ramakentesh
Senior Member
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Something to look out for as it usually suggests an autoimmune basis (Autoimmune autonomic gangliopathy with autoantibodies against nicotinic a3 autonomic acetylcholine receptors.)
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Something to look out for as it usually suggests an autoimmune basis (Autoimmune autonomic gangliopathy with autoantibodies against nicotinic a3 autonomic acetylcholine receptors.)
For example, ME/CFS has autoantibodies that target the M1 subtype of muscarinic receptor, in 50% of patients. Orthostatic hypotension has autoantibodies that target both the M1 and M2 subtypes of muscarinic receptor (and in this case, the autoantibodies activate these two muscarinic receptors), as well as autoantibodies to ?1 and ?2 adrenergic receptors. Sjgren's syndrome has autoantibodies that target the M3 subtype of muscarinic receptor (and in this case, the autoantibodies block this M3 muscarinic receptor).
Can you refer me to the research that talks about muscarinic receptors? Other than perhaps mediating vasodilation I am confused about how muscaranic receptors would effect autonomic control as they are generally not ganglionic. i guess vasodilation?
As for why - gees if they knew that you'd be seeing some pretty impressive treatments for all autoimmune disease right across the board. Its alwasy the same situation - loss of self tolerance and then different arms of the immune system perpetually attacking specific targets - the targets being the main delineator of the disease.
Molecular mimicry is a popular possibility on patient discussion and some research theory - at least for Ankylosing Spondylitis. A bacteria enters the body that has the ability to trick a suspectible host into attacking antigens in the body that are similar to those attached to the bacteria. Much of the newer reseatch also points to a poor immune system going crazy because it cannot competantly rid the body of certain pathogens that contain proteins similar to the patient's histocompatibility.
Interesting, the Muscarinic acetylcholine receptor M1 is related to stomach acid secretion and low stomach acid is related to vitiligo which a subset of us also have. I remember Montoya bringing up vitiligo in one of his videos. Someday all of these clues will fit nicely together.