I recently discovered this forum, and I'm so grateful for the depth of investigation happening here. I'm a clinician and I regularly screen for B12 deficiency using serum B12, urinary MMA and homocysteine (as well as a CBC). Not surprisingly, I frequently discover deficiencies. Until recently I've been using the protocol described in Could it Be B12, with only limited success. After reading these threads, I'm beginning to understand why.
I have a quick question: has anyone put together a bibliography of research studies that were reviewed to create the protocol described here? I'd love to read the original studies myself.
Thanks again for making this information available to clinicians and patients.
Hi, switters.
Welcome to Phoenix Rising!
Note that there are two protocols under discussion here. One is the Simplified Treatment Approach, which I have suggested. It is based on the full Yasko treatment program, and the theoretical underpinning for its use in ME/CFS is discussed in poster papers I have presented at the IACFS/ME.
You can find my documents in the General Wiki section of these forums. It is accessible at the bottom of the "Forum" page. There are references cited in the poster papers I presented in 2004, 2007 and 2009. You might also be interested in viewing the video or scanning the PDF slides from a seminar I presented in Sweden this past October 1. They can be found here:
http://iaomt.media.fnf.nu/2/skovde_2011_me_kroniskt_trotthetssyndrom/$%7Bweburl%7D
There are not many references cited there, but it is the most comprehensive description of the GD-MCB hypothesis at that time. Since then, I have made one change to the hypothesis to account for peroxynitrite reactions with 5-methyl tetrahydrofolate, as posted elsewhere on these forums. This is a work in progress, so I do not have a completely referenced manuscript that is current, but I think you will be able to find most of the references that support the hypothesis in papers in the General Wiki section.
The other protocol is the one proposed by Freddd on these forums. He has also participated in the WrongDiagnosis board, where one of the authors of the book you mentioned used to post, also. Freddd's protocol is applicable to a broad range of B12-related issues. I don't know if he has documented it with references. As I understand it, he developed it primarily out of his own experience and by the experiences of others.
There are some differences between these two protocols, and we are trying to learn more about how to determine which of these, or other methylation-type protocols would be best for a given individual. There are several other protocols in this category that are currently in use by various clinicians.
Best regards,
Rich