Life Extension through Oligomer Treatment of Telomeres

[Waverunner]

Would be interesting to know how good it really works.

Author: Will Vladimir Stoyanov

Abstract: Telomere shortening is thought to play significant role in cellular aging contributing to human aging and longevity. Critical telomere shortening affects different genes, as human genomes vary, which is why the cascades differ, hence the different effects, organ failures and cancers. For years telomere length maintenance has been targeted. Currently telomerase activators and oligomers addition treatments are available to purchase. Variations of telomere shortening occur within same type of tissue, as well as different tissue types, from same and different individuals. Each old tissue is a mix of mainly old cells with short telomeres less than 5KB and some new cells with normal telomeres more than 15KB. To increase ~20% thus significantly the life span of these human skin cells mix, there were many telomere shortening factors considered, including RNA primers and the t-loop deletion factor. Ideal treatment appears to be ~5KB 5'-(TTAGGG)n-3' oligos dose spread over 1 year, or if administered at once it needs additional dose of 5'CCCTAA3', so that they bind inside the nuclei to reach the ~5KB extension at once. All oligos (TTAGGG)1-50 work, so dosage, frequency and cost considerations suggest as much cheaper to use shorter oligos, e.g. where n=15, 10 or even 5. Treatment per year per organ cost much less compare to telomerase activators. Treatment is harmless, so in 10 years treatment can be repeated for another ~20% and if done again another ~20%. Tests have not been testing to increase human skin cells life span for more than 52%, but theoretically it should work for as long as used.

[video=youtube;1Vw5QAmZsiE]http://www.youtube.com/watch?feature=player_embedded&v=1Vw5QAmZsiE[/video]

Here's the full abstract:

http://sites.google.com/site/journal1stoyanov/oligos-maintaining-telomere-length

 

[Snow Leopard]

The problem is that the telomere shortening is like a built in killswitch. Telomere length maintenance is has already been shown to be associated with cancer.
I'd be extremely skeptical of this extending life until I had seen replicated in vivo testing (eg rat testing at the least).

 

[Waverunner]

The problem is that the telomere shortening is like a built in killswitch. Telomere length maintenance is has already been shown to be associated with cancer.
I'd be extremely skeptical of this extending life until I had seen replicated in vivo testing (eg rat testing at the least).

Yes and no. The problem all humans encounter is that cells cannot divide forever. So no matter what we eat or how healthy we live, we will sooner or later die because our cells age. The theoretical maximum life span of a human is 125 years. Everytime a cell divides, the telomeres on chromosomes shorten. This is very bad because after the Hayflick Limit is reached, the telomeres are so short that they don't protect the chromosomes enough anymore. The cell will die.

There are some cells however which can divide forever. They are immortal. This is awesome because many scientists in the life extension field say that if our telomeres wouldn't shorten, we could live hundreds of years. There is one big twist of course. Cancer! Cancer cells are immortal. The only reason why cancer cells can divide forever is that they find ways to protect their telomeres from shortening when they divide. They do this through an enzyme called telomerase. Recently scientists even found out that there are alternative ways of cancer cells to protect their telomeres while not using telomerase.

One last thing. It is important to know that shortened telomeres seem to increase the risk for cancer as well. The blocking of telomerase could disable cancer cells because they become mortal now. So telomeres can be key to death and life extension at the same time.

 

[Sallysblooms]

I take Resveretrol to help with the telomeres as well as other things. Good for a lot of reasons.