Hi, Gary.
Thanks for posting the additional information. It's very helpful.
I'll give you some comments on your Organix panel results below, but the bottom line from these results and the additional data you have provided is that I think you have an intestinal parasite that is causing major disruption to your digestive system and is severely limiting the absorption into your body of nutrients from your food. I don't know whether it is a protozoal parasite (a one-celled animal, like an amoeba) or a helminthic parasite (a worm), but I suspect that it is one or the other, or perhaps more than one. It think that this will have to be identified and corrected before you will be able to get your metabolism back to normal and regain your health.
I don't know how easily you can obtain stool testing from your location. I will suggest some that is available in the U.S. Since you have been able to do a Metametrix panel, I'm guessing that you could also run the Metametrix G.I. Function Profile. This is a stool test that uses DNA analysis to determine the microbes that are present in the stool, and it is capable of identifying parasites (protozoa and worms) as well as bacteria and yeasts. I would recommend getting this one. Perhaps you could get it the same way you got the Organix test. It can also be ordered from
www.directlabs.com without a doctor's order.
In addition, because I strongly suspect one or more parasites in your case, I would suggest doing the test offered by Dr. Omar Amin's parasitology lab in Arizona. Dr. Amin specializes in parasites, and his lab has a good reputation for identifying some that are unusual. His website is here:
http://www.parasitetesting.com/ You can order the test kit yourself from that site.
Now, with regard to your Organix test results, I think they are understandable in view of the additional information you have supplied. It appears to me that your metabolism has been surviving primarily by breaking down protein from your muscles and burning the resulting amino acids as fuel for the mitochondria. This would be consistent with the high value of alpha ketoglutarate and the somewhat higher values for the Krebs metabolites beyond it compared to those earlier in the Krebs cycle (citric acid and the two following it).
Much of the carbohydrate you have consumed has been converted to stored fat, and not much of it is currently being fed to the Krebs cycle. This would be consistent with pyruvic acid being below the detection limit, and citric acid as well.
You mentioned that you have malabsorption of fat. Of the fat that has been absorbed, it appears that not much of it is going into beta oxidation to be fed to the Krebs cycle in the mitochondria. This would be consistent with the low citric acid and the undetectable beta hydroxybutyric acid (indicating no ketosis). Instead, much of it is undergoing omega oxidation in the peroxisomes. This would be consistent with the elevated adipate and suberate.
On the second page of the Organix results, the two metabolites that are below the detection limit suggest that a couple of your branched-chain amino acids are severely depleted. If we had an amino acids analysis (urine or plasma), I think it would show that. This may indicate that you may not have very much muscle protein in reserve now. I think this would be consistent with your report that your muscle weight has converted to fat.
While your methylmalonate and formiminoglutamate are not elevated, it's important to note that these markers for methylation cycle partial block depend on having adequate levels of certain amino acids and vitamin B6. I think it is possible that you do have a methylation cycle partial block, even though these markers are not elevated in your case. Your relatively low pyroglutamate suggests that your glutathione is depleted. Your high sulfate would be consistent with disruption of your sulfur metabolism, including methylation and glutathione.
Your bacterial and yeast markers are low, and that's part of the reason why I suspect that you have a parasite rather than bacterial dysbiosis and/or yeast infection. However, you could still have these as well, and the testing I have suggested should find whatever is there.
I hope this is helpful, and I'm very sorry about the ordeal that you have been having to endure. Until you are able to fix the problems in the gut, you might benefit by taking a free-form amino acids supplement. This is like a predigested protein. Maybe some of these unbound amino acids would be absorbed, and it appears that your mitochondria are able to burn amino acids. It would be important to have enough B2 and B6 in your cells to do the conversions from one amino acid to another, so that they can be fed into the furnace (mitochondria). I'm suggesting this as a stopgap measure to help your metabolism until you can get your gut working better. I don't know how well it will work, but I think it is worth a try. The main thing needs to be to fix the gut.
Best regards,
Rich