Hi,
Looking at both pools it seems like more people reported major improvements using fredd supplements. I know the size of the sample is too small to draw conclusion but I have a bias toward choosing fredd one because I can find the supplement easily on iherb and I think it's cheaper too.
If you think I'm better one with one or another for helping my CFS symptoms, please share.
I'm thinking it could help for some recent symptoms I started having, I started sweating and urinating a lot since june to the point that my body feels totally out of balance, muscles doesn't work at all. I'm guessing vasopressin production is defective and I read that gluthatione depletion could cause that. Strangely, I felt like I was improving before that, maybe detox deplete my gluthatione store, can't say...
Thx guys!
Hi, gu3vara.
I hope you will be able to choose a protocol that will help you, whichever one it is.
My current thinking about the choice between hydroxocobalamin and methylcobalamin for treating ME/CFS is still to favor hydroxocobalamin to start with, unless a person has very low glutathione or very low SAMe, or both, on the Health Diagnostics methylation pathways panel. In those cases, I think the cells will have difficulty making their own methylcobalamin. I note that Dr. Amy Yasko uses a different criterion. She bases this choice on a person's genomic polymorphisms on her nutrigenomic panel, specifically the COMT and VDR polymorphisms. Her thinking is that having the COMT polymorphisms and not having the VDR polymorphism causes a person to have a lower need for methyl groups, and thus hydroxocobalamin would be the choice, and vice versa. So I would say that there is not total agreement on this.
I also suggest that if a person has tried hydroxocobalamin for 3 months, as part of the simplified protocol, and has not experienced net benefit, it is time to consider some testing to see what is going on, or a change in protocol, if testing is not feasible.
With regard to dosages, I still favor something like 2 milligrams per day sublingual as the nominal B12 dosage (some may need more), and a few hundred micrograms of the active folates.
Going much higher with these two seems to cause overdriving of the methylation cycle, which appears to hinder the recovery of glutathione.
All this having been said, I also acknowledge that there are people who have inborn errors of metabolism in their intracellular B12 processing enzymes (which I think is the case for Freddd himself), and in these cases, going to higher dosages with the coenzyme forms of B12 is likely necessary. It requires specialized testing, done at the University of Toronto, to determine whether these inborn errors are present.
There may also be people whose blood-brain barrier is not able to transport B12 or folate at normal rates, and these people may need to go to higher dosages, also. Freddd seems to have this issue as well. Lately there has been the discovery in autism that some people develop autoantibodies to the folate receptor in the blood-brain barrier, and this hinders the entry of folate into the brain. This apparently occurs because there are soluble folate receptors in milk, and if they are able to leak from the gut into the blood due to a leaky gut situation, as is common in autism and ME/CFS, then the immune system develops antibodies against them, and these attack the person's own folate receptors. I think the original work on this was done by E.V. Quadros et al, and work in autism has been done by Dr. Dan Rossignol.
Again, I hope you will be able to choose a protocol that will work for you.
Best regards,
Rich