Dear Rydra,
I had to drop you a note to say that I too have the internal trembling and I have had it every since I began the protocol. It feels like a tuning fork in my body. Sometimes it is very pronounced and sometime not so much but it is almost always there. I have tried stopping and starting so many things and still it persists. I tired increasing my metafolin (I currently take 800 msg) to two of the 800 mcg and within three days, I got very dizzy and had to stop and go back to the 800 mcg. When we were posting on wrong diagnosis I raised this issue of internal tremors but no one seemed to have any answers. I wanted you to hear that I have the same thing too and mine has not been a result of stopping the protocol. It feels like I'm missing something or not getting enough of something or the balance is wrong. If we could figure this one out I would be dancing in the streets! The constant tremors are not only annoying they are worrisome.
Idie
Idie, I'm sorry you have this symptom. I do not always have it so I think I will eventually be able to find out what causes it. It is very hard for me though because I have so many genetic defects that 1 change can throw me into a completely different state (such as from high blood pressure to low blood pressure), each with it's own emergencies to figure out. It is not so simple as stopping/starting one thing, getting one symptom. If I stop one thing I may sudeenly need 3 other things or die (and restarting the thing I stopped wont fix it until I get those 3 other things). It's a state machine and when something throws me into a different state, the way back is not always the same thing.
Maybe I'll do some research. I am just so swamped right now that just now I havent the time.
Regards
Rydra
P.S. 'Determined' triggered a memory on another topic that might pertain:
Here is what I wrote there:
Determined, I have noticed such things in the past - in my case with inflammation - In fact - I'll have to tell this to Idie - internal trembling would go away as well as any joint pain if I were fighting off a cold - leading me to believe these were caused by inflammatory cytokines which in the event of an actual infection went off to fight THAT instead of me. So...I would guess that chemicals cause inflammatory cytokines for you and I'll bet strategies against those might do the trick. But what are such strategies? Well one is high dose omega-3 (like 7-9g/day) as these use up the enzymes required to produce inflammatory cytokines. When I had a horrible new allergy develop last winter I found 20 Spirulina pills woul do the same thing. Neither is fun as it's so much. There are herbs that are supposed to help with inflammation, thus must target those cytokines, like curcumin. However if you are on meds, and you are, these strategies can be dangerous. Omega-3 thins the blood. I don't know what spirulina does but you can bet there are a lot of constituents in at, any one of which might interact with your meds. Curcumin interacts with 50% of the medicines on the market via CYP3A4...it will PREVENT you from eliminating any medication which is supposed to be cleared via CYP3A4 (50% of the drugs on the market) and this will cause their levels to rise to where they could be toxic. So many herbs do just this sort of thing that I would never take any herbs if I were on drugs. As to blood if your drugs thin your blood or affect clotting this is also something you need to do only under a doctor;s care. For someone NOT on drugs, the above are things I might look into.
(P.S. I am not saying that I have ever tested any of the above things for getting rid of internal trembling...but those things do get rid of sinusitis crabbed up head and/or joint pain, so maybe would also work for internal trembling. I do not feel entirely peaceful but since the day of my post above I have not have internal trembling. I want to say that I also added CLA to my protocol that day as I read we dont get it in our milk etc anymore, I also took 1g omega 3 to go with it and I drank a lot of milk. Those were the new things I did that day and since. But I cannot rule out that 3 days before that I restarted my olive leaf extract and maybe that did it over time. It is really hard to say.
Rydra
Ok, here's a study about CLA:
Conjugated linoleic acid reduces body fats and cytokine levels of mice. (PMID:12036077)
Akahoshi A, Goto Y, Murao K, Miyazaki T, Yamasaki M, Nonaka M, Yamada K, Sugano M
In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-alpha and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.
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I started aking it 2x/day (Jarrow) because I think Life Extension said it causes production of ANTI inflammatory cytokines. Inflammatory cytokines dysregulate the methyl cycle I believe (dont know exactly which enzymes are affcted by which cytokines and I dont beieve science knows that yet anyway).
So I am now thinking that it might be the CLA helping me out. CLA, fyi, does not help you lose weight - it just redistributes your weight to muscle instead of fat. You are supposed to take much more to do that - like maybe 5 pills a day. But I am not very good at anything that requires more than twice a day.
Ok, I checked LEF - they say 4g/day. It turns out LEF was not my source - my actual source says 3-6g/day. Both sources say it lowers cholesterol and stops insulin resistance. Oh, I di dnot find that it increases any anti-inflammatory cytokine, I found it is a COX-2 inhibitor (like curcumin and many other things...meaning like any other COX-2 inhibitor it can make your stomach bleed). Now I am going to refresh my memory because there was something that increased anti-inflammatory cytokined (PGE1)? Maybe GLA? Yes, GLA is needed to produceGE1 which creates anti-inflammatory cytokines. My book says deficiencies of biotin, B3, B6, magnesium, or zinc can prevent you from making PGE1. Well I have tried that evening primrose oil and it never did anything for me. Of course evrything could be in a synergy and I am certainly taking different supplements now that in the past.
Anyway, not sure if CLA helps internal trembling. It may be that any COX-2 inhibitor does and I have an array that I sometimes take - which couldbe why I sometimes have this problem and sometimes not?
OOPS! I am editting this the next day to say: FORGET IT. I DISCOVERED I AM CATCHING A COLD so that is why my internal trembling stopped...there is something else for the inflammatory cytokines to attack. However I still think this is a clue. I think - odd as it may seem - that internal trembling is caused by inflammatory cytokines. So things that stop them (there are many) would be likely to help it. Pay attention to if your trembling goes away when you have a sore throat or are fighting infection. In the meantime, you could try 9g omega-3 as this will prevent inflammatory cytokines (this is just a test - nyou can find a way you like to do this better later). Now O-3 works by suppressing formation if inflammatory cytokines (because it uses up the enzymes needed to make them) so it WILL NOT TAKE DOWN CURRENT INFLAMMATION from pre-existing cytokines. So it may take up to 3 days to work. If you can verify it is caused by cytokines, you can try various herbs which suppress various cytokines to see if there is a less-pill way to take care of it. I am not sure - it is only a thought. DHEA reduced/eliminates TNF-alpha which may be why it helps prevent dysregultion of the methyl cycle. Curcumin suppresses some cytokines or other, so does milk thistle. Many, many herbs do this. It is extremely likely that a given herb will interact with a given medication if you are on any...suppressing clearance of the drug until it builds up to toxic levels. So please do not think I am suggesting herbs - you are on your own trying that. It's just an idea that might be useful.
