other B cell depletors, far future

[Sherlock]

Clin Immunol. 2012 Mar;142(3):237-42. Epub 2012 Jan 5.
Syk inhibition with fostamatinib leads to transitional B lymphocyte depletion.

http://www.ncbi.nlm.nih.gov/pubmed/22284392

...has produced significant efficacy in lymphoid malignancies and autoimmune conditions... These findings provide insight into the mechanism of action of B cell receptor inhibition in autoimmune disease... this rapidly growing class of novel agents.

Syk = spleen tyrosine kinase

Now just for fun, imagine your own clinical trial.

Syk inhibitors for sale:
http://www.selleckbio.com/syk-inhibitors.html?gclid=CIiHgYLjtbICFcne4AodYSoAYQ

Offhand, it seems that anybody with a credit card can buy it?


This trial uses up to 200mg per day: http://www.clinicaltrials.gov/ct2/show/NCT01242514?term=oskira&rank=1

Fostamatinib for sale:
http://www.selleckbio.com/R935788-Fostamatinib-disodium-S2206.html

So 200mg = a mere $5000

 

[taniaaust1]

a mere $5000.. and just maybe I'll win the lotto one day.

 

[Sherlock]

a mere $5000.. and just maybe I'll win the lotto one day.

I looked for a price on the lab mice to go with the drug. Wow, there must be close to 100 strains under Immunology and Inflammation Research alone. It seems like fairly big business.

Strain listing for Immunology and Inflammation Research

The links below offer the most recent strain information for Immunology Models, including current ordering and pricing information:

http://jaxmice.jax.org/list/rax10.html