i.e. pteroylmonoglutamic acid). This is a notorious misconception in the research community. The folates in food are metabolites of THF packed within polyglutamates. In the intestinal lumen these polyglutmate dietary forms are broken down into monoglutamate variants which can then be converted to DHF and then THF by their respective enzymes. The DHFR enzyme is not present in humans for the synthetic folic acid it is present for processing dietary folates. Folinic acid is readily converted to 5,10 methylene THF without use of DHFR. That being said dietary folates parallel more with folic acid than with folinic acid with one crucial difference ... they can be processed in the intestinal lumen and the liver. Folic acid (I am pretty sure) being fully oxidized must be converted in the liver.

I don't think this changes the fact that high dietary folates could be an issue for some people who can not make use of them, have intestinal wall damage, or critical needs for 5mthf but let's be honest while maybe garden feasts are not a good idea, it is not wise probably to eschew vegetables entirely as a general rule.

 

[Sea]

Rich=1, nandixon=2, Gestalt=3, Anne=4, caledonia=5, geesiddiqui=6, I.R.Baboon=7, Lynn_M=8, merylg=9 snowathlete=10, roxie60=11, drex13=12, Sea=13

MTHFS 1 2 3 4 5 6 7 8 9 10 11
rs8923 CT (TT) (TT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (TT) (CT) (TT)
rs2733103 CC (CT) (CC) (CT) (CT) (CT) (CT) (CC) (TT) (CC) (CC) (CT) (CC)
rs16971427 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x (AA) (AA)
rs655473 AA (AA) (AA) (AA) (AA) (AG) (AA) (AA) (AA) (AA) (AA) (AA) (AA)
rs17284990 TT (CT) (CT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (CT) (TT) (TT)
rs16971450 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AG) (AG) x (AA) (AA)
rs6495446 CT (CC) (CC) (CC) (CC) (CC) (CC) (CT) (CC) (CT)(CT) +++ (CT) (CC)
rs7177659 CC (AA) (AA) (AA) (AC) (AA) (AC) (AA) (AA) (CC) (AC)*** (AC) (CC)
rs6495449 GG (GG) (GG) (AG) (GG) (GG) (GG) (GG) (GG) (AG) (GG) (GG) (GG)
rs17285431 AC (AA) (AA) (AC) (AA) (AA) (AC) (AA) (AA) (AC)(AA) (AC) (AA)
rs6495451 CT (CC) (CT) (CT) (CC) (CC) (CT) (CT) (CC) (TT) (CT) (CT) (CC)
rs2586154 GG (AG) (AG) (GG) (GG) (AG) (GG) (GG) (GG) (GG) (AG) (GG) (GG)
rs12899781 GT (TT) (TT) (GT) (TT) (TT) (GT) (TT) (TT) (GT)(TT) (GT) (TT)
rs16971478 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x (AA) (AA)
rs2586153 CC (CT) (CC) (CT) (CT) (CT) (CC) (CC) (TT) (CC) (CC) (CT) (CC)
rs2562744 AA (AC) (CC) (AC) (AA) (AA) (AA) (AC) (AA) (CC)(CC) (AA) (AA)
rs2733106 AA (AG) (AA) (AG) (AG) (AG) (AA) (AA) (GG) (AA)(AA) (AG) (AA)
rs12438477 CC (CC) (AC) (AC) (CC) (CC) (CC) (AC) (CC) (AA)(AC) (CC) (CC)
rs12898642 CT (TT) (CT) (CT) (TT) (TT) (CT) (CT) (TT) (CC)(CT) (CT) (TT)
rs2586182 AA (AC) (AC) (AA) (AA) (AA) (AA) (AA) (AA) (AA)(AC) (AA) (AA)
rs2733088 AG (AG) (GG) (AG) (AA) (AA) (AG) (AG) (AA) (GG)(GG) (AG) (AA)
rs12440798 CC (CC) (CT) (CC) (CC) (CC) (CC) (CT) (CC) (CC)(CC) (CC) (CC)

My SHMT1 rs1979277 is GG

 

[Creekee]

Rich=1, nandixon=2, Gestalt=3, Anne=4, caledonia=5, geesiddiqui=6, I.R.Baboon=7, Lynn_M=8, merylg=9 snowathlete=10, roxie60=11, drex13=12, Sea=13, Creekee=14


