Sallysblooms
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You talked about uric acid in another thread. I wonder if you have any idea how this ties into kidney stones. I have them at ALLLLLL times. I have gone through so many procedures under anesthesia for the last 6 years or so. Lithotripsies and one procedure where they went up and lazered from the inside. THEN put in a HORRIBLE stent. Spend the day after in the emerg. room. I also NEVER pass them. They just grow...
I have urine that is not acidic. I am supposed to take Potassium Citrate and drink lots of lemon juice. It is genetic, but I am by far the worst in my family.
Just wonder what you think. I think the Potassium is dangerous since you are supposed to check the check the levels if you take it. Also, I wonder what it does to the blood pressure.
Just in case you have any ideas. Maybe others can help also.:Retro smile:
I have urine that is not acidic. I am supposed to take Potassium Citrate and drink lots of lemon juice. It is genetic, but I am by far the worst in my family.
Just wonder what you think. I think the Potassium is dangerous since you are supposed to check the check the levels if you take it. Also, I wonder what it does to the blood pressure.
Just in case you have any ideas. Maybe others can help also.:Retro smile:
Many ME and CFS patients have high levels of uric acid and not low levels. Uric acid is an antioxidant, but the parent purines are needed for nucleotide synthesis including ATP, RNA, and DNA. Many of the purines are conserved, and reconverted back to nucleotides.
Purines are essentially components of RNA and DNA and their breakdown products. I do not understand why they are considered amino acid breakdown products - this seems wrong. Indeed foods high in nucleotides and not proteins are what gout patients are told to avoid. They attempted to diagnose me with gout but it didn't hold up on close examination, and I did not respond to therapy (allopurinol).
Now muscle uses purines to keep the citric acid cycle going. They are heavily dependent on purines to maintain mitochondrial metabolites. So low purines or high purines might also be linked to muscle mitochondrial problems - I am not saying they are, I am saying they might be, its something that could be worth considering.
I wish I were more up to date on this but I am very out of date on the science of this, it was something I knew a lot about one to two decades ago but I have not been tracking recent developments.
Uric acid is a final breakdown product of purines, and is excreted. Along the way it also provides much needed antioxidant defence.
Note that a high turnover of purines will put a huge demand on folate and other vitamins. So the problem might be that methylfolate etc is overutilized in patients with high uric acid levels. Vitamin reserves might be low.
Please correct me if I am mistaken.
Bye
Alex