Hi Charles,
I'll answer your question, though I'm not sure you'll like it- my start up reaction (to Rich's SMP) was nothing, nada, zip. Like I was taking a placebo. I switched to methly b12 after 3 months, with no reaction. (rich's study showed that people had results after 3 months) I am still doing the SMP, (though I alternate between methyl b12 and hydroxo b12) just to finish off the supplements I bought. Check our Rich's study with Dr. Nathan to see how people reacted.
2 diaries by pwc's trying methylation on this page.
good luck,
JAH
Hi, JAH.
I'm sorry to hear that you have experienced no response from the methylation treatment.
Here are some possible reasons for non-response on the methylation protocol:
1. The person does not have a partial methylation cycle block. I think this one is unlikely if a person has the symptoms of ME/CFS, since nearly all who have these symptoms do have the partial block, based on testing of many people at this point. Nevertheless, I think this is a possibility. The methylation pathways panel from Health Diagnostics or the European Lab. of Nutrients will determine whether the partial block is present.
2. The person is lacking enough of the supporting vitamins and minerals for the enzymes in the methylation cycle and related pathways. Having HPU (hemopyrrollactamuria) is one possible cause of this. It depletes zinc, B6, biotin, and manganese. Testing is also available from the above labs for vitamins and minerals as well as for HPU.
3. The person has a high body burden of one or more of the toxic heavy elements that bind to sulfhydryl groups: mercury, lead, arsenic or cadmium. These elements can block enzymes in this part of the metabolism. Testing is available for these as well.
4. The person suffers from something that is holding down their glutathione. This might be mold illness or other biotoxin illnesses, Lyme disease and its coinfections, or viral infections. I think this one is more likely to hinder progress on the treatment, rather than to cause no response at all.
I hope this is helpful.
Best regards,
Rich