rs8923 CT (TT) (TT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (TT) (CT) (TT) (CT)
rs2733103 CC (CT) (CC) (CT) (CT) (CT) (CT) (CC) (TT) (CC) (CC) (CT) (CC) (CC)
rs16971427 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x (AA) (AA) (AA)
rs655473 AA (AA) (AA) (AA) (AA) (AG) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)
rs17284990 TT (CT) (CT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (CT) (TT) (TT) (TT)
rs16971450 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AG) (AG) x (AA) (AA) (AG)
rs6495446 CT (CC) (CC) (CC) (CC) (CC) (CC) (CT) (CC) (CT)(CT) +++ (CT) (CC) (TT)
rs7177659 CC (AA) (AA) (AA) (AC) (AA) (AC) (AA) (AA) (CC) (AC)*** (AC) (CC) (AC)
rs6495449 GG (GG) (GG) (AG) (GG) (GG) (GG) (GG) (GG) (AG) (GG) (GG) (GG) (GG)
rs17285431 AC (AA) (AA) (AC) (AA) (AA) (AC) (AA) (AA) (AC)(AA) (AC) (AA) (AA)
rs6495451 CT (CC) (CT) (CT) (CC) (CC) (CT) (CT) (CC) (TT) (CT) (CT) (CC) (TT)
rs2586154 GG (AG) (AG) (GG) (GG) (AG) (GG) (GG) (GG) (GG) (AG) (GG) (GG) (GG)
rs12899781 GT (TT) (TT) (GT) (TT) (TT) (GT) (TT) (TT) (GT)(TT) (GT) (TT) (TT)
rs16971478 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x (AA) (AA) (AA)
rs2586153 CC (CT) (CC) (CT) (CT) (CT) (CC) (CC) (TT) (CC) (CC) (CT) (CC) (CC)
rs2562744 AA (AC) (CC) (AC) (AA) (AA) (AA) (AC) (AA) (CC)(CC) (AA) (AA) (CC)
rs2733106 AA (AG) (AA) (AG) (AG) (AG) (AA) (AA) (GG) (AA)(AA) (AG) (AA) (AA)
rs12438477 CC (CC) (AC) (AC) (CC) (CC) (CC) (AC) (CC) (AA)(AC) (CC) (CC) (AA)
rs12898642 CT (TT) (CT) (CT) (TT) (TT) (CT) (CT) (TT) (CC)(CT) (CT) (TT) (CC)
rs2586182 AA (AC) (AC) (AA) (AA) (AA) (AA) (AA) (AA) (AA)(AC) (AA) (AA) (AA)
rs2733088 AG (AG) (GG) (AG) (AA) (AA) (AG) (AG) (AA) (GG)(GG) (AG) (AA) (GG)
rs12440798 CC (CC) (CT) (CC) (CC) (CC) (CC) (CT) (CC) (CC)(CC) (CC) (CC) (CT)

MTHFS 2 4 5 6 7 8 9 10 11 14
rs685487 (GG) (AG) (AG) (AG) (AG) (AG) (GG) (AA)(AG) (AA)
rs8033649 (CC) (CC) (CC) (CC) (CC) (CC) (CC) (CC)(CC) (CC)

My SHMT C1420T rs1979277 is AG

I don't think folinic acid is a problem for me, but it's early days.

Thank you for organizing this one!

 

[Lotus97]

Hi nandixon, after a week on Folinic Acid I think I am becoming intolerant. Today I feel dehydrated & have weak muscles all over. (It's always hard to say if a symptom is the illness or a reaction) I'm going to stop taking the Folinic Acid.

Did you ever figure out what was going on? I'm not too familiar with folate deficiency symptoms. Those do sound like symptoms of low potassium though. I don't know if folinic acid alone is enough to cause low potassium though since you say you weren't taking any other methylation supplements. If you don't have a problem with folinic acid though you would be converting some to methylfolate which the only reason why I mention it even though it seems unlikely.

 

[musicfreak]

Hi Nandixon. Here are my results:

MTHFS, ST20-MTHFS 80136129 rs685487 A or G AG
MTHFS, ST20-MTHFS 80136288 rs8033649 A or C CC
MTHFS, ST20-MTHFS 80137560 rs8923 C or T TT
MTHFS, ST20-MTHFS 80138571 rs2733103 C or T CC
MTHFS, ST20-MTHFS 80138745 rs16971427 A or C AA
MTHFS, ST20-MTHFS 80141997 rs655473 A or G AA
MTHFS, ST20-MTHFS 80144197 rs17284990 C or T CT
MTHFS, ST20-MTHFS 80154571 rs16971450 A or G AA
MTHFS, ST20-MTHFS 80154982 rs6495446 C or T CC
MTHFS, ST20-MTHFS 80158042 rs7177659 A or C AC
MTHFS, ST20-MTHFS 80158159 rs6495449 A or G GG
MTHFS, ST20-MTHFS 80162265 rs17285431 A or C AA
MTHFS, ST20-MTHFS 80164053 rs6495451 C or T CC
MTHFS, ST20-MTHFS 80165368 rs2586154 A or G AG
MTHFS, ST20-MTHFS 80168282 rs12899781 G or T TT
MTHFS, ST20-MTHFS 80171971 rs16971478 A or G AA
MTHFS, ST20-MTHFS 80172133 rs2586153 C or T CC
MTHFS, ST20-MTHFS 80174388 rs2562744 A or C AC
MTHFS, ST20-MTHFS 80177687 rs2733106 A or G AA
MTHFS, ST20-MTHFS 80178283 rs12438477 A or C CC
MTHFS, ST20-MTHFS 80182050 rs12898642 C or T TT
MTHFS, ST20-MTHFS 80183766 rs2586182 A or C AC
MTHFS, ST20-MTHFS 80184657 rs2733088 A or G AG
MTHFS, ST20-MTHFS 80186340 rs12440798 C or T CC

