Ember
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In a comment on the Research1st To PEM or not to PEM post, Frank Twisk writes, It is time to leave the CFS label and 'fatigue' behind us and to make a clear distinction between ME patients (those with PEM and e.g. cognitive impairment) and 'CFS' patients (those without PEM).
Here's his full comment:
It seems that the intent here is to modify Fukuda rather than to support using either the CCC or the ME-ICC.
Here's his full comment:
Frank Twisk 28. Apr, 2012 at 6:08 am #
Oxidative stress is just one of the many abormalities induced/intensified by (mental and physical) exertion that could account for PEM. As substantiated in Twisk and Maes (2009):
Exertion induces post-exertional malaise with a decreased physical performance/aerobic capacity, increased muscoskeletal pain, neurocognitive impairment, fatigue, and weakness, and a long lasting recovery time.
This can be explained by findings that exertion may amplify pre-existing pathophysiological abnormalities underpinning ME/CFS, such as inflammation, immune dysfunction, oxidative and nitrosative stress, channelopathy, defective stress response mechanisms and a hypoactive hypothalamic-pituitary-adrenal (HPA) axis.
Using Fukuda et al. (1994) criteria and PEM, fatigue, and a subjective feeling of infection as discriminatory symptoms we recently established that ME, CFS (Fukuda/not-ME) and CF are distinct diagnostic categories.
ME patients have significantly higher scores on concentration difficulties and a subjective experience of infection, and higher levels of IL-1, TNF?, and neopterin than patients with CFS.
Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: Results of supervised learning techniques applied on clinical and inflammatory data.
Psychiatry Res. 2012 Apr 20. doi: 10.1016/j.psychres.2012.03.031.
Maes M, Twisk FNM, Johnson C.
http://www.sciencedirect.com/science/article/pii/S0165178112001400
It is time to leave the CFS label and fatigue behind us and to make a clear distinction between ME patients (those with PEM and e.g. cognitive impairment) and CFS patients (those without PEM).
http://www.research1st.com/2012/04/27/pem-case-def/
It seems that the intent here is to modify Fukuda rather than to support using either the CCC or the ME-ICC.