SHMT1 C1420T -/- GG

 

[Paula Thomas]

Not sure if anyone is still looking into this but thought I'd add mine in. I don't know if I really have any negative affects from Folic Acid. I've never taken it in high doses but my serum folate levels have always been high which makes me think I have a hard time converting it.

Rich=1, nandixon=2, Gestalt=3, Anne=4, caledonia=5, geesiddiqui=6, I.R.Baboon=7, Lynn_M=8, merylg=9 snowathlete=10, roxie60=11, drex13=12, Sea=13, Creekee=14, Paula=15

rs8923 CT (TT) (TT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (TT) (CT) (TT) (CT) (CT)
rs2733103 CC (CT) (CC) (CT) (CT) (CT) (CT) (CC) (TT) (CC) (CC) (CT) (CC) (CC) (CT)
rs16971427 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x (AA) (AA) (AA) (AA)
rs655473 AA (AA) (AA) (AA) (AA) (AG) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)
rs17284990 TT (CT) (CT) (TT) (TT) (TT) (TT) (CT) (TT) (TT) (CT) (TT) (TT) (TT) (TT)
rs16971450 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AG) (AG) x (AA) (AA) (AG) (AG)
rs6495446 CT (CC) (CC) (CC) (CC) (CC) (CC) (CT) (CC) (CT)(CT) +++ (CT) (CC) (TT) (CT)
rs7177659 CC (AA) (AA) (AA) (AC) (AA) (AC) (AA) (AA) (CC) (AC)*** (AC) (CC) (AC) (CC)
rs6495449 GG (GG) (GG) (AG) (GG) (GG) (GG) (GG) (GG) (AG) (GG) (GG) (GG) (GG) (GG)
rs17285431 AC (AA) (AA) (AC) (AA) (AA) (AC) (AA) (AA) (AC)(AA) (AC) (AA) (AA) (AA)
rs6495451 CT (CC) (CT) (CT) (CC) (CC) (CT) (CT) (CC) (TT) (CT) (CT) (CC) (TT) (TT)
rs2586154 GG (AG) (AG) (GG) (GG) (AG) (GG) (GG) (GG) (GG) (AG) (GG) (GG) (GG) (GG)
rs12899781 GT (TT) (TT) (GT) (TT) (TT) (GT) (TT) (TT) (GT)(TT) (GT) (TT) (TT) (TT)
rs16971478 AA (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA) (AA)x (AA) (AA) (AA) (AG)
rs2586153 CC (CT) (CC) (CT) (CT) (CT) (CC) (CC) (TT) (CC) (CC) (CT) (CC) (CC) (CC)
rs2562744 AA (AC) (CC) (AC) (AA) (AA) (AA) (AC) (AA) (CC)(CC) (AA) (AA) (CC) (CC)
rs2733106 AA (AG) (AA) (AG) (AG) (AG) (AA) (AA) (GG) (AA)(AA) (AG) (AA) (AA) (AA)
rs12438477 CC (CC) (AC) (AC) (CC) (CC) (CC) (AC) (CC) (AA)(AC) (CC) (CC) (AA) (AA)
rs12898642 CT (TT) (CT) (CT) (TT) (TT) (CT) (CT) (TT) (CC)(CT) (CT) (TT) (CC) (CC)
rs2586182 AA (AC) (AC) (AA) (AA) (AA) (AA) (AA) (AA) (AA)(AC) (AA) (AA) (AA) (AA)
rs2733088 AG (AG) (GG) (AG) (AA) (AA) (AG) (AG) (AA) (GG)(GG) (AG) (AA) (GG) (GG)
rs12440798 CC (CC) (CT) (CC) (CC) (CC) (CC) (CT) (CC) (CC)(CC) (CC) (CC) (CT) (CT)

MTHFS 2 4 5 6 7 8 9 10 11 14 15
rs685487 (GG) (AG) (AG) (AG) (AG) (AG) (GG) (AA)(AG) (AA) (AG)
rs8033649 (CC) (CC) (CC) (CC) (CC) (CC) (CC) (CC)(CC) (CC) (CC)

My SHMT C1420T rs1979277 is GG